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Results: 1 to 20 of 108

1.

Development of cell-active non-peptidyl inhibitors of cysteine cathepsins.

Dana D, Davalos AR, De S, Rathod P, Gamage RK, Huestis J, Afzal N, Zavlanov Y, Paroly SS, Rotenberg SA, Subramaniam G, Mark KJ, Chang EJ, Kumar S.

Bioorg Med Chem. 2013 Jun 1;21(11):2975-87. doi: 10.1016/j.bmc.2013.03.062. Epub 2013 Apr 2.

PMID:
23623677
[PubMed - indexed for MEDLINE]
2.

Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L.

Falgueyret JP, Oballa RM, Okamoto O, Wesolowski G, Aubin Y, Rydzewski RM, Prasit P, Riendeau D, Rodan SB, Percival MD.

J Med Chem. 2001 Jan 4;44(1):94-104.

PMID:
11141092
[PubMed - indexed for MEDLINE]
3.

Azepanone-based inhibitors of human cathepsin L.

Marquis RW, James I, Zeng J, Trout RE, Thompson S, Rahman A, Yamashita DS, Xie R, Ru Y, Gress CJ, Blake S, Lark MA, Hwang SM, Tomaszek T, Offen P, Head MS, Cummings MD, Veber DF.

J Med Chem. 2005 Nov 3;48(22):6870-8.

PMID:
16250645
[PubMed - indexed for MEDLINE]
4.

Peptidyl allyl sulfones: a new class of inhibitors for clan CA cysteine proteases.

Götz MG, Caffrey CR, Hansell E, McKerrow JH, Powers JC.

Bioorg Med Chem. 2004 Oct 1;12(19):5203-11.

PMID:
15351403
[PubMed - indexed for MEDLINE]
5.

Development of peptidomimetics with a vinyl sulfone warhead as irreversible falcipain-2 inhibitors.

Ettari R, Nizi E, Di Francesco ME, Dude MA, Pradel G, Vicík R, Schirmeister T, Micale N, Grasso S, Zappalà M.

J Med Chem. 2008 Feb 28;51(4):988-96. doi: 10.1021/jm701141u. Epub 2008 Jan 31.

PMID:
18232656
[PubMed - indexed for MEDLINE]
6.

6-Acylamino-penam derivatives: synthesis and inhibition of cathepsins B, L, K, and S.

Zhou NE, Kaleta J, Purisima E, Menard R, Micetich RG, Singh R.

Bioorg Med Chem Lett. 2002 Dec 2;12(23):3417-9.

PMID:
12419374
[PubMed - indexed for MEDLINE]
7.

Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L.

Brömme D, Klaus JL, Okamoto K, Rasnick D, Palmer JT.

Biochem J. 1996 Apr 1;315 ( Pt 1):85-9.

PMID:
8670136
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Crystal structure of human cathepsin V.

Somoza JR, Zhan H, Bowman KK, Yu L, Mortara KD, Palmer JT, Clark JM, McGrath ME.

Biochemistry. 2000 Oct 17;39(41):12543-51. Erratum in: Biochemistry 2001 Apr 3;40(13):4200.

PMID:
11027133
[PubMed - indexed for MEDLINE]
9.

3,4-disubstituted azetidinones as selective inhibitors of the cysteine protease cathepsin K. Exploring P3 elements for potency and selectivity.

Setti EL, Davis D, Janc JW, Jeffery DA, Cheung H, Yu W.

Bioorg Med Chem Lett. 2005 Mar 1;15(5):1529-34.

PMID:
15713422
[PubMed - indexed for MEDLINE]
10.

Arylaminoethyl amides as novel non-covalent cathepsin K inhibitors.

Altmann E, Renaud J, Green J, Farley D, Cutting B, Jahnke W.

J Med Chem. 2002 Jun 6;45(12):2352-4.

PMID:
12036343
[PubMed - indexed for MEDLINE]
11.

Synthesis of peptidyl ene diones: selective inactivators of the cysteine proteinases.

Darkins P, Gilmore BF, Hawthorne SJ, Healy A, Moncrieff H, McCarthy N, McKervey MA, Brömme D, Pagano M, Walker B.

Chem Biol Drug Des. 2007 Mar;69(3):170-9.

PMID:
17441903
[PubMed - indexed for MEDLINE]
12.

3,4-disubstituted azetidinones as selective inhibitors of the cysteine protease cathepsin K. Exploring P2 elements for selectivity.

Setti EL, Davis D, Chung T, McCarter J.

Bioorg Med Chem Lett. 2003 Jun 16;13(12):2051-3.

PMID:
12781193
[PubMed - indexed for MEDLINE]
13.

Solid-phase synthesis of a combinatorial array of 1,3-bis(acylamino)-2-butanones, inhibitors of the cysteine proteases cathepsins K and L.

Yamashita DS, Dong X, Oh HJ, Brook CS, Tomaszek TA, Szewczuk L, Tew DG, Veber DF.

J Comb Chem. 1999 May-Jun;1(3):207-15.

PMID:
10746010
[PubMed - indexed for MEDLINE]
14.

Fluorescent nitrile-based inhibitors of cysteine cathepsins.

Frizler M, Mertens MD, Gütschow M.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7715-8. doi: 10.1016/j.bmcl.2012.09.086. Epub 2012 Oct 3.

PMID:
23122525
[PubMed - indexed for MEDLINE]
15.

Peptidomimetic 2-cyanopyrrolidines as potent selective cathepsin L inhibitors.

Yadav MR, Shinde AK, Chouhan BS, Giridhar R, Menard R.

J Enzyme Inhib Med Chem. 2008 Apr;23(2):190-7. doi: 10.1080/14756360701504842 .

PMID:
18343903
[PubMed - indexed for MEDLINE]
16.

Voltage-gated Sodium Channel Activity Promotes Cysteine Cathepsin-dependent Invasiveness and Colony Growth of Human Cancer Cells.

Gillet L, Roger S, Besson P, Lecaille F, Gore J, Bougnoux P, Lalmanach G, Le Guennec JY.

J Biol Chem. 2009 Mar 27;284(13):8680-91. doi: 10.1074/jbc.M806891200. Epub 2009 Jan 28.

PMID:
19176528
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Benzodioxocin-3-ones and N-acyl-3-amino-3-buten-2-ones: novel classes of cathepsin K cysteine protease inhibitors.

Yamashita DS, Xie R, Lin H, Wang B, Shi SD, Quinn CJ, Hemling ME, Hissong C, Tomaszek TA, Veber DF.

J Pept Res. 2004 Mar;63(3):265-9.

PMID:
15049838
[PubMed - indexed for MEDLINE]
18.

Discovery of selective and nonpeptidic cathepsin S inhibitors.

Irie O, Ehara T, Iwasaki A, Yokokawa F, Sakaki J, Hirao H, Kanazawa T, Teno N, Horiuchi M, Umemura I, Gunji H, Masuya K, Hitomi Y, Iwasaki G, Nonomura K, Tanabe K, Fukaya H, Kosaka T, Snell CR, Hallett A.

Bioorg Med Chem Lett. 2008 Jul 15;18(14):3959-62. doi: 10.1016/j.bmcl.2008.06.009. Epub 2008 Jun 10.

PMID:
18572405
[PubMed - indexed for MEDLINE]
19.

Solution phase synthesis of a combinatorial library of chalcones and flavones as potent cathepsin V inhibitors.

Alvim J Jr, Severino RP, Marques EF, Martinelli AM, Vieira PC, Fernandes JB, da Silva MF, Corrêa AG.

J Comb Chem. 2010 Sep 13;12(5):687-95. doi: 10.1021/cc100076k.

PMID:
20578711
[PubMed - indexed for MEDLINE]
20.

Arylaminoethyl amides as inhibitors of the cysteine protease cathepsin K-investigating P1' substituents.

Altmann E, Green J, Tintelnot-Blomley M.

Bioorg Med Chem Lett. 2003 Jun 16;13(12):1997-2001.

PMID:
12781182
[PubMed - indexed for MEDLINE]

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