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Results: 1 to 20 of 134

1.

Elevated TRAF2/6 expression in Parkinson's disease is caused by the loss of Parkin E3 ligase activity.

Chung JY, Park HR, Lee SJ, Lee SH, Kim JS, Jung YS, Hwang SH, Ha NC, Seol WG, Lee J, Park BJ.

Lab Invest. 2013 Jun;93(6):663-76. doi: 10.1038/labinvest.2013.60. Epub 2013 Apr 22.

PMID:
23608757
[PubMed - indexed for MEDLINE]
Free Article
2.

[Etiology and pathogenesis of Parkinson's disease: from mitochondrial dysfunctions to familial Parkinson's disease].

Hattori N.

Rinsho Shinkeigaku. 2004 Apr-May;44(4-5):241-62. Review. Japanese.

PMID:
15287506
[PubMed - indexed for MEDLINE]
3.

Accumulation of the parkin substrate, FAF1, plays a key role in the dopaminergic neurodegeneration.

Sul JW, Park MY, Shin J, Kim YR, Yoo SE, Kong YY, Kwon KS, Lee YH, Kim E.

Hum Mol Genet. 2013 Apr 15;22(8):1558-73. doi: 10.1093/hmg/ddt006. Epub 2013 Jan 10.

PMID:
23307929
[PubMed - indexed for MEDLINE]
Free Article
4.

Parkin directly modulates 26S proteasome activity.

Um JW, Im E, Lee HJ, Min B, Yoo L, Yoo J, Lübbert H, Stichel-Gunkel C, Cho HS, Yoon JB, Chung KC.

J Neurosci. 2010 Sep 1;30(35):11805-14. doi: 10.1523/JNEUROSCI.2862-09.2010.

PMID:
20810900
[PubMed - indexed for MEDLINE]
Free Article
5.

WW domain containing E3 ubiquitin protein ligase 1 (WWP1) negatively regulates TLR4-mediated TNF-α and IL-6 production by proteasomal degradation of TNF receptor associated factor 6 (TRAF6).

Lin XW, Xu WC, Luo JG, Guo XJ, Sun T, Zhao XL, Fu ZJ.

PLoS One. 2013 Jun 17;8(6):e67633. doi: 10.1371/journal.pone.0067633. Print 2013.

PMID:
23799152
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

The regulatory role of α-synuclein and parkin in neuronal cell apoptosis; possible implications for the pathogenesis of Parkinson's disease.

Yasuda T, Mochizuki H.

Apoptosis. 2010 Nov;15(11):1312-21. doi: 10.1007/s10495-010-0486-8. Review.

PMID:
20221696
[PubMed - indexed for MEDLINE]
7.

Lipopolysaccharide and tumor necrosis factor regulate Parkin expression via nuclear factor-kappa B.

Tran TA, Nguyen AD, Chang J, Goldberg MS, Lee JK, Tansey MG.

PLoS One. 2011;6(8):e23660. doi: 10.1371/journal.pone.0023660. Epub 2011 Aug 17.

PMID:
21858193
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling.

Henn IH, Bouman L, Schlehe JS, Schlierf A, Schramm JE, Wegener E, Nakaso K, Culmsee C, Berninger B, Krappmann D, Tatzelt J, Winklhofer KF.

J Neurosci. 2007 Feb 21;27(8):1868-78.

PMID:
17314283
[PubMed - indexed for MEDLINE]
Free Article
9.

Ubiquitin-specific protease 4 (USP4) targets TRAF2 and TRAF6 for deubiquitination and inhibits TNFα-induced cancer cell migration.

Xiao N, Li H, Luo J, Wang R, Chen H, Chen J, Wang P.

Biochem J. 2012 Feb 1;441(3):979-86. doi: 10.1042/BJ20111358.

PMID:
22029577
[PubMed - indexed for MEDLINE]
Free Article
10.

Ubiquitin ligase CHIP induces TRAF2 proteasomal degradation and NF-κB inactivation to regulate breast cancer cell invasion.

Jang KW, Lee KH, Kim SH, Jin T, Choi EY, Jeon HJ, Kim E, Han YS, Chung JH.

J Cell Biochem. 2011 Dec;112(12):3612-20. doi: 10.1002/jcb.23292.

PMID:
21793045
[PubMed - indexed for MEDLINE]
11.

Parkin promotes degradation of the mitochondrial pro-apoptotic ARTS protein.

Kemeny S, Dery D, Loboda Y, Rovner M, Lev T, Zuri D, Finberg JP, Larisch S.

PLoS One. 2012;7(7):e38837. doi: 10.1371/journal.pone.0038837. Epub 2012 Jul 9.

PMID:
22792159
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function.

Wang C, Ko HS, Thomas B, Tsang F, Chew KC, Tay SP, Ho MW, Lim TM, Soong TW, Pletnikova O, Troncoso J, Dawson VL, Dawson TM, Lim KL.

Hum Mol Genet. 2005 Dec 15;14(24):3885-97. Epub 2005 Nov 8.

PMID:
16278233
[PubMed - indexed for MEDLINE]
Free Article
13.

Direct binding of TRAF2 and TRAF6 to TICAM-1/TRIF adaptor participates in activation of the Toll-like receptor 3/4 pathway.

Sasai M, Tatematsu M, Oshiumi H, Funami K, Matsumoto M, Hatakeyama S, Seya T.

Mol Immunol. 2010 Mar;47(6):1283-91. doi: 10.1016/j.molimm.2009.12.002. Epub 2010 Jan 4.

PMID:
20047764
[PubMed - indexed for MEDLINE]
14.

Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling.

Sha D, Chin LS, Li L.

Hum Mol Genet. 2010 Jan 15;19(2):352-63. doi: 10.1093/hmg/ddp501. Epub 2009 Oct 30.

PMID:
19880420
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Competition between TRAF2 and TRAF6 regulates NF-kappaB activation in human B lymphocytes.

Zhang W, Zhang X, Wu XL, He LS, Zeng XF, Crammer AC, Lipsky PE.

Chin Med Sci J. 2010 Mar;25(1):1-12.

PMID:
20449947
[PubMed - indexed for MEDLINE]
16.

Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease.

Shimura H, Schlossmacher MG, Hattori N, Frosch MP, Trockenbacher A, Schneider R, Mizuno Y, Kosik KS, Selkoe DJ.

Science. 2001 Jul 13;293(5528):263-9. Epub 2001 Jun 28.

PMID:
11431533
[PubMed - indexed for MEDLINE]
Free Article
17.

Parkin-associated Parkinson's disease.

von Coelln R, Dawson VL, Dawson TM.

Cell Tissue Res. 2004 Oct;318(1):175-84. Epub 2004 Jul 30. Review.

PMID:
15503153
[PubMed - indexed for MEDLINE]
18.

Inclusion body formation and neurodegeneration are parkin independent in a mouse model of alpha-synucleinopathy.

von Coelln R, Thomas B, Andrabi SA, Lim KL, Savitt JM, Saffary R, Stirling W, Bruno K, Hess EJ, Lee MK, Dawson VL, Dawson TM.

J Neurosci. 2006 Apr 5;26(14):3685-96.

PMID:
16597723
[PubMed - indexed for MEDLINE]
Free Article
19.

Parkin: much more than a simple ubiquitin ligase.

Alves da Costa C, Checler F.

Neurodegener Dis. 2012;10(1-4):49-51. doi: 10.1159/000332803. Epub 2011 Dec 23. Review.

PMID:
22204976
[PubMed - indexed for MEDLINE]
20.

Parkin and defective ubiquitination in Parkinson's disease.

Dawson TM.

J Neural Transm Suppl. 2006;(70):209-13. Review.

PMID:
17017531
[PubMed - indexed for MEDLINE]

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