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1.

Inhibitors for the hepatitis C virus RNA polymerase explored by SAR with advanced machine learning methods.

Weidlich IE, Filippov IV, Brown J, Kaushik-Basu N, Krishnan R, Nicklaus MC, Thorpe IF.

Bioorg Med Chem. 2013 Jun 1;21(11):3127-37. doi: 10.1016/j.bmc.2013.03.032. Epub 2013 Mar 29.

2.

Design and synthesis of L- and D-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase.

Patel BA, Krishnan R, Khadtare N, Gurukumar KR, Basu A, Arora P, Bhatt A, Patel MR, Dana D, Kumar S, Kaushik-Basu N, Talele TT.

Bioorg Med Chem. 2013 Jun 1;21(11):3262-71. doi: 10.1016/j.bmc.2013.03.041. Epub 2013 Mar 31.

3.

Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery and preliminary SAR of benzimidazole derivatives.

Beaulieu PL, Bös M, Bousquet Y, Fazal G, Gauthier J, Gillard J, Goulet S, LaPlante S, Poupart MA, Lefebvre S, McKercher G, Pellerin C, Austel V, Kukolj G.

Bioorg Med Chem Lett. 2004 Jan 5;14(1):119-24.

PMID:
14684311
4.

Synthesis and antiviral properties of novel tetracyclic nucleoside inhibitors of hepatitis C NS5B polymerase.

Di Francesco ME, Avolio S, Dessole G, Koch U, Pompei M, Pucci V, Rowley M, Summa V.

Nucleosides Nucleotides Nucleic Acids. 2012;31(8):592-607. doi: 10.1080/15257770.2012.707344.

PMID:
22908950
6.

Non-nucleoside inhibitors of the hepatitis C virus NS5B polymerase: discovery of benzimidazole 5-carboxylic amide derivatives with low-nanomolar potency.

Beaulieu PL, Bös M, Bousquet Y, DeRoy P, Fazal G, Gauthier J, Gillard J, Goulet S, McKercher G, Poupart MA, Valois S, Kukolj G.

Bioorg Med Chem Lett. 2004 Feb 23;14(4):967-71.

PMID:
15013003
7.

Discovery of novel tricyclic indole derived inhibitors of HCV NS5B RNA dependent RNA polymerase.

Venkatraman S, Velazquez F, Gavalas S, Wu W, Chen KX, Nair AG, Bennett F, Huang Y, Pinto P, Jiang Y, Selyutin O, Vibulbhan B, Zeng Q, Lesburg C, Duca J, Huang HC, Agrawal S, Jiang CK, Ferrari E, Li C, Kozlowski J, Rosenblum S, Shih NY, Njoroge FG.

Bioorg Med Chem. 2013 Apr 1;21(7):2007-17. doi: 10.1016/j.bmc.2013.01.024. Epub 2013 Jan 23.

PMID:
23434368
8.

Detailed computational study of the active site of the hepatitis C viral RNA polymerase to aid novel drug design.

Barakat KH, Law J, Prunotto A, Magee WC, Evans DH, Tyrrell DL, Tuszynski J, Houghton M.

J Chem Inf Model. 2013 Nov 25;53(11):3031-43. doi: 10.1021/ci4003969. Epub 2013 Oct 24.

PMID:
24116674
11.

Chemical genetics-based discovery of indole derivatives as HCV NS5B polymerase inhibitors.

Jin G, Lee S, Choi M, Son S, Kim GW, Oh JW, Lee C, Lee K.

Eur J Med Chem. 2014 Mar 21;75:413-25. doi: 10.1016/j.ejmech.2014.01.062. Epub 2014 Jan 31.

PMID:
24561671
12.

Non-nucleoside inhibitors of the hepatitis C virus NS5B RNA-dependant RNA polymerase: 2-aryl-3-heteroaryl-1,3-thiazolidin-4-one derivatives.

Rawal RK, Katti SB, Kaushik-Basu N, Arora P, Pan Z.

Bioorg Med Chem Lett. 2008 Dec 1;18(23):6110-4. doi: 10.1016/j.bmcl.2008.10.023. Epub 2008 Oct 8.

13.

Multiple e-pharmacophore modeling, 3D-QSAR, and high-throughput virtual screening of hepatitis C virus NS5B polymerase inhibitors.

Therese PJ, Manvar D, Kondepudi S, Battu MB, Sriram D, Basu A, Yogeeswari P, Kaushik-Basu N.

J Chem Inf Model. 2014 Feb 24;54(2):539-52. doi: 10.1021/ci400644r. Epub 2014 Feb 5.

PMID:
24460140
14.

Identification of novel inhibitors of HCV RNA-dependent RNA polymerase by pharmacophore-based virtual screening and in vitro evaluation.

Ryu K, Kim ND, Choi SI, Han CK, Yoon JH, No KT, Kim KH, Seong BL.

Bioorg Med Chem. 2009 Apr 15;17(8):2975-82. doi: 10.1016/j.bmc.2009.03.024. Epub 2009 Mar 18.

PMID:
19332375
16.

Synthesis and SAR optimization of diketo acid pharmacophore for HCV NS5B polymerase inhibition.

Bhatt A, Gurukumar KR, Basu A, Patel MR, Kaushik-Basu N, Talele TT.

Eur J Med Chem. 2011 Oct;46(10):5138-45. doi: 10.1016/j.ejmech.2011.08.028. Epub 2011 Aug 26.

17.

Discovery of a novel series of potent non-nucleoside inhibitors of hepatitis C virus NS5B.

Schoenfeld RC, Bourdet DL, Brameld KA, Chin E, de Vicente J, Fung A, Harris SF, Lee EK, Le Pogam S, Leveque V, Li J, Lui AS, Najera I, Rajyaguru S, Sangi M, Steiner S, Talamas FX, Taygerly JP, Zhao J.

J Med Chem. 2013 Oct 24;56(20):8163-82. doi: 10.1021/jm401266k. Epub 2013 Oct 10.

18.

Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase.

Sofia MJ, Chang W, Furman PA, Mosley RT, Ross BS.

J Med Chem. 2012 Mar 22;55(6):2481-531. doi: 10.1021/jm201384j. Epub 2012 Jan 23. Review. No abstract available.

PMID:
22185586
19.

Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides.

Cheng CC, Shipps GW Jr, Yang Z, Kawahata N, Lesburg CA, Duca JS, Bandouveres J, Bracken JD, Jiang CK, Agrawal S, Ferrari E, Huang HC.

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2119-24. doi: 10.1016/j.bmcl.2010.02.054. Epub 2010 Feb 18.

PMID:
20219368
20.

Evaluation of coumarin and neoflavone derivatives as HCV NS5B polymerase inhibitors.

Nichols DB, Leão RA, Basu A, Chudayeu M, de Moraes Pde F, Talele TT, Costa PR, Kaushik-Basu N.

Chem Biol Drug Des. 2013 May;81(5):607-14. doi: 10.1111/cbdd.12105. Epub 2013 Apr 4.

PMID:
23311976
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