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DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis.

Bergoglio V, Boyer AS, Walsh E, Naim V, Legube G, Lee MY, Rey L, Rosselli F, Cazaux C, Eckert KA, Hoffmann JS.

J Cell Biol. 2013 Apr 29;201(3):395-408. doi: 10.1083/jcb.201207066. Epub 2013 Apr 22.


Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication.

Rey L, Sidorova JM, Puget N, Boudsocq F, Biard DS, Monnat RJ Jr, Cazaux C, Hoffmann JS.

Mol Cell Biol. 2009 Jun;29(12):3344-54. doi: 10.1128/MCB.00115-09. Epub 2009 Apr 20.


Mechanism of replicative DNA polymerase delta pausing and a potential role for DNA polymerase kappa in common fragile site replication.

Walsh E, Wang X, Lee MY, Eckert KA.

J Mol Biol. 2013 Jan 23;425(2):232-43. doi: 10.1016/j.jmb.2012.11.016. Epub 2012 Nov 19.


The molecular chaperone Hsp90 regulates accumulation of DNA polymerase eta at replication stalling sites in UV-irradiated cells.

Sekimoto T, Oda T, Pozo FM, Murakumo Y, Masutani C, Hanaoka F, Yamashita T.

Mol Cell. 2010 Jan 15;37(1):79-89. doi: 10.1016/j.molcel.2009.12.015. Epub 2010 Jan 14.


Genome instability at common fragile sites: searching for the cause of their instability.

Franchitto A.

Biomed Res Int. 2013;2013:730714. doi: 10.1155/2013/730714. Epub 2013 Sep 5. Review.


Pol eta is required for DNA replication during nucleotide deprivation by hydroxyurea.

de Feraudy S, Limoli CL, Giedzinski E, Karentz D, Marti TM, Feeney L, Cleaver JE.

Oncogene. 2007 Aug 23;26(39):5713-21. Epub 2007 Mar 19.


Human DNA polymerase eta activity and translocation is regulated by phosphorylation.

Chen YW, Cleaver JE, Hatahet Z, Honkanen RE, Chang JY, Yen Y, Chou KM.

Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16578-83. doi: 10.1073/pnas.0808589105. Epub 2008 Oct 22.


Polymerase eta and p53 jointly regulate cell survival, apoptosis and Mre11 recombination during S phase checkpoint arrest after UV irradiation.

Cleaver JE, Bartholomew J, Char D, Crowley E, Feeney L, Limoli CL.

DNA Repair (Amst). 2002 Jan 22;1(1):41-57.


The role of DNA polymerase eta in UV mutational spectra.

Choi JH, Pfeifer GP.

DNA Repair (Amst). 2005 Feb 3;4(2):211-20.


Cell-type-specific replication initiation programs set fragility of the FRA3B fragile site.

Letessier A, Millot GA, Koundrioukoff S, Lachagès AM, Vogt N, Hansen RS, Malfoy B, Brison O, Debatisse M.

Nature. 2011 Feb 3;470(7332):120-3. doi: 10.1038/nature09745. Epub 2011 Jan 23.


A role for polymerase eta in the cellular tolerance to cisplatin-induced damage.

Albertella MR, Green CM, Lehmann AR, O'Connor MJ.

Cancer Res. 2005 Nov 1;65(21):9799-806.


Role of TLS DNA polymerases eta and kappa in processing naturally occurring structured DNA in human cells.

Bétous R, Rey L, Wang G, Pillaire MJ, Puget N, Selves J, Biard DS, Shin-ya K, Vasquez KM, Cazaux C, Hoffmann JS.

Mol Carcinog. 2009 Apr;48(4):369-78. doi: 10.1002/mc.20509.


Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA.

Speroni J, Federico MB, Mansilla SF, Soria G, Gottifredi V.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):7344-9. doi: 10.1073/pnas.1116345109. Epub 2012 Apr 23.


Rev3, the catalytic subunit of Polζ, is required for maintaining fragile site stability in human cells.

Bhat A, Andersen PL, Qin Z, Xiao W.

Nucleic Acids Res. 2013 Feb 1;41(4):2328-39. doi: 10.1093/nar/gks1442. Epub 2013 Jan 8.


Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint.

Zucca E, Bertoletti F, Wimmer U, Ferrari E, Mazzini G, Khoronenkova S, Grosse N, van Loon B, Dianov G, Hübscher U, Maga G.

Nucleic Acids Res. 2013 Jan 7;41(1):229-41. doi: 10.1093/nar/gks1016. Epub 2012 Oct 30.


DNA polymerase eta, a key protein in translesion synthesis in human cells.

Cruet-Hennequart S, Gallagher K, Sokòl AM, Villalan S, Prendergast AM, Carty MP.

Subcell Biochem. 2010;50:189-209. doi: 10.1007/978-90-481-3471-7_10. Review.


Role of DNA polymerase eta in the UV mutation spectrum in human cells.

Stary A, Kannouche P, Lehmann AR, Sarasin A.

J Biol Chem. 2003 May 23;278(21):18767-75. Epub 2003 Mar 18.


Homologous recombination mediates S-phase-dependent radioresistance in cells deficient in DNA polymerase eta.

Nicolay NH, Carter R, Hatch SB, Schultz N, Prevo R, McKenna WG, Helleday T, Sharma RA.

Carcinogenesis. 2012 Nov;33(11):2026-34. doi: 10.1093/carcin/bgs239. Epub 2012 Jul 20.


Replication stress activates DNA repair synthesis in mitosis.

Minocherhomji S, Ying S, Bjerregaard VA, Bursomanno S, Aleliunaite A, Wu W, Mankouri HW, Shen H, Liu Y, Hickson ID.

Nature. 2015 Dec 10;528(7581):286-90. doi: 10.1038/nature16139. Epub 2015 Dec 2.


Topoisomerase II- and condensin-dependent breakage of MEC1ATR-sensitive fragile sites occurs independently of spindle tension, anaphase, or cytokinesis.

Hashash N, Johnson AL, Cha RS.

PLoS Genet. 2012;8(10):e1002978. doi: 10.1371/journal.pgen.1002978. Epub 2012 Oct 25.

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