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Results: 1 to 20 of 99

1.

Rapid measurement of intracellular unbound drug concentrations.

Mateus A, Matsson P, Artursson P.

Mol Pharm. 2013 Jun 3;10(6):2467-78. doi: 10.1021/mp4000822. Epub 2013 May 15.

PMID:
23631740
[PubMed - indexed for MEDLINE]
Free Article
2.

Determination of intracellular unbound concentrations and subcellular localization of drugs in rat sandwich-cultured hepatocytes compared with liver tissue.

Pfeifer ND, Harris KB, Yan GZ, Brouwer KL.

Drug Metab Dispos. 2013 Nov;41(11):1949-56. doi: 10.1124/dmd.113.052134. Epub 2013 Aug 29.

PMID:
23990525
[PubMed - indexed for MEDLINE]
3.

Simultaneous assessment of uptake and metabolism in rat hepatocytes: a comprehensive mechanistic model.

Ménochet K, Kenworthy KE, Houston JB, Galetin A.

J Pharmacol Exp Ther. 2012 Apr;341(1):2-15. doi: 10.1124/jpet.111.187112. Epub 2011 Dec 21.

PMID:
22190645
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Intracellular drug concentrations and transporters: measurement, modeling, and implications for the liver.

Chu X, Korzekwa K, Elsby R, Fenner K, Galetin A, Lai Y, Matsson P, Moss A, Nagar S, Rosania GR, Bai JP, Polli JW, Sugiyama Y, Brouwer KL; International Transporter Consortium.

Clin Pharmacol Ther. 2013 Jul;94(1):126-41. doi: 10.1038/clpt.2013.78. Epub 2013 Apr 10. Review.

PMID:
23588320
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Hepatocellular binding of drugs: correction for unbound fraction in hepatocyte incubations using microsomal binding or drug lipophilicity data.

Kilford PJ, Gertz M, Houston JB, Galetin A.

Drug Metab Dispos. 2008 Jul;36(7):1194-7. doi: 10.1124/dmd.108.020834. Epub 2008 Apr 14.

PMID:
18411401
[PubMed - indexed for MEDLINE]
Free Article
7.

In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids.

Fridén M, Gupta A, Antonsson M, Bredberg U, Hammarlund-Udenaes M.

Drug Metab Dispos. 2007 Sep;35(9):1711-9. Epub 2007 Jun 25.

PMID:
17591680
[PubMed - indexed for MEDLINE]
Free Article
8.

Direct determination of the ratio of unbound fraction in plasma to unbound fraction in microsomal system (fu p/fu mic) for refined prediction of phase I mediated metabolic hepatic clearance.

Deshmukh SV, Harsch A.

J Pharmacol Toxicol Methods. 2011 Jan-Feb;63(1):35-9. doi: 10.1016/j.vascn.2010.04.003. Epub 2010 Apr 28.

PMID:
20433934
[PubMed - indexed for MEDLINE]
9.

Human hepatocytes in primary culture: the choice to investigate drug metabolism in man.

Gómez-Lechón MJ, Donato MT, Castell JV, Jover R.

Curr Drug Metab. 2004 Oct;5(5):443-62. Review.

PMID:
15544436
[PubMed - indexed for MEDLINE]
10.

Measurement and analysis of unbound drug concentrations.

Wright JD, Boudinot FD, Ujhelyi MR.

Clin Pharmacokinet. 1996 Jun;30(6):445-62. Review.

PMID:
8792057
[PubMed - indexed for MEDLINE]
11.

Protein binding in antiretroviral therapies.

Boffito M, Back DJ, Blaschke TF, Rowland M, Bertz RJ, Gerber JG, Miller V.

AIDS Res Hum Retroviruses. 2003 Sep;19(9):825-35. Review.

PMID:
14585213
[PubMed - indexed for MEDLINE]
12.

Insight into tissue unbound concentration: utility in drug discovery and development.

Mariappan TT, Mandlekar S, Marathe P.

Curr Drug Metab. 2013 Mar;14(3):324-40. Review.

PMID:
23167621
[PubMed - indexed for MEDLINE]
13.

Do we need to optimize plasma protein and tissue binding in drug discovery?

Liu X, Chen C, Hop CE.

Curr Top Med Chem. 2011;11(4):450-66. Review.

PMID:
21320069
[PubMed - indexed for MEDLINE]
14.

Models to predict unbound intracellular drug concentrations in the presence of transporters.

Korzekwa KR, Nagar S, Tucker J, Weiskircher EA, Bhoopathy S, Hidalgo IJ.

Drug Metab Dispos. 2012 May;40(5):865-76. doi: 10.1124/dmd.111.044289. Epub 2012 Jan 25.

PMID:
22279052
[PubMed - indexed for MEDLINE]
Free Article
15.

Evaluation of hepatic clearance prediction using in vitro data: emphasis on fraction unbound in plasma and drug ionisation using a database of 107 drugs.

Hallifax D, Houston JB.

J Pharm Sci. 2012 Aug;101(8):2645-52. doi: 10.1002/jps.23202. Epub 2012 Jun 14.

PMID:
22700322
[PubMed - indexed for MEDLINE]
16.

Uptake and intracellular binding of lipophilic amine drugs by isolated rat hepatocytes and implications for prediction of in vivo metabolic clearance.

Hallifax D, Houston JB.

Drug Metab Dispos. 2006 Nov;34(11):1829-36. Epub 2006 Aug 1.

PMID:
16882765
[PubMed - indexed for MEDLINE]
Free Article
17.

Use of unbound volumes of drug distribution in pharmacokinetic calculations.

Stepensky D.

Eur J Pharm Sci. 2011 Jan 18;42(1-2):91-8. doi: 10.1016/j.ejps.2010.10.011. Epub 2010 Nov 2.

PMID:
21050885
[PubMed - indexed for MEDLINE]
18.

A high-throughput cell-based method to predict the unbound drug fraction in the brain.

Mateus A, Matsson P, Artursson P.

J Med Chem. 2014 Apr 10;57(7):3005-10. doi: 10.1021/jm401963n. Epub 2014 Mar 20.

PMID:
24601604
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Effect of culture time on the basal expression levels of drug transporters in sandwich-cultured primary rat hepatocytes.

Tchaparian EH, Houghton JS, Uyeda C, Grillo MP, Jin L.

Drug Metab Dispos. 2011 Dec;39(12):2387-94. doi: 10.1124/dmd.111.039545. Epub 2011 Aug 24.

PMID:
21865320
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Importance of protein binding for the interpretation of serum or plasma drug concentrations.

Greenblatt DJ, Sellers EM, Koch-Weser J.

J Clin Pharmacol. 1982 May-Jun;22(5-6):259-63.

PMID:
7107972
[PubMed - indexed for MEDLINE]

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