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Results: 1 to 20 of 135

1.

Nr5a2 heterozygosity sensitises to, and cooperates with, inflammation in KRas(G12V)-driven pancreatic tumourigenesis.

Flandez M, Cendrowski J, Cañamero M, Salas A, del Pozo N, Schoonjans K, Real FX.

Gut. 2014 Apr;63(4):647-55. doi: 10.1136/gutjnl-2012-304381. Epub 2013 Apr 18.

PMID:
23598351
[PubMed - indexed for MEDLINE]
2.

Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation.

von Figura G, Morris JP 4th, Wright CV, Hebrok M.

Gut. 2014 Apr;63(4):656-64. doi: 10.1136/gutjnl-2012-304287. Epub 2013 May 3.

PMID:
23645620
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Putting GWAS to the functional test: NR5A2 and pancreatic cancer risk.

Murtaugh LC.

Gut. 2014 Apr;63(4):535-6. doi: 10.1136/gutjnl-2013-305030. Epub 2013 Jun 12. No abstract available.

PMID:
23759730
[PubMed - indexed for MEDLINE]
4.

Numb regulates acinar cell dedifferentiation and survival during pancreatic damage and acinar-to-ductal metaplasia.

Greer RL, Staley BK, Liou A, Hebrok M.

Gastroenterology. 2013 Nov;145(5):1088-1097.e8. doi: 10.1053/j.gastro.2013.07.027. Epub 2013 Jul 25.

PMID:
23891977
[PubMed - indexed for MEDLINE]
5.

Inhibition of chronic pancreatitis and pancreatic intraepithelial neoplasia (PanIN) by capsaicin in LSL-KrasG12D/Pdx1-Cre mice.

Bai H, Li H, Zhang W, Matkowskyj KA, Liao J, Srivastava SK, Yang GY.

Carcinogenesis. 2011 Nov;32(11):1689-96. doi: 10.1093/carcin/bgr191. Epub 2011 Aug 22.

PMID:
21859833
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

A high-fat diet activates oncogenic Kras and COX2 to induce development of pancreatic ductal adenocarcinoma in mice.

Philip B, Roland CL, Daniluk J, Liu Y, Chatterjee D, Gomez SB, Ji B, Huang H, Wang H, Fleming JB, Logsdon CD, Cruz-Monserrate Z.

Gastroenterology. 2013 Dec;145(6):1449-58. doi: 10.1053/j.gastro.2013.08.018. Epub 2013 Aug 16.

PMID:
23958541
[PubMed - indexed for MEDLINE]
7.

Identification and manipulation of biliary metaplasia in pancreatic tumors.

Delgiorno KE, Hall JC, Takeuchi KK, Pan FC, Halbrook CJ, Washington MK, Olive KP, Spence JR, Sipos B, Wright CV, Wells JM, Crawford HC.

Gastroenterology. 2014 Jan;146(1):233-44.e5. doi: 10.1053/j.gastro.2013.08.053. Epub 2013 Aug 30.

PMID:
23999170
[PubMed - indexed for MEDLINE]
8.

The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma.

Martínez-Romero C, Rooman I, Skoudy A, Guerra C, Molero X, González A, Iglesias M, Lobato T, Bosch A, Barbacid M, Real FX, Hernández-Muñoz I.

J Pathol. 2009 Oct;219(2):205-13. doi: 10.1002/path.2585.

PMID:
19585519
[PubMed - indexed for MEDLINE]
9.

Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma.

Ijichi H, Chytil A, Gorska AE, Aakre ME, Bierie B, Tada M, Mohri D, Miyabayashi K, Asaoka Y, Maeda S, Ikenoue T, Tateishi K, Wright CV, Koike K, Omata M, Moses HL.

J Clin Invest. 2011 Oct;121(10):4106-17. doi: 10.1172/JCI42754. Epub 2011 Sep 19.

PMID:
21926469
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Early requirement of Rac1 in a mouse model of pancreatic cancer.

Heid I, Lubeseder-Martellato C, Sipos B, Mazur PK, Lesina M, Schmid RM, Siveke JT.

Gastroenterology. 2011 Aug;141(2):719-30, 730.e1-7. doi: 10.1053/j.gastro.2011.04.043. Epub 2011 Apr 28.

PMID:
21684285
[PubMed - indexed for MEDLINE]
11.

Disruption of p16 and activation of Kras in pancreas increase ductal adenocarcinoma formation and metastasis in vivo.

Qiu W, Sahin F, Iacobuzio-Donahue CA, Garcia-Carracedo D, Wang WM, Kuo CY, Chen D, Arking DE, Lowy AM, Hruban RH, Remotti HE, Su GH.

Oncotarget. 2011 Nov;2(11):862-73.

PMID:
22113502
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Concurrent PEDF deficiency and Kras mutation induce invasive pancreatic cancer and adipose-rich stroma in mice.

Grippo PJ, Fitchev PS, Bentrem DJ, Melstrom LG, Dangi-Garimella S, Krantz SB, Heiferman MJ, Chung C, Adrian K, Cornwell ML, Flesche JB, Rao SM, Talamonti MS, Munshi HG, Crawford SE.

Gut. 2012 Oct;61(10):1454-64. doi: 10.1136/gutjnl-2011-300821. Epub 2012 Jan 10.

PMID:
22234980
[PubMed - indexed for MEDLINE]
13.

Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer.

Lesina M, Kurkowski MU, Ludes K, Rose-John S, Treiber M, Klöppel G, Yoshimura A, Reindl W, Sipos B, Akira S, Schmid RM, Algül H.

Cancer Cell. 2011 Apr 12;19(4):456-69. doi: 10.1016/j.ccr.2011.03.009.

PMID:
21481788
[PubMed - indexed for MEDLINE]
Free Article
14.

Inactivation of TIF1gamma cooperates with Kras to induce cystic tumors of the pancreas.

Vincent DF, Yan KP, Treilleux I, Gay F, Arfi V, Kaniewski B, Marie JC, Lepinasse F, Martel S, Goddard-Leon S, Iovanna JL, Dubus P, Garcia S, Puisieux A, Rimokh R, Bardeesy N, Scoazec JY, Losson R, Bartholin L.

PLoS Genet. 2009 Jul;5(7):e1000575. doi: 10.1371/journal.pgen.1000575. Epub 2009 Jul 24. Erratum in: PLoS Genet. 2009 Aug;5(8). doi: 10.1371/annotation/7941c465-532f-4b42-b541-72d0810943b9. Kaniewsky, Bastien [corrected to Kaniewski, Bastien].

PMID:
19629168
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Snail cooperates with KrasG12D to promote pancreatic fibrosis.

Shields MA, Ebine K, Sahai V, Kumar K, Siddiqui K, Hwang RF, Grippo PJ, Munshi HG.

Mol Cancer Res. 2013 Sep;11(9):1078-87. doi: 10.1158/1541-7786.MCR-12-0637. Epub 2013 Jun 12.

PMID:
23761168
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Deletion of Rb accelerates pancreatic carcinogenesis by oncogenic Kras and impairs senescence in premalignant lesions.

Carrière C, Gore AJ, Norris AM, Gunn JR, Young AL, Longnecker DS, Korc M.

Gastroenterology. 2011 Sep;141(3):1091-101. doi: 10.1053/j.gastro.2011.05.041. Epub 2011 May 27.

PMID:
21699781
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression.

Ijichi H, Chytil A, Gorska AE, Aakre ME, Fujitani Y, Fujitani S, Wright CV, Moses HL.

Genes Dev. 2006 Nov 15;20(22):3147-60.

PMID:
17114585
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Oxidative stress induced by inactivation of TP53INP1 cooperates with KrasG12D to initiate and promote pancreatic carcinogenesis in the murine pancreas.

Al Saati T, Clerc P, Hanoun N, Peuget S, Lulka H, Gigoux V, Capilla F, Béluchon B, Couvelard A, Selves J, Buscail L, Carrier A, Dusetti N, Dufresne M.

Am J Pathol. 2013 Jun;182(6):1996-2004. doi: 10.1016/j.ajpath.2013.02.034. Epub 2013 Apr 8.

PMID:
23578383
[PubMed - indexed for MEDLINE]
Free Article
19.

Acute pancreatitis accelerates initiation and progression to pancreatic cancer in mice expressing oncogenic Kras in the nestin cell lineage.

Carrière C, Young AL, Gunn JR, Longnecker DS, Korc M.

PLoS One. 2011;6(11):e27725. doi: 10.1371/journal.pone.0027725. Epub 2011 Nov 28.

PMID:
22140463
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice.

Morris JP 4th, Cano DA, Sekine S, Wang SC, Hebrok M.

J Clin Invest. 2010 Feb;120(2):508-20. doi: 10.1172/JCI40045. Epub 2010 Jan 11.

PMID:
20071774
[PubMed - indexed for MEDLINE]
Free PMC Article

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