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Results: 1 to 20 of 159

1.

Inactivation of TGF-β signaling and loss of PTEN cooperate to induce colon cancer in vivo.

Yu M, Trobridge P, Wang Y, Kanngurn S, Morris SM, Knoblaugh S, Grady WM.

Oncogene. 2014 Mar 20;33(12):1538-47. doi: 10.1038/onc.2013.102. Epub 2013 Apr 22.

PMID:
23604118
[PubMed - indexed for MEDLINE]
2.

Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation.

Muñoz NM, Upton M, Rojas A, Washington MK, Lin L, Chytil A, Sozmen EG, Madison BB, Pozzi A, Moon RT, Moses HL, Grady WM.

Cancer Res. 2006 Oct 15;66(20):9837-44.

PMID:
17047044
[PubMed - indexed for MEDLINE]
Free Article
3.

TGF-beta receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a beta-catenin-independent pathway.

Trobridge P, Knoblaugh S, Washington MK, Munoz NM, Tsuchiya KD, Rojas A, Song X, Ulrich CM, Sasazuki T, Shirasawa S, Grady WM.

Gastroenterology. 2009 May;136(5):1680-8.e7. doi: 10.1053/j.gastro.2009.01.066. Epub 2009 Feb 4.

PMID:
19208363
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations.

Grady WM, Willis JE, Trobridge P, Romero-Gallo J, Munoz N, Olechnowicz J, Ferguson K, Gautam S, Markowitz SD.

Int J Cancer. 2006 Feb 1;118(3):600-8.

PMID:
16108056
[PubMed - indexed for MEDLINE]
5.

Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer.

Biswas S, Chytil A, Washington K, Romero-Gallo J, Gorska AE, Wirth PS, Gautam S, Moses HL, Grady WM.

Cancer Res. 2004 Jul 15;64(14):4687-92.

PMID:
15256431
[PubMed - indexed for MEDLINE]
Free Article
6.

Transforming growth factor-beta signaling promotes hepatocarcinogenesis induced by p53 loss.

Morris SM, Baek JY, Koszarek A, Kanngurn S, Knoblaugh SE, Grady WM.

Hepatology. 2012 Jan;55(1):121-31. doi: 10.1002/hep.24653. Epub 2011 Dec 6.

PMID:
21898503
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

TGF-beta inactivation and TGF-alpha overexpression cooperate in an in vivo mouse model to induce hepatocellular carcinoma that recapitulates molecular features of human liver cancer.

Baek JY, Morris SM, Campbell J, Fausto N, Yeh MM, Grady WM.

Int J Cancer. 2010 Sep 1;127(5):1060-71. doi: 10.1002/ijc.25127.

PMID:
20020490
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Mutational inactivation of TGFBR2 in microsatellite unstable colon cancer arises from the cooperation of genomic instability and the clonal outgrowth of transforming growth factor beta resistant cells.

Biswas S, Trobridge P, Romero-Gallo J, Billheimer D, Myeroff LL, Willson JK, Markowitz SD, Grady WM.

Genes Chromosomes Cancer. 2008 Feb;47(2):95-106.

PMID:
17985359
[PubMed - indexed for MEDLINE]
9.

Intestinal epithelial-specific PTEN inactivation results in tumor formation.

Byun DS, Ahmed N, Nasser S, Shin J, Al-Obaidi S, Goel S, Corner GA, Wilson AJ, Flanagan DJ, Williams DS, Augenlicht LH, Vincan E, Mariadason JM.

Am J Physiol Gastrointest Liver Physiol. 2011 Nov;301(5):G856-64. doi: 10.1152/ajpgi.00178.2011. Epub 2011 Aug 11.

PMID:
21836055
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

TGF-β signaling alters the pattern of liver tumorigenesis induced by Pten inactivation.

Morris SM, Carter KT, Baek JY, Koszarek A, Yeh MM, Knoblaugh SE, Grady WM.

Oncogene. 2014 Aug 18;0. doi: 10.1038/onc.2014.258. [Epub ahead of print]

PMID:
25132272
[PubMed - as supplied by publisher]
11.

Colorectal carcinomas and PTEN/MMAC1 gene mutations.

Dicuonzo G, Angeletti S, Garcia-Foncillas J, Brugarolas A, Okrouzhnov Y, Santini D, Tonini G, Lorino G, De Cesaris M, Baldi A.

Clin Cancer Res. 2001 Dec;7(12):4049-53.

PMID:
11751500
[PubMed - indexed for MEDLINE]
Free Article
12.

TGF-beta receptor levels regulate the specificity of signaling pathway activation and biological effects of TGF-beta.

Rojas A, Padidam M, Cress D, Grady WM.

Biochim Biophys Acta. 2009 Jul;1793(7):1165-73. doi: 10.1016/j.bbamcr.2009.02.001. Epub 2009 Feb 12.

PMID:
19339207
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway.

Bian Y, Terse A, Du J, Hall B, Molinolo A, Zhang P, Chen W, Flanders KC, Gutkind JS, Wakefield LM, Kulkarni AB.

Cancer Res. 2009 Jul 15;69(14):5918-26. doi: 10.1158/0008-5472.CAN-08-4623. Epub 2009 Jul 7.

PMID:
19584284
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

COUP-TFII inhibits TGF-β-induced growth barrier to promote prostate tumorigenesis.

Qin J, Wu SP, Creighton CJ, Dai F, Xie X, Cheng CM, Frolov A, Ayala G, Lin X, Feng XH, Ittmann MM, Tsai SJ, Tsai MJ, Tsai SY.

Nature. 2013 Jan 10;493(7431):236-40. doi: 10.1038/nature11674. Epub 2012 Nov 28.

PMID:
23201680
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Aberrant transforming growth factor-beta signaling in azoxymethane-induced mouse colon tumors.

Guda K, Giardina C, Nambiar P, Cui H, Rosenberg DW.

Mol Carcinog. 2001 Aug;31(4):204-13.

PMID:
11536370
[PubMed - indexed for MEDLINE]
16.

Type III TGF-β receptor enhances colon cancer cell migration and anchorage-independent growth.

Gatza CE, Holtzhausen A, Kirkbride KC, Morton A, Gatza ML, Datto MB, Blobe GC.

Neoplasia. 2011 Aug;13(8):758-70.

PMID:
21847367
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Hepatocyte growth factor attenuates transforming growth factor-β-angiotensin II crosstalk through inhibition of the PTEN/Akt pathway.

Iekushi K, Taniyama Y, Kusunoki H, Azuma J, Sanada F, Okayama K, Koibuchi N, Iwabayashi M, Rakugi H, Morishita R.

Hypertension. 2011 Aug;58(2):190-6. doi: 10.1161/HYPERTENSIONAHA.111.173013. Epub 2011 Jun 13.

PMID:
21670418
[PubMed - indexed for MEDLINE]
Free Article
18.

PTEN and TNF-alpha regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB/Akt, and NF-kappaB-dependent pathway.

Kim S, Domon-Dell C, Wang Q, Chung DH, Di Cristofano A, Pandolfi PP, Freund JN, Evers BM.

Gastroenterology. 2002 Oct;123(4):1163-78.

PMID:
12360479
[PubMed - indexed for MEDLINE]
19.

Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity.

Hjelmeland AB, Hjelmeland MD, Shi Q, Hart JL, Bigner DD, Wang XF, Kontos CD, Rich JN.

Cancer Res. 2005 Dec 15;65(24):11276-81.

PMID:
16357132
[PubMed - indexed for MEDLINE]
Free Article
20.

Inactivation of TGF-beta signaling in hepatocytes results in an increased proliferative response after partial hepatectomy.

Romero-Gallo J, Sozmen EG, Chytil A, Russell WE, Whitehead R, Parks WT, Holdren MS, Her MF, Gautam S, Magnuson M, Moses HL, Grady WM.

Oncogene. 2005 Apr 21;24(18):3028-41.

PMID:
15735717
[PubMed - indexed for MEDLINE]

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