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The class III phosphatidylinositol 3-kinase PIK3C3/VPS34 regulates endocytosis and autophagosome-autolysosome formation in podocytes.

Bechtel W, Helmstädter M, Balica J, Hartleben B, Schell C, Huber TB.

Autophagy. 2013 Jul;9(7):1097-9. doi: 10.4161/auto.24634. Epub 2013 Apr 15.


PIK3C3/VPS34, the class III PtdIns 3-kinase, plays indispensable roles in the podocyte.

Chen JK.

Autophagy. 2013 Jun 1;9(6):923-4. doi: 10.4161/auto.24230. Epub 2013 Mar 21.


Vps34 deficiency reveals the importance of endocytosis for podocyte homeostasis.

Bechtel W, Helmstädter M, Balica J, Hartleben B, Kiefer B, Hrnjic F, Schell C, Kretz O, Liu S, Geist F, Kerjaschki D, Walz G, Huber TB.

J Am Soc Nephrol. 2013 Apr;24(5):727-43. doi: 10.1681/ASN.2012070700. Epub 2013 Mar 14.


The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila.

Juhász G, Hill JH, Yan Y, Sass M, Baehrecke EH, Backer JM, Neufeld TP.

J Cell Biol. 2008 May 19;181(4):655-66. doi: 10.1083/jcb.200712051. Epub 2008 May 12.


AMPK connects energy stress to PIK3C3/VPS34 regulation.

Kim J, Guan KL.

Autophagy. 2013 Jul;9(7):1110-1. doi: 10.4161/auto.24877. Epub 2013 May 2.


Mammalian PIK3C3/VPS34: the key to autophagic processing in liver and heart.

Jaber N, Dou Z, Lin RZ, Zhang J, Zong WX.

Autophagy. 2012 Apr;8(4):707-8. doi: 10.4161/auto.19627. Epub 2012 Apr 1.


Class III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasis.

Ikonomov OC, Sbrissa D, Venkatareddy M, Tisdale E, Garg P, Shisheva A.

Biochim Biophys Acta. 2015 May;1853(5):1240-50. doi: 10.1016/j.bbamcr.2015.01.008. Epub 2015 Jan 22.


Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function.

Jaber N, Dou Z, Chen JS, Catanzaro J, Jiang YP, Ballou LM, Selinger E, Ouyang X, Lin RZ, Zhang J, Zong WX.

Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):2003-8. doi: 10.1073/pnas.1112848109. Epub 2012 Jan 23.


Regulation of mammalian autophagy by class II and III PI 3-kinases through PI3P synthesis.

Devereaux K, Dall'Armi C, Alcazar-Roman A, Ogasawara Y, Zhou X, Wang F, Yamamoto A, De Camilli P, Di Paolo G.

PLoS One. 2013 Oct 3;8(10):e76405. doi: 10.1371/journal.pone.0076405. eCollection 2013.


Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy.

Yuan HX, Russell RC, Guan KL.

Autophagy. 2013 Dec;9(12):1983-95.


Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy.

Yang Y, Fiskus W, Yong B, Atadja P, Takahashi Y, Pandita TK, Wang HG, Bhalla KN.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6841-6. doi: 10.1073/pnas.1217692110. Epub 2013 Apr 8.


From a global view to focused examination: understanding cellular function of lipid kinase VPS34-Beclin 1 complex in autophagy.

Yue Z, Zhong Y.

J Mol Cell Biol. 2010 Dec;2(6):305-7. doi: 10.1093/jmcb/mjq028. Epub 2010 Sep 15.


Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels.

Zhong Y, Morris DH, Jin L, Patel MS, Karunakaran SK, Fu YJ, Matuszak EA, Weiss HL, Chait BT, Wang QJ.

J Biol Chem. 2014 Sep 19;289(38):26021-37. doi: 10.1074/jbc.M114.561134. Epub 2014 Aug 1.


Atg6/UVRAG/Vps34-containing lipid kinase complex is required for receptor downregulation through endolysosomal degradation and epithelial polarity during Drosophila wing development.

Lőrincz P, Lakatos Z, Maruzs T, Szatmári Z, Kis V, Sass M.

Biomed Res Int. 2014;2014:851349. doi: 10.1155/2014/851349. Epub 2014 May 21.


Beclin-1-interacting autophagy protein Atg14L targets the SNARE-associated protein Snapin to coordinate endocytic trafficking.

Kim HJ, Zhong Q, Sheng ZH, Yoshimori T, Liang C, Jung JU.

J Cell Sci. 2012 Oct 15;125(Pt 20):4740-50. doi: 10.1242/jcs.100339. Epub 2012 Jul 13.


Insulin activation of vacuolar protein sorting 34 mediates localized phosphatidylinositol 3-phosphate production at lamellipodia and activation of mTOR/S6K1.

Hirsch DS, Shen Y, Dokmanovic M, Yu J, Mohan N, Elzarrad MK, Wu WJ.

Cell Signal. 2014 Jun;26(6):1258-68. doi: 10.1016/j.cellsig.2014.02.009. Epub 2014 Feb 27.


The class IA phosphatidylinositol 3-kinase p110-beta subunit is a positive regulator of autophagy.

Dou Z, Chattopadhyay M, Pan JA, Guerriero JL, Jiang YP, Ballou LM, Yue Z, Lin RZ, Zong WX.

J Cell Biol. 2010 Nov 15;191(4):827-43. doi: 10.1083/jcb.201006056. Epub 2010 Nov 8.


Differential regulation of distinct Vps34 complexes by AMPK in nutrient stress and autophagy.

Kim J, Kim YC, Fang C, Russell RC, Kim JH, Fan W, Liu R, Zhong Q, Guan KL.

Cell. 2013 Jan 17;152(1-2):290-303. doi: 10.1016/j.cell.2012.12.016.


mTOR activates the VPS34-UVRAG complex to regulate autolysosomal tubulation and cell survival.

Munson MJ, Allen GF, Toth R, Campbell DG, Lucocq JM, Ganley IG.

EMBO J. 2015 Sep 2;34(17):2272-90. doi: 10.15252/embj.201590992. Epub 2015 Jul 2.


PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation.

Wu Y, Cheng S, Zhao H, Zou W, Yoshina S, Mitani S, Zhang H, Wang X.

EMBO Rep. 2014 Sep;15(9):973-81. doi: 10.15252/embr.201438618. Epub 2014 Aug 14.

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