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Scx+/Sox9+ progenitors contribute to the establishment of the junction between cartilage and tendon/ligament.

Sugimoto Y, Takimoto A, Akiyama H, Kist R, Scherer G, Nakamura T, Hiraki Y, Shukunami C.

Development. 2013 Jun;140(11):2280-8. doi: 10.1242/dev.096354. Epub 2013 Apr 24.


Tendon-bone attachment unit is formed modularly by a distinct pool of Scx- and Sox9-positive progenitors.

Blitz E, Sharir A, Akiyama H, Zelzer E.

Development. 2013 Jul;140(13):2680-90. doi: 10.1242/dev.093906. Epub 2013 May 29.


Direct conversion of tenocytes into chondrocytes by Sox9.

Takimoto A, Oro M, Hiraki Y, Shukunami C.

Exp Cell Res. 2012 Aug 1;318(13):1492-507. doi: 10.1016/j.yexcr.2012.04.002. Epub 2012 Apr 10.


Coordinated expression of scleraxis and Sox9 genes during embryonic development of tendons and cartilage.

Asou Y, Nifuji A, Tsuji K, Shinomiya K, Olson EN, Koopman P, Noda M.

J Orthop Res. 2002 Jul;20(4):827-33.


Scleraxis and E47 cooperatively regulate the Sox9-dependent transcription.

Furumatsu T, Shukunami C, Amemiya-Kudo M, Shimano H, Ozaki T.

Int J Biochem Cell Biol. 2010 Jan;42(1):148-56. doi: 10.1016/j.biocel.2009.10.003. Epub 2009 Oct 12.


Conversion of human bone marrow-derived mesenchymal stem cells into tendon progenitor cells by ectopic expression of scleraxis.

Alberton P, Popov C, Prägert M, Kohler J, Shukunami C, Schieker M, Docheva D.

Stem Cells Dev. 2012 Apr 10;21(6):846-58. doi: 10.1089/scd.2011.0150. Epub 2011 Oct 11.


Scleraxis is required for differentiation of the stapedius and tensor tympani tendons of the middle ear.

Wang L, Bresee CS, Jiang H, He W, Ren T, Schweitzer R, Brigande JV.

J Assoc Res Otolaryngol. 2011 Aug;12(4):407-21. doi: 10.1007/s10162-011-0264-5. Epub 2011 Mar 12.


Scleraxis positively regulates the expression of tenomodulin, a differentiation marker of tenocytes.

Shukunami C, Takimoto A, Oro M, Hiraki Y.

Dev Biol. 2006 Oct 1;298(1):234-47. Epub 2006 Jun 27.


Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons.

Murchison ND, Price BA, Conner DA, Keene DR, Olson EN, Tabin CJ, Schweitzer R.

Development. 2007 Jul;134(14):2697-708. Epub 2007 Jun 13.


Generation and characterization of ScxCre transgenic mice.

Sugimoto Y, Takimoto A, Hiraki Y, Shukunami C.

Genesis. 2013 Apr;51(4):275-83. doi: 10.1002/dvg.22372. Epub 2013 Mar 13.


The development of zebrafish tendon and ligament progenitors.

Chen JW, Galloway JL.

Development. 2014 May;141(10):2035-45. doi: 10.1242/dev.104067.


Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo.

Levay AK, Peacock JD, Lu Y, Koch M, Hinton RB Jr, Kadler KE, Lincoln J.

Circ Res. 2008 Oct 24;103(9):948-56. doi: 10.1161/CIRCRESAHA.108.177238. Epub 2008 Sep 18.


Generation of transgenic tendon reporters, ScxGFP and ScxAP, using regulatory elements of the scleraxis gene.

Pryce BA, Brent AE, Murchison ND, Tabin CJ, Schweitzer R.

Dev Dyn. 2007 Jun;236(6):1677-82.


Sox9-expressing precursors are the cellular origin of the cruciate ligament of the knee joint and the limb tendons.

Soeda T, Deng JM, de Crombrugghe B, Behringer RR, Nakamura T, Akiyama H.

Genesis. 2010 Nov;48(11):635-44. doi: 10.1002/dvg.20667. Epub 2010 Oct 7.


SOX9 is a major negative regulator of cartilage vascularization, bone marrow formation and endochondral ossification.

Hattori T, Müller C, Gebhard S, Bauer E, Pausch F, Schlund B, Bösl MR, Hess A, Surmann-Schmitt C, von der Mark H, de Crombrugghe B, von der Mark K.

Development. 2010 Mar;137(6):901-11. doi: 10.1242/dev.045203.


Expression and function of scleraxis in the developing auditory system.

Mann ZF, Chang W, Lee KY, King KA, Kelley MW.

PLoS One. 2013 Sep 13;8(9):e75521. doi: 10.1371/journal.pone.0075521. eCollection 2013.


Altered fate of tendon-derived stem cells isolated from a failed tendon-healing animal model of tendinopathy.

Rui YF, Lui PP, Wong YM, Tan Q, Chan KM.

Stem Cells Dev. 2013 Apr 1;22(7):1076-85. doi: 10.1089/scd.2012.0555. Epub 2012 Dec 16.


A somitic compartment of tendon progenitors.

Brent AE, Schweitzer R, Tabin CJ.

Cell. 2003 Apr 18;113(2):235-48.


Scx-transduced tendon-derived stem cells (tdscs) promoted better tendon repair compared to mock-transduced cells in a rat patellar tendon window injury model.

Tan C, Lui PP, Lee YW, Wong YM.

PLoS One. 2014 May 15;9(5):e97453. doi: 10.1371/journal.pone.0097453. eCollection 2014.

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