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Results: 1 to 20 of 90

1.

[Effects of Rheb overexpression in HL-60 and K562 leukemia cell lines].

Xu QZ, Wang XM, Wang FF, Gao YN, Zhang YC, Ju ZY, Cheng T, Yuan WP, Liu HZ.

Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013 Apr;21(2):268-72. doi: 10.7534/j.issn.1009-2137.2013.02.002. Chinese.

PMID:
23628014
[PubMed - indexed for MEDLINE]
2.

Regulation of androgen receptor transactivity and mTOR-S6 kinase pathway by Rheb in prostate cancer cell proliferation.

Kobayashi T, Shimizu Y, Terada N, Yamasaki T, Nakamura E, Toda Y, Nishiyama H, Kamoto T, Ogawa O, Inoue T.

Prostate. 2010 Jun 1;70(8):866-74. doi: 10.1002/pros.21120.

PMID:
20127734
[PubMed - indexed for MEDLINE]
3.

Ras homolog enriched in brain (Rheb) enhances apoptotic signaling.

Karassek S, Berghaus C, Schwarten M, Goemans CG, Ohse N, Kock G, Jockers K, Neumann S, Gottfried S, Herrmann C, Heumann R, Stoll R.

J Biol Chem. 2010 Oct 29;285(44):33979-91. doi: 10.1074/jbc.M109.095968. Epub 2010 Aug 4.

PMID:
20685651
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.

Tee AR, Manning BD, Roux PP, Cantley LC, Blenis J.

Curr Biol. 2003 Aug 5;13(15):1259-68.

PMID:
12906785
[PubMed - indexed for MEDLINE]
Free Article
5.

Phospholipase D1 is an effector of Rheb in the mTOR pathway.

Sun Y, Fang Y, Yoon MS, Zhang C, Roccio M, Zwartkruis FJ, Armstrong M, Brown HA, Chen J.

Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8286-91. doi: 10.1073/pnas.0712268105. Epub 2008 Jun 11.

PMID:
18550814
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Farnesyltransferase inhibitor tipifarnib inhibits Rheb prenylation and stabilizes Bax in acute myelogenous leukemia cells.

Ding H, McDonald JS, Yun S, Schneider PA, Peterson KL, Flatten KS, Loegering DA, Oberg AL, Riska SM, Huang S, Sinicrope FA, Adjei AA, Karp JE, Meng XW, Kaufmann SH.

Haematologica. 2014 Jan;99(1):60-9. doi: 10.3324/haematol.2013.087734. Epub 2013 Aug 30.

PMID:
23996484
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis.

Lu ZH, Shvartsman MB, Lee AY, Shao JM, Murray MM, Kladney RD, Fan D, Krajewski S, Chiang GG, Mills GB, Arbeit JM.

Cancer Res. 2010 Apr 15;70(8):3287-98. doi: 10.1158/0008-5472.CAN-09-3467. Epub 2010 Apr 13.

PMID:
20388784
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

The farnesyl transferase inhibitor (FTI) SCH66336 (lonafarnib) inhibits Rheb farnesylation and mTOR signaling. Role in FTI enhancement of taxane and tamoxifen anti-tumor activity.

Basso AD, Mirza A, Liu G, Long BJ, Bishop WR, Kirschmeier P.

J Biol Chem. 2005 Sep 2;280(35):31101-8. Epub 2005 Jul 8.

PMID:
16006564
[PubMed - indexed for MEDLINE]
Free Article
9.

The Rheb family of GTP-binding proteins.

Aspuria PJ, Tamanoi F.

Cell Signal. 2004 Oct;16(10):1105-12. Review.

PMID:
15240005
[PubMed - indexed for MEDLINE]
10.

Rheb, an activator of target of rapamycin, in the blackback land crab, Gecarcinus lateralis: cloning and effects of molting and unweighting on expression in skeletal muscle.

MacLea KS, Abuhagr AM, Pitts NL, Covi JA, Bader BD, Chang ES, Mykles DL.

J Exp Biol. 2012 Feb 15;215(Pt 4):590-604. doi: 10.1242/jeb.062869.

PMID:
22279066
[PubMed - indexed for MEDLINE]
Free Article
11.

Rheb promotes cell growth as a component of the insulin/TOR signalling network.

Saucedo LJ, Gao X, Chiarelli DA, Li L, Pan D, Edgar BA.

Nat Cell Biol. 2003 Jun;5(6):566-71. Erratum in: Nat Cell Biol. 2003 Jul;5(7):680.

PMID:
12766776
[PubMed - indexed for MEDLINE]
12.

Raptor and Rheb negatively regulate skeletal myogenesis through suppression of insulin receptor substrate 1 (IRS1).

Ge Y, Yoon MS, Chen J.

J Biol Chem. 2011 Oct 14;286(41):35675-82. doi: 10.1074/jbc.M111.262881. Epub 2011 Aug 18.

PMID:
21852229
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Rheb activates protein synthesis and growth in adult rat ventricular cardiomyocytes.

Wang Y, Huang BP, Luciani DS, Wang X, Johnson JD, Proud CG.

J Mol Cell Cardiol. 2008 Dec;45(6):812-20. doi: 10.1016/j.yjmcc.2008.07.016. Epub 2008 Aug 3.

PMID:
18722381
[PubMed - indexed for MEDLINE]
14.

Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.

Tee AR, Blenis J, Proud CG.

FEBS Lett. 2005 Aug 29;579(21):4763-8.

PMID:
16098514
[PubMed - indexed for MEDLINE]
Free Article
15.

Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling.

Wang X, Fonseca BD, Tang H, Liu R, Elia A, Clemens MJ, Bommer UA, Proud CG.

J Biol Chem. 2008 Nov 7;283(45):30482-92. doi: 10.1074/jbc.M803348200. Epub 2008 Aug 1.

PMID:
18676370
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR)-independent.

Karbowniczek M, Cash T, Cheung M, Robertson GP, Astrinidis A, Henske EP.

J Biol Chem. 2004 Jul 16;279(29):29930-7. Epub 2004 May 18.

PMID:
15150271
[PubMed - indexed for MEDLINE]
Free Article
17.

Neurofibromatosis-1 regulates mTOR-mediated astrocyte growth and glioma formation in a TSC/Rheb-independent manner.

Banerjee S, Crouse NR, Emnett RJ, Gianino SM, Gutmann DH.

Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):15996-6001. doi: 10.1073/pnas.1019012108. Epub 2011 Sep 6.

PMID:
21896734
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Rheb binds and regulates the mTOR kinase.

Long X, Lin Y, Ortiz-Vega S, Yonezawa K, Avruch J.

Curr Biol. 2005 Apr 26;15(8):702-13.

PMID:
15854902
[PubMed - indexed for MEDLINE]
Free Article
19.

Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency.

Long X, Ortiz-Vega S, Lin Y, Avruch J.

J Biol Chem. 2005 Jun 24;280(25):23433-6. Epub 2005 May 5.

PMID:
15878852
[PubMed - indexed for MEDLINE]
Free Article
20.

Glycolytic flux signals to mTOR through glyceraldehyde-3-phosphate dehydrogenase-mediated regulation of Rheb.

Lee MN, Ha SH, Kim J, Koh A, Lee CS, Kim JH, Jeon H, Kim DH, Suh PG, Ryu SH.

Mol Cell Biol. 2009 Jul;29(14):3991-4001. doi: 10.1128/MCB.00165-09. Epub 2009 May 18.

PMID:
19451232
[PubMed - indexed for MEDLINE]
Free PMC Article

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