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Results: 1 to 20 of 338

1.

A transgenic Alzheimer rat with plaques, tau pathology, behavioral impairment, oligomeric aβ, and frank neuronal loss.

Cohen RM, Rezai-Zadeh K, Weitz TM, Rentsendorj A, Gate D, Spivak I, Bholat Y, Vasilevko V, Glabe CG, Breunig JJ, Rakic P, Davtyan H, Agadjanyan MG, Kepe V, Barrio JR, Bannykh S, Szekely CA, Pechnick RN, Town T.

J Neurosci. 2013 Apr 10;33(15):6245-56. doi: 10.1523/JNEUROSCI.3672-12.2013.

PMID:
23575824
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

A novel transgenic rat model with a full Alzheimer's-like amyloid pathology displays pre-plaque intracellular amyloid-beta-associated cognitive impairment.

Leon WC, Canneva F, Partridge V, Allard S, Ferretti MT, DeWilde A, Vercauteren F, Atifeh R, Ducatenzeiler A, Klein W, Szyf M, Alhonen L, Cuello AC.

J Alzheimers Dis. 2010;20(1):113-26. doi: 10.3233/JAD-2010-1349.

PMID:
20164597
[PubMed - indexed for MEDLINE]
3.

Alzheimer's disease and amyloid: culprit or coincidence?

Skaper SD.

Int Rev Neurobiol. 2012;102:277-316. doi: 10.1016/B978-0-12-386986-9.00011-9. Review.

PMID:
22748834
[PubMed - indexed for MEDLINE]
4.

APP transgenic modeling of Alzheimer's disease: mechanisms of neurodegeneration and aberrant neurogenesis.

Crews L, Rockenstein E, Masliah E.

Brain Struct Funct. 2010 Mar;214(2-3):111-26. doi: 10.1007/s00429-009-0232-6. Epub 2009 Nov 29. Review.

PMID:
20091183
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model.

Casas C, Sergeant N, Itier JM, Blanchard V, Wirths O, van der Kolk N, Vingtdeux V, van de Steeg E, Ret G, Canton T, Drobecq H, Clark A, Bonici B, Delacourte A, Benavides J, Schmitz C, Tremp G, Bayer TA, Benoit P, Pradier L.

Am J Pathol. 2004 Oct;165(4):1289-300.

PMID:
15466394
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Accelerated tau pathology with synaptic and neuronal loss in a novel triple transgenic mouse model of Alzheimer's disease.

Saul A, Sprenger F, Bayer TA, Wirths O.

Neurobiol Aging. 2013 Nov;34(11):2564-73. doi: 10.1016/j.neurobiolaging.2013.05.003. Epub 2013 Jun 5.

PMID:
23747045
[PubMed - indexed for MEDLINE]
7.

Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss.

Takeuchi A, Irizarry MC, Duff K, Saido TC, Hsiao Ashe K, Hasegawa M, Mann DM, Hyman BT, Iwatsubo T.

Am J Pathol. 2000 Jul;157(1):331-9. Erratum in: Am J Pathol 2000 Oct;157(4):1413.

PMID:
10880403
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Soluble Aβ levels correlate with cognitive deficits in the 12-month-old APPswe/PS1dE9 mouse model of Alzheimer's disease.

Zhang W, Hao J, Liu R, Zhang Z, Lei G, Su C, Miao J, Li Z.

Behav Brain Res. 2011 Sep 23;222(2):342-50. doi: 10.1016/j.bbr.2011.03.072. Epub 2011 Apr 14.

PMID:
21513747
[PubMed - indexed for MEDLINE]
9.

Genetic ablation of luteinizing hormone receptor improves the amyloid pathology in a mouse model of Alzheimer disease.

Lin J, Li X, Yuan F, Lin L, Cook CL, Rao ChV, Lei Z.

J Neuropathol Exp Neurol. 2010 Mar;69(3):253-61. doi: 10.1097/NEN.0b013e3181d072cf.

PMID:
20142765
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Intravenous delivery of targeted liposomes to amyloid-β pathology in APP/PSEN1 transgenic mice.

Tanifum EA, Dasgupta I, Srivastava M, Bhavane RC, Sun L, Berridge J, Pourgarzham H, Kamath R, Espinosa G, Cook SC, Eriksen JL, Annapragada A.

PLoS One. 2012;7(10):e48515. doi: 10.1371/journal.pone.0048515. Epub 2012 Oct 31.

PMID:
23119043
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics.

Rosenmann H, Grigoriadis N, Eldar-Levy H, Avital A, Rozenstein L, Touloumi O, Behar L, Ben-Hur T, Avraham Y, Berry E, Segal M, Ginzburg I, Abramsky O.

Exp Neurol. 2008 Jul;212(1):71-84. doi: 10.1016/j.expneurol.2008.03.007. Epub 2008 Mar 21.

PMID:
18490011
[PubMed - indexed for MEDLINE]
12.
13.

Cognitive impairment in the Tg6590 transgenic rat model of Alzheimer's disease.

Kloskowska E, Pham TM, Nilsson T, Zhu S, Oberg J, Codita A, Pedersen LA, Pedersen JT, Malkiewicz K, Winblad B, Folkesson R, Benedikz E.

J Cell Mol Med. 2010 Jun;14(6B):1816-23. doi: 10.1111/j.1582-4934.2009.00809.x. Epub 2009 Jun 16.

PMID:
19538474
[PubMed - indexed for MEDLINE]
14.

Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease.

Mori T, Koyama N, Arendash GW, Horikoshi-Sakuraba Y, Tan J, Town T.

Glia. 2010 Feb;58(3):300-14. doi: 10.1002/glia.20924.

PMID:
19705461
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Treatment with D3 removes amyloid deposits, reduces inflammation, and improves cognition in aged AβPP/PS1 double transgenic mice.

van Groen T, Kadish I, Funke SA, Bartnik D, Willbold D.

J Alzheimers Dis. 2013;34(3):609-20. doi: 10.3233/JAD-121792.

PMID:
23271316
[PubMed - indexed for MEDLINE]
16.

Chronic temporal lobe epilepsy is associated with enhanced Alzheimer-like neuropathology in 3×Tg-AD mice.

Yan XX, Cai Y, Shelton J, Deng SH, Luo XG, Oddo S, Laferla FM, Cai H, Rose GM, Patrylo PR.

PLoS One. 2012;7(11):e48782. doi: 10.1371/journal.pone.0048782. Epub 2012 Nov 14.

PMID:
23155407
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Transgenic mice as a model of pre-clinical Alzheimer's disease.

Ferretti MT, Partridge V, Leon WC, Canneva F, Allard S, Arvanitis DN, Vercauteren F, Houle D, Ducatenzeiler A, Klein WL, Glabe CG, Szyf M, Cuello AC.

Curr Alzheimer Res. 2011 Feb;8(1):4-23.

PMID:
21143159
[PubMed - indexed for MEDLINE]
18.

Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice.

Wirths O, Multhaup G, Czech C, Blanchard V, Moussaoui S, Tremp G, Pradier L, Beyreuther K, Bayer TA.

Neurosci Lett. 2001 Jun 22;306(1-2):116-20.

PMID:
11403971
[PubMed - indexed for MEDLINE]
19.

Disrupted cross-laminar cortical processing in β amyloid pathology precedes cell death.

Lison H, Happel MF, Schneider F, Baldauf K, Kerbstat S, Seelbinder B, Schneeberg J, Zappe M, Goldschmidt J, Budinger E, Schröder UH, Ohl FW, Schilling S, Demuth HU, Scheich H, Reymann KG, Rönicke R.

Neurobiol Dis. 2014 Mar;63:62-73. doi: 10.1016/j.nbd.2013.11.014. Epub 2013 Nov 27.

PMID:
24291517
[PubMed - in process]
20.

Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice.

Kocherhans S, Madhusudan A, Doehner J, Breu KS, Nitsch RM, Fritschy JM, Knuesel I.

J Neurosci. 2010 Jul 7;30(27):9228-40. doi: 10.1523/JNEUROSCI.0418-10.2010.

PMID:
20610758
[PubMed - indexed for MEDLINE]
Free Article

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