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Results: 1 to 20 of 125

1.

Menin epigenetically represses Hedgehog signaling in MEN1 tumor syndrome.

Gurung B, Feng Z, Iwamoto DV, Thiel A, Jin G, Fan CM, Ng JM, Curran T, Hua X.

Cancer Res. 2013 Apr 15;73(8):2650-8. doi: 10.1158/0008-5472.CAN-12-3158. Epub 2013 Apr 11.

PMID:
23580576
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Menin directly represses Gli1 expression independent of canonical Hedgehog signaling.

Gurung B, Feng Z, Hua X.

Mol Cancer Res. 2013 Oct;11(10):1215-22. doi: 10.1158/1541-7786.MCR-13-0170. Epub 2013 Aug 8.

PMID:
23928057
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Genome-wide characterization of menin-dependent H3K4me3 reveals a specific role for menin in the regulation of genes implicated in MEN1-like tumors.

Agarwal SK, Jothi R.

PLoS One. 2012;7(5):e37952. doi: 10.1371/journal.pone.0037952. Epub 2012 May 30.

PMID:
22666422
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Menin promotes the Wnt signaling pathway in pancreatic endocrine cells.

Chen G, A J, Wang M, Farley S, Lee LY, Lee LC, Sawicki MP.

Mol Cancer Res. 2008 Dec;6(12):1894-907. doi: 10.1158/1541-7786.MCR-07-2206.

PMID:
19074834
[PubMed - indexed for MEDLINE]
Free Article
5.

Menin is required for optimal processing of the microRNA let-7a.

Gurung B, Muhammad AB, Hua X.

J Biol Chem. 2014 Apr 4;289(14):9902-8. doi: 10.1074/jbc.M113.520692. Epub 2014 Feb 21.

PMID:
24563463
[PubMed - indexed for MEDLINE]
6.

Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c.

Karnik SK, Hughes CM, Gu X, Rozenblatt-Rosen O, McLean GW, Xiong Y, Meyerson M, Kim SK.

Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14659-64. Epub 2005 Sep 29.

PMID:
16195383
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

[The role and mechanism of high expression of cyclin B2 in MEN1 insulinoma].

Wu T, Huang XH.

Sheng Li Xue Bao. 2011 Dec 25;63(6):555-64. Chinese.

PMID:
22193451
[PubMed - indexed for MEDLINE]
Free Article
8.

Mechanisms of disease: multiple endocrine neoplasia type 1-relation to chromatin modifications and transcription regulation.

Dreijerink KM, Höppener JW, Timmers HM, Lips CJ.

Nat Clin Pract Endocrinol Metab. 2006 Oct;2(10):562-70. Review.

PMID:
17024155
[PubMed - indexed for MEDLINE]
9.

Menin expression is regulated by transforming growth factor beta signaling in leukemia cells.

Zhang H, Liu ZG, Hua XX.

Chin Med J (Engl). 2011 May;124(10):1556-62.

PMID:
21740816
[PubMed - indexed for MEDLINE]
Free Article
10.

Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1.

La P, Yang Y, Karnik SK, Silva AC, Schnepp RW, Kim SK, Hua X.

J Biol Chem. 2007 Oct 26;282(43):31332-40. Epub 2007 Aug 31.

PMID:
17766243
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Menin mediates epigenetic regulation via histone H3 lysine 9 methylation.

Yang YJ, Song TY, Park J, Lee J, Lim J, Jang H, Kim YN, Yang JH, Song Y, Choi A, Lee HY, Jo CH, Han JW, Kim ST, Youn HD, Cho EJ.

Cell Death Dis. 2013 Apr 11;4:e583. doi: 10.1038/cddis.2013.98.

PMID:
23579270
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Accelerated proliferation and differential global gene expression in pancreatic islets of five-week-old heterozygous Men1 mice: Men1 is a haploinsufficient suppressor.

Lejonklou MH, Barbu A, Stålberg P, Skogseid B.

Endocrinology. 2012 Jun;153(6):2588-98. doi: 10.1210/en.2011-1924. Epub 2012 Apr 4.

PMID:
22492302
[PubMed - indexed for MEDLINE]
13.

Menin, histone h3 methyltransferases, and regulation of cell proliferation: current knowledge and perspective.

Wu X, Hua X.

Curr Mol Med. 2008 Dec;8(8):805-15. Review.

PMID:
19075677
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Multiple endocrine neoplasia type 1: a chromatin writer's block.

Dreijerink KM, Lips CJ, Timmers HT.

J Intern Med. 2009 Jul;266(1):53-9. doi: 10.1111/j.1365-2796.2009.02115.x. Review.

PMID:
19522825
[PubMed - indexed for MEDLINE]
15.

Regulation of cyclin B2 expression and cell cycle G2/m transition by menin.

Wu T, Zhang X, Huang X, Yang Y, Hua X.

J Biol Chem. 2010 Jun 11;285(24):18291-300. doi: 10.1074/jbc.M110.106575. Epub 2010 Apr 19.

PMID:
20404349
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Mutation of tumor suppressor gene Men1 acutely enhances proliferation of pancreatic islet cells.

Schnepp RW, Chen YX, Wang H, Cash T, Silva A, Diehl JA, Brown E, Hua X.

Cancer Res. 2006 Jun 1;66(11):5707-15.

PMID:
16740708
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

The multiple endocrine neoplasia type 1 (MEN1) tumor suppressor regulates peroxisome proliferator-activated receptor gamma-dependent adipocyte differentiation.

Dreijerink KM, Varier RA, van Beekum O, Jeninga EH, Höppener JW, Lips CJ, Kummer JA, Kalkhoven E, Timmers HT.

Mol Cell Biol. 2009 Sep;29(18):5060-9. doi: 10.1128/MCB.01001-08. Epub 2009 Jul 13.

PMID:
19596783
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.

Chen YX, Yan J, Keeshan K, Tubbs AT, Wang H, Silva A, Brown EJ, Hess JL, Pear WS, Hua X.

Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):1018-23. Epub 2006 Jan 13.

PMID:
16415155
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Haploinsufficient and predominant expression of multiple endocrine neoplasia type 1 (MEN1)-related genes, MLL, p27Kip1 and p18Ink4C in endocrine organs.

Taguchi R, Yamada M, Horiguchi K, Tomaru T, Ozawa A, Shibusawa N, Hashimoto K, Okada S, Satoh T, Mori M.

Biochem Biophys Res Commun. 2011 Nov 18;415(2):378-83. doi: 10.1016/j.bbrc.2011.10.077. Epub 2011 Oct 21.

PMID:
22037578
[PubMed - indexed for MEDLINE]
20.

The role of tumor suppressor menin in IL-6 regulation in mouse islet tumor cells.

Song TY, Lim J, Kim B, Han JW, Youn HD, Cho EJ.

Biochem Biophys Res Commun. 2014 Aug 22;451(2):308-13. doi: 10.1016/j.bbrc.2014.07.113. Epub 2014 Aug 1.

PMID:
25088994
[PubMed - indexed for MEDLINE]

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