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Results: 1 to 20 of 112

1.

Kappa-opioid receptor-selective dicarboxylic ester-derived salvinorin A ligands.

Polepally PR, White K, Vardy E, Roth BL, Ferreira D, Zjawiony JK.

Bioorg Med Chem Lett. 2013 May 15;23(10):2860-2. doi: 10.1016/j.bmcl.2013.03.111. Epub 2013 Apr 4.

PMID:
23587424
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Salvinorin A, an active component of the hallucinogenic sage salvia divinorum is a highly efficacious kappa-opioid receptor agonist: structural and functional considerations.

Chavkin C, Sud S, Jin W, Stewart J, Zjawiony JK, Siebert DJ, Toth BA, Hufeisen SJ, Roth BL.

J Pharmacol Exp Ther. 2004 Mar;308(3):1197-203. Epub 2004 Jan 8.

PMID:
14718611
[PubMed - indexed for MEDLINE]
Free Article
3.

New neoclerodane diterpenoids isolated from the leaves of Salvia divinorum and their binding affinities for human kappa opioid receptors.

Lee DY, Ma Z, Liu-Chen LY, Wang Y, Chen Y, Carlezon WA Jr, Cohen B.

Bioorg Med Chem. 2005 Oct 1;13(19):5635-9.

PMID:
16084728
[PubMed - indexed for MEDLINE]
4.

Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist.

Roth BL, Baner K, Westkaemper R, Siebert D, Rice KC, Steinberg S, Ernsberger P, Rothman RB.

Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11934-9. Epub 2002 Aug 21.

PMID:
12192085
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Potential anxiolytic- and antidepressant-like effects of salvinorin A, the main active ingredient of Salvia divinorum, in rodents.

Braida D, Capurro V, Zani A, Rubino T, Viganò D, Parolaro D, Sala M.

Br J Pharmacol. 2009 Jul;157(5):844-53. doi: 10.1111/j.1476-5381.2009.00230.x. Epub 2009 May 5.

PMID:
19422370
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Synthetic studies of neoclerodane diterpenes from Salvia divinorum: preparation and opioid receptor activity of salvinicin analogues.

Simpson DS, Katavic PL, Lozama A, Harding WW, Parrish D, Deschamps JR, Dersch CM, Partilla JS, Rothman RB, Navarro H, Prisinzano TE.

J Med Chem. 2007 Jul 26;50(15):3596-603. Epub 2007 Jun 20.

PMID:
17580847
[PubMed - indexed for MEDLINE]
7.

Studies toward the pharmacophore of salvinorin A, a potent kappa opioid receptor agonist.

Munro TA, Rizzacasa MA, Roth BL, Toth BA, Yan F.

J Med Chem. 2005 Jan 27;48(2):345-8.

PMID:
15658846
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Synthetic studies of neoclerodane diterpenes from Salvia divinorum: semisynthesis of salvinicins A and B and other chemical transformations of salvinorin A.

Harding WW, Schmidt M, Tidgewell K, Kannan P, Holden KG, Gilmour B, Navarro H, Rothman RB, Prisinzano TE.

J Nat Prod. 2006 Jan;69(1):107-12.

PMID:
16441078
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Isolation and chemical modification of clerodane diterpenoids from Salvia species as potential agonists at the kappa-opioid receptor.

Li Y, Husbands SM, Mahon MF, Traynor JR, Rowan MG.

Chem Biodivers. 2007 Jul;4(7):1586-93.

PMID:
17638340
[PubMed - indexed for MEDLINE]
10.

Neuropharmacology of the naturally occurring kappa-opioid hallucinogen salvinorin A.

Cunningham CW, Rothman RB, Prisinzano TE.

Pharmacol Rev. 2011 Jun;63(2):316-47. doi: 10.1124/pr.110.003244. Epub 2011 Mar 28. Review.

PMID:
21444610
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouse.

Fantegrossi WE, Kugle KM, Valdes LJ 3rd, Koreeda M, Woods JH.

Behav Pharmacol. 2005 Dec;16(8):627-33.

PMID:
16286814
[PubMed - indexed for MEDLINE]
12.

The plant-derived hallucinogen, salvinorin A, produces kappa-opioid agonist-like discriminative effects in rhesus monkeys.

Butelman ER, Harris TJ, Kreek MJ.

Psychopharmacology (Berl). 2004 Mar;172(2):220-4. Epub 2003 Oct 30.

PMID:
14586540
[PubMed - indexed for MEDLINE]
13.

Inhibitory effect of salvinorin A, from Salvia divinorum, on ileitis-induced hypermotility: cross-talk between kappa-opioid and cannabinoid CB(1) receptors.

Capasso R, Borrelli F, Cascio MG, Aviello G, Huben K, Zjawiony JK, Marini P, Romano B, Di Marzo V, Capasso F, Izzo AA.

Br J Pharmacol. 2008 Nov;155(5):681-9. doi: 10.1038/bjp.2008.294. Epub 2008 Jul 14.

PMID:
18622408
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Differential signaling properties at the kappa opioid receptor of 12-epi-salvinorin A and its analogues.

Béguin C, Potuzak J, Xu W, Liu-Chen LY, Streicher JM, Groer CE, Bohn LM, Carlezon WA Jr, Cohen BM.

Bioorg Med Chem Lett. 2012 Jan 15;22(2):1023-6. doi: 10.1016/j.bmcl.2011.11.128. Epub 2011 Dec 7.

PMID:
22204910
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

[Salvinorin A and related diterpenes--biological activity and potential therapeutic uses].

Piekielna J, Fichna J, Janecka A.

Postepy Biochem. 2012;58(4):485-91. Review. Polish.

PMID:
23662442
[PubMed - indexed for MEDLINE]
16.

The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects.

Butelman ER, Rus S, Prisinzano TE, Kreek MJ.

Psychopharmacology (Berl). 2010 Jun;210(2):253-62. doi: 10.1007/s00213-009-1771-5. Epub 2010 Jan 19.

PMID:
20084367
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice.

Ansonoff MA, Zhang J, Czyzyk T, Rothman RB, Stewart J, Xu H, Zjwiony J, Siebert DJ, Yang F, Roth BL, Pintar JE.

J Pharmacol Exp Ther. 2006 Aug;318(2):641-8. Epub 2006 May 3.

PMID:
16672569
[PubMed - indexed for MEDLINE]
Free Article
18.

Selective natural kappa opioid and cannabinoid receptor agonists with a potential role in the treatment of gastrointestinal dysfunction.

Fichna J, Schicho R, Janecka A, Zjawiony JK, Storr M.

Drug News Perspect. 2009 Sep;22(7):383-92. doi: 10.1358/dnp.2009.22.7.1400219. Review.

PMID:
19890495
[PubMed - indexed for MEDLINE]
19.

Unconditioned behavioral effects of the powerful kappa-opioid hallucinogen salvinorin A in nonhuman primates: fast onset and entry into cerebrospinal fluid.

Butelman ER, Prisinzano TE, Deng H, Rus S, Kreek MJ.

J Pharmacol Exp Ther. 2009 Feb;328(2):588-97. doi: 10.1124/jpet.108.145342. Epub 2008 Nov 10.

PMID:
19001155
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Kappa opioid mediation of cannabinoid effects of the potent hallucinogen, salvinorin A, in rodents.

Walentiny DM, Vann RE, Warner JA, King LS, Seltzman HH, Navarro HA, Twine CE Jr, Thomas BF, Gilliam AF, Gilmour BP, Carroll FI, Wiley JL.

Psychopharmacology (Berl). 2010 Jun;210(2):275-84. doi: 10.1007/s00213-010-1827-6. Epub 2010 Mar 31.

PMID:
20354680
[PubMed - indexed for MEDLINE]
Free PMC Article

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