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Resveratrol reduces acute lung injury in a LPS‑induced sepsis mouse model via activation of Sirt1.

Li T, Zhang J, Feng J, Li Q, Wu L, Ye Q, Sun J, Lin Y, Zhang M, Huang R, Cheng J, Cao Y, Xiang G, Zhang J, Wu Q.

Mol Med Rep. 2013 Jun;7(6):1889-95. doi: 10.3892/mmr.2013.1444. Epub 2013 Apr 26.


Activation of Sirt1 by resveratrol inhibits TNF-α induced inflammation in fibroblasts.

Zhu X, Liu Q, Wang M, Liang M, Yang X, Xu X, Zou H, Qiu J.

PLoS One. 2011;6(11):e27081. doi: 10.1371/journal.pone.0027081. Epub 2011 Nov 1.


Novel role of resveratrol: suppression of high-mobility group protein box 1 nucleocytoplasmic translocation by the upregulation of sirtuin 1 in sepsis-induced liver injury.

Xu W, Lu Y, Yao J, Li Z, Chen Z, Wang G, Jing H, Zhang X, Li M, Peng J, Tian X.

Shock. 2014 Nov;42(5):440-7. doi: 10.1097/SHK.0000000000000225.


Protective effect of resveratrol on acute lung injury induced by lipopolysaccharide in mice.

Cao Q, Jing C, Tang X, Yin Y, Han X, Wu W.

Anat Rec (Hoboken). 2011 Mar;294(3):527-32. doi: 10.1002/ar.21331. Epub 2011 Jan 31.


Resveratrol inhibits ionising irradiation-induced inflammation in MSCs by activating SIRT1 and limiting NLRP-3 inflammasome activation.

Fu Y, Wang Y, Du L, Xu C, Cao J, Fan T, Liu J, Su X, Fan S, Liu Q, Fan F.

Int J Mol Sci. 2013 Jul 8;14(7):14105-18. doi: 10.3390/ijms140714105.


Protective effect of resveratrol against acute lung injury induced by lipopolysaccharide via inhibiting the myd88-dependent Toll-like receptor 4 signaling pathway.

Zhang Z, Chen N, Liu JB, Wu JB, Zhang J, Zhang Y, Jiang X.

Mol Med Rep. 2014 Jul;10(1):101-6. doi: 10.3892/mmr.2014.2226. Epub 2014 May 9.


Resveratrol inhibits LPS-induced MAPKs activation via activation of the phosphatidylinositol 3-kinase pathway in murine RAW 264.7 macrophage cells.

Zong Y, Sun L, Liu B, Deng YS, Zhan D, Chen YL, He Y, Liu J, Zhang ZJ, Sun J, Lu D.

PLoS One. 2012;7(8):e44107. doi: 10.1371/journal.pone.0044107. Epub 2012 Aug 31.


Resveratrol inhibits interleukin 1β-mediated inducible nitric oxide synthase expression in articular chondrocytes by activating SIRT1 and thereby suppressing nuclear factor-κB activity.

Lei M, Wang JG, Xiao DM, Fan M, Wang DP, Xiong JY, Chen Y, Ding Y, Liu SL.

Eur J Pharmacol. 2012 Jan 15;674(2-3):73-9. doi: 10.1016/j.ejphar.2011.10.015. Epub 2011 Oct 25.


Isoflurane preconditioning ameliorates endotoxin-induced acute lung injury and mortality in rats.

Li QF, Zhu YS, Jiang H, Xu H, Sun Y.

Anesth Analg. 2009 Nov;109(5):1591-7. doi: 10.1213/ANE.0b013e3181baf506.


Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma.

Ichikawa T, Hayashi R, Suzuki K, Imanishi S, Kambara K, Okazawa S, Inomata M, Yamada T, Yamazaki Y, Koshimizu Y, Miwa T, Matsui S, Usui I, Urakaze M, Matsuya Y, Sasahara M, Tobe K.

Respirology. 2013 Feb;18(2):332-9. doi: 10.1111/j.1440-1843.2012.02284.x.


Fructose-1,6-diphosphate attenuates acute lung injury induced by lipopolysaccharide in mice.

Yin H, Jin XB, Gong Q, Yang H, Hu LY, Gong FL, Zhu JY.

Int Immunopharmacol. 2008 Dec 20;8(13-14):1842-7. doi: 10.1016/j.intimp.2008.09.004. Epub 2008 Sep 29.


SIRT1 protects rat lung tissue against severe burn-induced remote ALI by attenuating the apoptosis of PMVECs via p38 MAPK signaling.

Bai X, Fan L, He T, Jia W, Yang L, Zhang J, Liu Y, Shi J, Su L, Hu D.

Sci Rep. 2015 May 20;5:10277. doi: 10.1038/srep10277.


The red wine polyphenol resveratrol shows promising potential for the treatment of nucleus pulposus-mediated pain in vitro and in vivo.

Wuertz K, Quero L, Sekiguchi M, Klawitter M, Nerlich A, Konno S, Kikuchi S, Boos N.

Spine (Phila Pa 1976). 2011 Oct 1;36(21):E1373-84. doi: 10.1097/BRS.0b013e318221e655.


Resveratrol inhibits inflammatory responses via the mammalian target of rapamycin signaling pathway in cultured LPS-stimulated microglial cells.

Zhong LM, Zong Y, Sun L, Guo JZ, Zhang W, He Y, Song R, Wang WM, Xiao CJ, Lu D.

PLoS One. 2012;7(2):e32195. doi: 10.1371/journal.pone.0032195. Epub 2012 Feb 21.


Silencing Angiopoietin-Like Protein 4 (ANGPTL4) Protects Against Lipopolysaccharide-Induced Acute Lung Injury Via Regulating SIRT1 /NF-kB Pathway.

Guo L, Li S, Zhao Y, Qian P, Ji F, Qian L, Wu X, Qian G.

J Cell Physiol. 2015 Oct;230(10):2390-402. doi: 10.1002/jcp.24969.


Anti-inflammatory effects of triptolide by inhibiting the NF-κB signalling pathway in LPS-induced acute lung injury in a murine model.

Wang X, Zhang L, Duan W, Liu B, Gong P, Ding Y, Wu X.

Mol Med Rep. 2014 Jul;10(1):447-52. doi: 10.3892/mmr.2014.2191. Epub 2014 Apr 28.


Tubeimoside-1 attenuates LPS-induced inflammation in RAW 264.7 macrophages and mouse models.

Wu Q, Sun G, Yuan X, Soromou LW, Chen N, Xiong Y, Feng H.

Immunopharmacol Immunotoxicol. 2013 Aug;35(4):514-23. doi: 10.3109/08923973.2013.810643. Epub 2013 Jul 11.


Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway.

Ye J, Liu Z, Wei J, Lu L, Huang Y, Luo L, Xie H.

Neurosci Lett. 2013 Oct 11;553:72-7. doi: 10.1016/j.neulet.2013.08.020. Epub 2013 Aug 21.


Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK-SIRT1-PGC1α axis in db/db mice.

Kim MY, Lim JH, Youn HH, Hong YA, Yang KS, Park HS, Chung S, Ko SH, Shin SJ, Choi BS, Kim HW, Kim YS, Lee JH, Chang YS, Park CW.

Diabetologia. 2013 Jan;56(1):204-17. doi: 10.1007/s00125-012-2747-2. Epub 2012 Oct 23. Erratum in: Diabetologia. 2013 Mar;56(3):681. Koh, S H [corrected to Ko, S H].


Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations.

Csiszar A, Labinskyy N, Podlutsky A, Kaminski PM, Wolin MS, Zhang C, Mukhopadhyay P, Pacher P, Hu F, de Cabo R, Ballabh P, Ungvari Z.

Am J Physiol Heart Circ Physiol. 2008 Jun;294(6):H2721-35. doi: 10.1152/ajpheart.00235.2008. Epub 2008 Apr 18.

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