Sort by

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 137


Insights into BAY 60-2770 activation and S-nitrosylation-dependent desensitization of soluble guanylyl cyclase via crystal structures of homologous nostoc H-NOX domain complexes.

Kumar V, Martin F, Hahn MG, Schaefer M, Stamler JS, Stasch JP, van den Akker F.

Biochemistry. 2013 May 21;52(20):3601-8. doi: 10.1021/bi301657w. Epub 2013 May 7.


Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase.

Martin F, Baskaran P, Ma X, Dunten PW, Schaefer M, Stasch JP, Beuve A, van den Akker F.

J Biol Chem. 2010 Jul 16;285(29):22651-7. doi: 10.1074/jbc.M110.111559. Epub 2010 May 12.


Desensitization of soluble guanylyl cyclase, the NO receptor, by S-nitrosylation.

Sayed N, Baskaran P, Ma X, van den Akker F, Beuve A.

Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12312-7. Epub 2007 Jul 16.


Insights into soluble guanylyl cyclase activation derived from improved heme-mimetics.

von Wantoch Rekowski M, Kumar V, Zhou Z, Moschner J, Marazioti A, Bantzi M, Spyroulias GA, van den Akker F, Giannis A, Papapetropoulos A.

J Med Chem. 2013 Nov 14;56(21):8948-52. doi: 10.1021/jm400539d. Epub 2013 Oct 24.


Probing domain interactions in soluble guanylate cyclase.

Derbyshire ER, Winter MB, Ibrahim M, Deng S, Spiro TG, Marletta MA.

Biochemistry. 2011 May 24;50(20):4281-90. doi: 10.1021/bi200341b. Epub 2011 May 3.


Nitric oxide and heat shock protein 90 activate soluble guanylate cyclase by driving rapid change in its subunit interactions and heme content.

Ghosh A, Stasch JP, Papapetropoulos A, Stuehr DJ.

J Biol Chem. 2014 May 30;289(22):15259-71. doi: 10.1074/jbc.M114.559393. Epub 2014 Apr 14.


Soluble guanylyl cyclase (sGC) degradation and impairment of nitric oxide-mediated responses in urethra from obese mice: reversal by the sGC activator BAY 60-2770.

Alexandre EC, Leiria LO, Silva FH, Mendes-Silvério CB, Calmasini FB, Davel AP, Mónica FZ, De Nucci G, Antunes E.

J Pharmacol Exp Ther. 2014 Apr;349(1):2-9. doi: 10.1124/jpet.113.211029. Epub 2014 Jan 13.


Crystal structure of the Alpha subunit PAS domain from soluble guanylyl cyclase.

Purohit R, Weichsel A, Montfort WR.

Protein Sci. 2013 Oct;22(10):1439-44. doi: 10.1002/pro.2331. Epub 2013 Sep 7.


Pressure-overload-induced subcellular relocalization/oxidation of soluble guanylyl cyclase in the heart modulates enzyme stimulation.

Tsai EJ, Liu Y, Koitabashi N, Bedja D, Danner T, Jasmin JF, Lisanti MP, Friebe A, Takimoto E, Kass DA.

Circ Res. 2012 Jan 20;110(2):295-303. doi: 10.1161/CIRCRESAHA.111.259242. Epub 2011 Nov 17.


Aspartate 102 in the heme domain of soluble guanylyl cyclase has a key role in NO activation.

Baskaran P, Heckler EJ, van den Akker F, Beuve A.

Biochemistry. 2011 May 24;50(20):4291-7. doi: 10.1021/bi2004087. Epub 2011 May 2.


Higher-order interactions bridge the nitric oxide receptor and catalytic domains of soluble guanylate cyclase.

Underbakke ES, Iavarone AT, Marletta MA.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6777-82. doi: 10.1073/pnas.1301934110. Epub 2013 Apr 9.


NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism.

Ma X, Sayed N, Beuve A, van den Akker F.

EMBO J. 2007 Jan 24;26(2):578-88. Epub 2007 Jan 11.


Theoretical investigation on the diatomic ligand migration process and ligand binding properties in non-O2-binding H-NOX domain.

Zhang Y, Liu L, Wu L, Li S, Li F, Li Z.

Proteins. 2013 Aug;81(8):1363-76. doi: 10.1002/prot.24279. Epub 2013 Apr 22.


Activation of haem-oxidized soluble guanylyl cyclase with BAY 60-2770 in human platelets lead to overstimulation of the cyclic GMP signaling pathway.

Mendes-Silverio CB, Leiria LO, Morganti RP, Anhê GF, Marcondes S, Mónica FZ, De Nucci G, Antunes E.

PLoS One. 2012;7(11):e47223. doi: 10.1371/journal.pone.0047223. Epub 2012 Nov 8.


Heme-assisted S-nitrosation desensitizes ferric soluble guanylate cyclase to nitric oxide.

Fernhoff NB, Derbyshire ER, Underbakke ES, Marletta MA.

J Biol Chem. 2012 Dec 14;287(51):43053-62. doi: 10.1074/jbc.M112.393892. Epub 2012 Oct 23.


Preconditioning with soluble guanylate cyclase activation prevents postischemic inflammation and reduces nitrate tolerance in heme oxygenase-1 knockout mice.

Wang WZ, Jones AW, Wang M, Durante W, Korthuis RJ.

Am J Physiol Heart Circ Physiol. 2013 Aug 15;305(4):H521-32. doi: 10.1152/ajpheart.00810.2012. Epub 2013 Jun 14.


NO-independent stimulation or activation of soluble guanylyl cyclase during early reperfusion limits infarct size.

Bice JS, Keim Y, Stasch JP, Baxter GF.

Cardiovasc Res. 2014 Feb 1;101(2):220-8. doi: 10.1093/cvr/cvt257. Epub 2013 Nov 20.


Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats.

Jabs A, Oelze M, Mikhed Y, Stamm P, Kröller-Schön S, Welschof P, Jansen T, Hausding M, Kopp M, Steven S, Schulz E, Stasch JP, Münzel T, Daiber A.

Vascul Pharmacol. 2015 Aug;71:181-91. doi: 10.1016/j.vph.2015.03.007. Epub 2015 Apr 11.


Distinct molecular requirements for activation or stabilization of soluble guanylyl cyclase upon haem oxidation-induced degradation.

Hoffmann LS, Schmidt PM, Keim Y, Schaefer S, Schmidt HH, Stasch JP.

Br J Pharmacol. 2009 Jul;157(5):781-95. doi: 10.1111/j.1476-5381.2009.00263.x. Epub 2009 May 18.


Molecular model of a soluble guanylyl cyclase fragment determined by small-angle X-ray scattering and chemical cross-linking.

Fritz BG, Roberts SA, Ahmed A, Breci L, Li W, Weichsel A, Brailey JL, Wysocki VH, Tama F, Montfort WR.

Biochemistry. 2013 Mar 5;52(9):1568-82. doi: 10.1021/bi301570m. Epub 2013 Feb 15.

Items per page

Supplemental Content

Write to the Help Desk