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Validation of high-sensitivity troponin I in a 2-hour diagnostic strategy to assess 30-day outcomes in emergency department patients with possible acute coronary syndrome.

Cullen L, Mueller C, Parsonage WA, Wildi K, Greenslade JH, Twerenbold R, Aldous S, Meller B, Tate JR, Reichlin T, Hammett CJ, Zellweger C, Ungerer JP, Rubini Gimenez M, Troughton R, Murray K, Brown AF, Mueller M, George P, Mosimann T, Flaws DF, Reiter M, Lamanna A, Haaf P, Pemberton CJ, Richards AM, Chu K, Reid CM, Peacock WF, Jaffe AS, Florkowski C, Deely JM, Than M.

J Am Coll Cardiol. 2013 Oct 1;62(14):1242-9. doi: 10.1016/j.jacc.2013.02.078. Epub 2013 Apr 10.


2-Hour accelerated diagnostic protocol to assess patients with chest pain symptoms using contemporary troponins as the only biomarker: the ADAPT trial.

Than M, Cullen L, Aldous S, Parsonage WA, Reid CM, Greenslade J, Flaws D, Hammett CJ, Beam DM, Ardagh MW, Troughton R, Brown AF, George P, Florkowski CM, Kline JA, Peacock WF, Maisel AS, Lim SH, Lamanna A, Richards AM.

J Am Coll Cardiol. 2012 Jun 5;59(23):2091-8. doi: 10.1016/j.jacc.2012.02.035. Epub 2012 May 9.


A new improved accelerated diagnostic protocol safely identifies low-risk patients with chest pain in the emergency department.

Aldous SJ, Richards MA, Cullen L, Troughton R, Than M.

Acad Emerg Med. 2012 May;19(5):510-6. doi: 10.1111/j.1553-2712.2012.01352.x.


Prospective validation of a modified thrombolysis in myocardial infarction risk score in emergency department patients with chest pain and possible acute coronary syndrome.

Hess EP, Perry JJ, Calder LA, Thiruganasambandamoorthy V, Body R, Jaffe A, Wells GA, Stiell IG.

Acad Emerg Med. 2010 Apr;17(4):368-75. doi: 10.1111/j.1553-2712.2010.00696.x.


Prospective external validation of an accelerated (2-h) acute coronary syndrome rule-out process using a contemporary troponin assay.

Kelly AM, Klim S.

Int J Emerg Med. 2014 Oct 16;7:42. doi: 10.1186/s12245-014-0042-3. eCollection 2014.


A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): a prospective observational validation study.

Than M, Cullen L, Reid CM, Lim SH, Aldous S, Ardagh MW, Peacock WF, Parsonage WA, Ho HF, Ko HF, Kasliwal RR, Bansal M, Soerianata S, Hu D, Ding R, Hua Q, Seok-Min K, Sritara P, Sae-Lee R, Chiu TF, Tsai KC, Chu FY, Chen WK, Chang WH, Flaws DF, George PM, Richards AM.

Lancet. 2011 Mar 26;377(9771):1077-84. doi: 10.1016/S0140-6736(11)60310-3.


Low-risk chest pain patients younger than 40 years do not benefit from admission and stress testing.

Napoli AM, Tran S, Wang J.

Crit Pathw Cardiol. 2013 Dec;12(4):201-3. doi: 10.1097/HPC.0b013e3182a75e3f.


Evaluation of the diagnostic performance of current and next-generation assays for cardiac troponin I in the BWH-TIMI ED Chest Pain Study.

Bonaca MP, Ruff CT, Kosowsky J, Conrad MJ, Murphy SA, Sabatine MS, Jarolim P, Morrow DA.

Eur Heart J Acute Cardiovasc Care. 2013 Sep;2(3):195-202. doi: 10.1177/2048872613486249.


Lipoprotein-associated phospholipase A2 for early risk stratification in patients with suspected acute coronary syndrome: a multi-marker approach: the North Wuerttemberg and Berlin Infarction Study-II (NOBIS-II).

Möckel M, Müller R, Vollert J, Müller C, Danne O, Gareis R, Störk T, Dietz R, Koenig W.

Clin Res Cardiol. 2007 Sep;96(9):604-12. Epub 2007 Jun 27.


Predictive value of a 4-hour accelerated diagnostic protocol in patients with suspected ischemic chest pain presenting to an emergency department.

Rao MP, Panduranga P, Al-Mukhaini M, Sulaiman K, Al-Jufaili M.

Oman Med J. 2012 May;27(3):207-11. doi: 10.5001/omj.2012.47.


Validation of the Vancouver Chest Pain Rule using troponin as the only biomarker: a prospective cohort study.

Greenslade JH, Cullen L, Than M, Aldous S, Chu K, Brown AF, Richards AM, Pemberton CJ, George P, Parsonage WA.

Am J Emerg Med. 2013 Jul;31(7):1103-7. doi: 10.1016/j.ajem.2013.04.016. Epub 2013 May 20.


A 2-hour diagnostic protocol for possible cardiac chest pain in the emergency department: a randomized clinical trial.

Than M, Aldous S, Lord SJ, Goodacre S, Frampton CM, Troughton R, George P, Florkowski CM, Ardagh M, Smyth D, Jardine DL, Peacock WF, Young J, Hamilton G, Deely JM, Cullen L, Richards AM.

JAMA Intern Med. 2014 Jan;174(1):51-8. doi: 10.1001/jamainternmed.2013.11362.


Growing pains with the use of high-sensitivity cardiac troponin assays.

Wu AH, Bolger AF, Hollander JE.

J Am Coll Cardiol. 2013 Oct 1;62(14):1250-1. doi: 10.1016/j.jacc.2013.02.075. Epub 2013 Apr 10. No abstract available.


Development and validation of the Emergency Department Assessment of Chest pain Score and 2 h accelerated diagnostic protocol.

Than M, Flaws D, Sanders S, Doust J, Glasziou P, Kline J, Aldous S, Troughton R, Reid C, Parsonage WA, Frampton C, Greenslade JH, Deely JM, Hess E, Sadiq AB, Singleton R, Shopland R, Vercoe L, Woolhouse-Williams M, Ardagh M, Bossuyt P, Bannister L, Cullen L.

Emerg Med Australas. 2014 Feb;26(1):34-44. doi: 10.1111/1742-6723.12164. Epub 2014 Jan 15.


The new Vancouver Chest Pain Rule using troponin as the only biomarker: an external validation study.

Cullen L, Greenslade JH, Than M, Brown AF, Hammett CJ, Lamanna A, Flaws DF, Chu K, Fowles LF, Parsonage WA.

Am J Emerg Med. 2014 Feb;32(2):129-34. doi: 10.1016/j.ajem.2013.10.021. Epub 2013 Oct 14.


Comparison of traditional cardiovascular risk models and coronary atherosclerotic plaque as detected by computed tomography for prediction of acute coronary syndrome in patients with acute chest pain.

Ferencik M, Schlett CL, Bamberg F, Truong QA, Nichols JH, Pena AJ, Shapiro MD, Rogers IS, Seneviratne S, Parry BA, Cury RC, Brady TJ, Brown DF, Nagurney JT, Hoffmann U.

Acad Emerg Med. 2012 Aug;19(8):934-42. doi: 10.1111/j.1553-2712.2012.01417.x. Epub 2012 Jul 31.

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