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Items: 1 to 20 of 168

1.

Ester prodrugs of acyclic nucleoside thiophosphonates compared to phosphonates: synthesis, antiviral activity and decomposition study.

Roux L, Priet S, Payrot N, Weck C, Fournier M, Zoulim F, Balzarini J, Canard B, Alvarez K.

Eur J Med Chem. 2013 May;63:869-81. doi: 10.1016/j.ejmech.2013.02.039. Epub 2013 Mar 14.

PMID:
23603046
2.

Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication.

Barral K, Weck C, Payrot N, Roux L, Durafour C, Zoulim F, Neyts J, Balzarini J, Canard B, Priet S, Alvarez K.

Eur J Med Chem. 2011 Sep;46(9):4281-8. doi: 10.1016/j.ejmech.2011.06.034. Epub 2011 Jul 1.

PMID:
21803462
3.

Some new acyclic nucleotide analogues as antiviral prodrugs: synthesis and bioactivities in vitro.

Tang YB, Peng ZG, Liu ZY, Li YP, Jiang JD, Li ZR.

Bioorg Med Chem Lett. 2007 Nov 15;17(22):6350-3. Epub 2007 Aug 31.

PMID:
17888662
4.

Metabolism and in vitro antiretroviral activities of bis(pivaloyloxymethyl) prodrugs of acyclic nucleoside phosphonates.

Srinivas RV, Robbins BL, Connelly MC, Gong YF, Bischofberger N, Fridland A.

Antimicrob Agents Chemother. 1993 Oct;37(10):2247-50.

5.

Antiviral potential of a new generation of acyclic nucleoside phosphonates, the 6-[2-(phosphonomethoxy)alkoxy]-2,4-diaminopyrimidines.

De Clercq E, Andrei G, Balzarini J, Leyssen P, Naesens L, Neyts J, Pannecouque C, Snoeck R, Ying C, Hocková D, Holý A.

Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):331-41.

PMID:
16247948
6.

Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety.

Tichý T, Andrei G, Snoeck R, Balzarini J, Dračínský M, Krečmerová M.

Eur J Med Chem. 2012 Sep;55:307-14. doi: 10.1016/j.ejmech.2012.07.027. Epub 2012 Jul 24.

PMID:
22858222
7.

Evaluation of nucleoside phosphonates and their analogs and prodrugs for inhibition of orthopoxvirus replication.

Keith KA, Hitchcock MJ, Lee WA, Holý A, Kern ER.

Antimicrob Agents Chemother. 2003 Jul;47(7):2193-8.

8.

Design, synthesis and evaluation of novel oxazaphosphorine prodrugs of 9-(2-phosphonomethoxyethyl)adenine (PMEA, adefovir) as potent HBV inhibitors.

Lu P, Liu J, Wang Y, Chen X, Yang Y, Ji R.

Bioorg Med Chem Lett. 2009 Dec 15;19(24):6918-21. doi: 10.1016/j.bmcl.2009.10.072. Epub 2009 Oct 21.

PMID:
19889538
9.

PMPA and PMEA prodrugs for the treatment of HIV infections and human papillomavirus (HPV) associated neoplasia and cancer.

Pertusati F, Hinsinger K, Flynn ÁS, Powell N, Tristram A, Balzarini J, McGuigan C.

Eur J Med Chem. 2014 May 6;78:259-68. doi: 10.1016/j.ejmech.2014.03.051. Epub 2014 Mar 17.

PMID:
24686012
10.

Chemokines, nitric oxide and antiarthritic effects of 9-(2-phosphonomethoxyethyl)adenine (Adefovir).

Zídek Z, Franková D, Holý A.

Eur J Pharmacol. 1999 Jul 2;376(1-2):91-100.

PMID:
10440094
11.

Synthesis, oral bioavailability determination, and in vitro evaluation of prodrugs of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA).

Starrett JE Jr, Tortolani DR, Russell J, Hitchcock MJ, Whiterock V, Martin JC, Mansuri MM.

J Med Chem. 1994 Jun 10;37(12):1857-64.

PMID:
8021925
12.
13.

Synthesis and antiviral evaluation of 9-(S)-[3-alkoxy-2-(phosphonomethoxy)propyl]nucleoside alkoxyalkyl esters: inhibitors of hepatitis C virus and HIV-1 replication.

Valiaeva N, Wyles DL, Schooley RT, Hwu JB, Beadle JR, Prichard MN, Hostetler KY.

Bioorg Med Chem. 2011 Aug 1;19(15):4616-25. doi: 10.1016/j.bmc.2011.06.009. Epub 2011 Jun 13.

14.

Ether lipid-ester prodrugs of acyclic nucleoside phosphonates: activity against adenovirus replication in vitro.

Hartline CB, Gustin KM, Wan WB, Ciesla SL, Beadle JR, Hostetler KY, Kern ER.

J Infect Dis. 2005 Feb 1;191(3):396-9. Epub 2004 Dec 29.

15.

Design and synthesis of novel bis(L-amino acid) ester prodrugs of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) with improved anti-HBV activity.

Fu X, Jiang S, Li C, Xin J, Yang Y, Ji R.

Bioorg Med Chem Lett. 2007 Jan 15;17(2):465-70. Epub 2006 Oct 12.

PMID:
17074481
16.

Cytotoxicity of pivoxil esters of antiviral acyclic nucleoside phosphonates: adefovir dipivoxil versus adefovir.

Zídek Z, Kmonícková E, Holý A.

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2005 Dec;149(2):315-9.

18.

Kinetic studies of the degradation of oxycarbonyloxymethyl prodrug of Adefovir and Tenofovir in solution.

Oliyai R, Yuan LC, Dahl T.

Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):1295-8.

PMID:
11563007
19.

[Design, synthesis and anti-hBV evaluation of adefovir mono-L-amino acid ester, mono non-steroidal anti-inflammatory drugs carboxylic ester prodrugs].

Fu XZ, Wang YL, Lan YY, Wang AM, Ou Y, Luo C, Li Y.

Yao Xue Xue Bao. 2010 Aug;45(8):1017-24. Chinese.

PMID:
21351588
20.

cycloSal-PMEA and cycloAmb-PMEA: potentially new phosphonate prodrugs based on the cycloSal-pronucleotide approach.

Meier C, Görbig U, Müller C, Balzarini J.

J Med Chem. 2005 Dec 15;48(25):8079-86.

PMID:
16335932
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