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Results: 1 to 20 of 112

1.

Targeting nitric oxide in the subacute restorative treatment of ischemic stroke.

Zhang RL, Zhang ZG, Chopp M.

Expert Opin Investig Drugs. 2013 Jul;22(7):843-51. doi: 10.1517/13543784.2013.793672. Epub 2013 Apr 18. Review.

PMID:
23597052
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Nitric oxide enhances angiogenesis via the synthesis of vascular endothelial growth factor and cGMP after stroke in the rat.

Zhang R, Wang L, Zhang L, Chen J, Zhu Z, Zhang Z, Chopp M.

Circ Res. 2003 Feb 21;92(3):308-13.

PMID:
12595343
[PubMed - indexed for MEDLINE]
Free Article
3.

Tadalafil, a long-acting type 5 phosphodiesterase isoenzyme inhibitor, improves neurological functional recovery in a rat model of embolic stroke.

Zhang L, Zhang Z, Zhang RL, Cui Y, LaPointe MC, Silver B, Chopp M.

Brain Res. 2006 Nov 6;1118(1):192-8. Epub 2006 Sep 7.

PMID:
16959227
[PubMed - indexed for MEDLINE]
4.

Nitric oxide-induced changes in endothelial expression of phosphodiesterases 2, 3, and 5.

Schankin CJ, Kruse LS, Reinisch VM, Jungmann S, Kristensen JC, Grau S, Ferrari U, Sinicina I, Goldbrunner R, Straube A, Kruuse C.

Headache. 2010 Mar;50(3):431-41. doi: 10.1111/j.1526-4610.2009.01512.x. Epub 2009 Sep 14.

PMID:
19751368
[PubMed - indexed for MEDLINE]
5.

Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic.

Zhang ZG, Chopp M.

Lancet Neurol. 2009 May;8(5):491-500. doi: 10.1016/S1474-4422(09)70061-4. Review.

PMID:
19375666
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Saving the ischemic penumbra: potential role for statins and phosphodiesterase inhibitors.

Sallustio F, Diomedi M, Centonze D, Stanzione P.

Curr Vasc Pharmacol. 2007 Oct;5(4):259-65. Review.

PMID:
17979792
[PubMed - indexed for MEDLINE]
7.

A nitric oxide donor induces neurogenesis and reduces functional deficits after stroke in rats.

Zhang R, Zhang L, Zhang Z, Wang Y, Lu M, Lapointe M, Chopp M.

Ann Neurol. 2001 Nov;50(5):602-11.

PMID:
11706966
[PubMed - indexed for MEDLINE]
8.

A phosphodiesterase-5 inhibitor vardenafil enhances angiogenesis through a protein kinase G-dependent hypoxia-inducible factor-1/vascular endothelial growth factor pathway.

Sahara M, Sata M, Morita T, Nakajima T, Hirata Y, Nagai R.

Arterioscler Thromb Vasc Biol. 2010 Jul;30(7):1315-24. doi: 10.1161/ATVBAHA.109.201327. Epub 2010 Apr 22.

PMID:
20413734
[PubMed - indexed for MEDLINE]
Free Article
9.

The role of platelets and their microparticles in rehabilitation of ischemic brain tissue.

Hayon Y, Shai E, Varon D, Leker RR.

CNS Neurol Disord Drug Targets. 2012 Nov 1;11(7):921-5. Review.

PMID:
23131157
[PubMed - indexed for MEDLINE]
10.

Phosphodiesterase 5 inhibition attenuates cerebral vasospasm and improves functional recovery after experimental subarachnoid hemorrhage.

Han BH, Vellimana AK, Zhou ML, Milner E, Zipfel GJ.

Neurosurgery. 2012 Jan;70(1):178-86; discussion 186-7. doi: 10.1227/NEU.0b013e31822ec2b0.

PMID:
21796010
[PubMed - indexed for MEDLINE]
11.

Kallikrein protects against ischemic stroke by inhibiting apoptosis and inflammation and promoting angiogenesis and neurogenesis.

Xia CF, Yin H, Yao YY, Borlongan CV, Chao L, Chao J.

Hum Gene Ther. 2006 Feb;17(2):206-19.

PMID:
16454654
[PubMed - indexed for MEDLINE]
12.

Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats.

Zhang R, Wang Y, Zhang L, Zhang Z, Tsang W, Lu M, Zhang L, Chopp M.

Stroke. 2002 Nov;33(11):2675-80.

PMID:
12411660
[PubMed - indexed for MEDLINE]
Free Article
13.

Thymosin beta4: a candidate for treatment of stroke?

Morris DC, Chopp M, Zhang L, Zhang ZG.

Ann N Y Acad Sci. 2010 Apr;1194:112-7. doi: 10.1111/j.1749-6632.2010.05469.x.

PMID:
20536457
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Novel peptide for attenuation of hypoxia-induced pulmonary hypertension via modulation of nitric oxide release and phosphodiesterase -5 activity.

Hu H, Zharikov S, Patel JM.

Peptides. 2012 May;35(1):78-85. doi: 10.1016/j.peptides.2012.03.009. Epub 2012 Mar 20.

PMID:
22465621
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Phosphodiesterase type 5 (PDE5) is co-localized with key proteins of the nitric oxide/cyclic GMP signaling in the human prostate.

Ückert S, Waldkirch ES, Merseburger AS, Kuczyk MA, Oelke M, Hedlund P.

World J Urol. 2013 Jun;31(3):609-14. doi: 10.1007/s00345-013-1048-9. Epub 2013 Mar 9.

PMID:
23475211
[PubMed - indexed for MEDLINE]
16.

Potential roles of HDAC inhibitors in mitigating ischemia-induced brain damage and facilitating endogenous regeneration and recovery.

Fessler EB, Chibane FL, Wang Z, Chuang DM.

Curr Pharm Des. 2013;19(28):5105-20. Review.

PMID:
23448466
[PubMed - indexed for MEDLINE]
17.

Phosphodiesterase type 5 inhibition reverts prostate fibroblast-to-myofibroblast trans-differentiation.

Zenzmaier C, Kern J, Sampson N, Heitz M, Plas E, Untergasser G, Berger P.

Endocrinology. 2012 Nov;153(11):5546-55. doi: 10.1210/en.2012-1431. Epub 2012 Sep 4.

PMID:
22948216
[PubMed - indexed for MEDLINE]
18.

Phosphodiesterase 5 (PDE5) inhibition, ANP and NO rapidly reduce epididymal duct contractions, but long-term PDE5 inhibition in vivo does not.

Mietens A, Tasch S, Feuerstacke C, Eichner G, Volkmann J, Schermuly RT, Grimminger F, Müller D, Middendorff R.

Mol Cell Endocrinol. 2012 Feb 26;349(2):145-53. doi: 10.1016/j.mce.2011.09.039. Epub 2011 Oct 2.

PMID:
21996373
[PubMed - indexed for MEDLINE]
19.

Phosphodiesterase 5 inhibitor, zaprinast, selectively increases cerebral blood flow in the ischemic penumbra in the rat brain.

Gao F, Sugita M, Nukui H.

Neurol Res. 2005 Sep;27(6):638-43.

PMID:
16157016
[PubMed - indexed for MEDLINE]
20.

Direct activation of PDE5 by cGMP: long-term effects within NO/cGMP signaling.

Mullershausen F, Friebe A, Feil R, Thompson WJ, Hofmann F, Koesling D.

J Cell Biol. 2003 Mar 3;160(5):719-27. Epub 2003 Feb 25.

PMID:
12604588
[PubMed - indexed for MEDLINE]
Free PMC Article

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