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Potential role of CYP2D6 in the central nervous system.

Cheng J, Zhen Y, Miksys S, Beyoğlu D, Krausz KW, Tyndale RF, Yu A, Idle JR, Gonzalez FJ.

Xenobiotica. 2013 Nov;43(11):973-84. doi: 10.3109/00498254.2013.791410. Epub 2013 Apr 25.


Effects of monoamine oxidase inhibitor and cytochrome P450 2D6 status on 5-methoxy-N,N-dimethyltryptamine metabolism and pharmacokinetics.

Shen HW, Wu C, Jiang XL, Yu AM.

Biochem Pharmacol. 2010 Jul 1;80(1):122-8. doi: 10.1016/j.bcp.2010.02.020. Epub 2010 Mar 3.


Polymorphic cytochrome P450 2D6: humanized mouse model and endogenous substrates.

Yu AM, Idle JR, Gonzalez FJ.

Drug Metab Rev. 2004 May;36(2):243-77. Review.


Human CYP2D6 and mouse CYP2Ds: organ distribution in a humanized mouse model.

Miksys SL, Cheung C, Gonzalez FJ, Tyndale RF.

Drug Metab Dispos. 2005 Oct;33(10):1495-502. Epub 2005 Jul 20.


Effects of CYP2D6 status on harmaline metabolism, pharmacokinetics and pharmacodynamics, and a pharmacogenetics-based pharmacokinetic model.

Wu C, Jiang XL, Shen HW, Yu AM.

Biochem Pharmacol. 2009 Sep 15;78(6):617-24. doi: 10.1016/j.bcp.2009.05.011. Epub 2009 May 13.


Modeling human cytochrome P450 2D6 metabolism and drug-drug interaction by a novel panel of knockout and humanized mouse lines.

Scheer N, Kapelyukh Y, McEwan J, Beuger V, Stanley LA, Rode A, Wolf CR.

Mol Pharmacol. 2012 Jan;81(1):63-72. doi: 10.1124/mol.111.075192. Epub 2011 Oct 11.


Regeneration of serotonin from 5-methoxytryptamine by polymorphic human CYP2D6.

Yu AM, Idle JR, Byrd LG, Krausz KW, Küpfer A, Gonzalez FJ.

Pharmacogenetics. 2003 Mar;13(3):173-81.


Cytochrome P450 2D6 as a model antigen.

Christen U, Holdener M, Hintermann E.

Dig Dis. 2010;28(1):80-5. doi: 10.1159/000282068. Epub 2010 May 7.


Anandamide oxidation by wild-type and polymorphically expressed CYP2B6 and CYP2D6.

Sridar C, Snider NT, Hollenberg PF.

Drug Metab Dispos. 2011 May;39(5):782-8. doi: 10.1124/dmd.110.036707. Epub 2011 Feb 2.


The CYP2D6 humanized mouse: effect of the human CYP2D6 transgene and HNF4alpha on the disposition of debrisoquine in the mouse.

Corchero J, Granvil CP, Akiyama TE, Hayhurst GP, Pimprale S, Feigenbaum L, Idle JR, Gonzalez FJ.

Mol Pharmacol. 2001 Dec;60(6):1260-7. Erratum in: Mol Pharmacol 2002 Jan;61(1):248.


Breaking tolerance to the natural human liver autoantigen cytochrome P450 2D6 by virus infection.

Holdener M, Hintermann E, Bayer M, Rhode A, Rodrigo E, Hintereder G, Johnson EF, Gonzalez FJ, Pfeilschifter J, Manns MP, Herrath Mv, Christen U.

J Exp Med. 2008 Jun 9;205(6):1409-22. doi: 10.1084/jem.20071859. Epub 2008 May 12.


Altered expression of small heterodimer partner governs cytochrome P450 (CYP) 2D6 induction during pregnancy in CYP2D6-humanized mice.

Koh KH, Pan X, Shen HW, Arnold SL, Yu AM, Gonzalez FJ, Isoherranen N, Jeong H.

J Biol Chem. 2014 Feb 7;289(6):3105-13. doi: 10.1074/jbc.M113.526798. Epub 2013 Dec 6.


Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice.

Felmlee MA, Lon HK, Gonzalez FJ, Yu AM.

Drug Metab Dispos. 2008 Feb;36(2):435-41. Epub 2007 Nov 29. Erratum in: Drug Metab Dispos. 2009 Jul;37(7):1563.


Krüppel-like factor 9 promotes hepatic cytochrome P450 2D6 expression during pregnancy in CYP2D6-humanized mice.

Koh KH, Pan X, Zhang W, McLachlan A, Urrutia R, Jeong H.

Mol Pharmacol. 2014 Dec;86(6):727-35. doi: 10.1124/mol.114.093666. Epub 2014 Sep 12.


Induction of the drug metabolizing enzyme CYP2D in monkey brain by chronic nicotine treatment.

Mann A, Miksys S, Lee A, Mash DC, Tyndale RF.

Neuropharmacology. 2008 Dec;55(7):1147-55. doi: 10.1016/j.neuropharm.2008.07.017. Epub 2008 Jul 19.


Recent examples on the clinical relevance of the CYP2D6 polymorphism and endogenous functionality of CYP2D6.

Haertter S.

Drug Metabol Drug Interact. 2013;28(4):209-16. doi: 10.1515/dmdi-2013-0032. Review.

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