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The interaction between C5a and both C5aR and C5L2 receptors is required for production of G-CSF during acute inflammation.

Bosmann M, Haggadone MD, Zetoune FS, Sarma JV, Ward PA.

Eur J Immunol. 2013 Jul;43(7):1907-13. doi: 10.1002/eji.201243075. Epub 2013 May 13.


C5L2: a controversial receptor of complement anaphylatoxin, C5a.

Li R, Coulthard LG, Wu MC, Taylor SM, Woodruff TM.

FASEB J. 2013 Mar;27(3):855-64. doi: 10.1096/fj.12-220509. Epub 2012 Dec 13. Review.


C5L2 is required for C5a-triggered receptor internalization and ERK signaling.

Hsu WC, Yang FC, Lin CH, Hsieh SL, Chen NJ.

Cell Signal. 2014 Jul;26(7):1409-19. doi: 10.1016/j.cellsig.2014.02.021. Epub 2014 Mar 12.


TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2.

Raby AC, Holst B, Davies J, Colmont C, Laumonnier Y, Coles B, Shah S, Hall J, Topley N, Köhl J, Morgan BP, Labéta MO.

Eur J Immunol. 2011 Sep;41(9):2741-52. doi: 10.1002/eji.201041350. Epub 2011 Aug 4.


C5L2 and C5aR interaction in adipocytes and macrophages: insights into adipoimmunology.

Poursharifi P, Lapointe M, Pétrin D, Devost D, Gauvreau D, Hébert TE, Cianflone K.

Cell Signal. 2013 Apr;25(4):910-8. doi: 10.1016/j.cellsig.2012.12.010. Epub 2012 Dec 23.


Functional roles for C5a receptors in sepsis.

Rittirsch D, Flierl MA, Nadeau BA, Day DE, Huber-Lang M, Mackay CR, Zetoune FS, Gerard NP, Cianflone K, Köhl J, Gerard C, Sarma JV, Ward PA.

Nat Med. 2008 May;14(5):551-7. doi: 10.1038/nm1753. Epub 2008 May 4.


Functional roles for C5a and C5aR but not C5L2 in the pathogenesis of human and experimental cerebral malaria.

Kim H, Erdman LK, Lu Z, Serghides L, Zhong K, Dhabangi A, Musoke C, Gerard C, Cserti-Gazdewich C, Liles WC, Kain KC.

Infect Immun. 2014 Jan;82(1):371-9. doi: 10.1128/IAI.01246-13. Epub 2013 Nov 4.


Complement activation product C5a is a selective suppressor of TLR4-induced, but not TLR3-induced, production of IL-27(p28) from macrophages.

Bosmann M, Haggadone MD, Hemmila MR, Zetoune FS, Sarma JV, Ward PA.

J Immunol. 2012 May 15;188(10):5086-93. doi: 10.4049/jimmunol.1102914. Epub 2012 Apr 9.


Receptors for complement C5a. The importance of C5aR and the enigmatic role of C5L2.

Lee H, Whitfeld PL, Mackay CR.

Immunol Cell Biol. 2008 Feb;86(2):153-60. doi: 10.1038/sj.icb.7100166. Epub 2008 Jan 29. Review.


C5aR and C5L2 act in concert to balance immunometabolism in adipose tissue.

Poursharifi P, Lapointe M, Fisette A, Lu H, Roy C, Munkonda MN, Fairlie DP, Cianflone K.

Mol Cell Endocrinol. 2014 Jan 25;382(1):325-33. doi: 10.1016/j.mce.2013.10.019. Epub 2013 Oct 25.


C5L2, a nonsignaling C5A binding protein.

Okinaga S, Slattery D, Humbles A, Zsengeller Z, Morteau O, Kinrade MB, Brodbeck RM, Krause JE, Choe HR, Gerard NP, Gerard C.

Biochemistry. 2003 Aug 12;42(31):9406-15.


C5a regulates NKT and NK cell functions in sepsis.

Fusakio ME, Mohammed JP, Laumonnier Y, Hoebe K, Köhl J, Mattner J.

J Immunol. 2011 Dec 1;187(11):5805-12. doi: 10.4049/jimmunol.1100338. Epub 2011 Nov 4.


Absence of signaling into CD4⁺ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3⁺ regulatory T cells.

Strainic MG, Shevach EM, An F, Lin F, Medof ME.

Nat Immunol. 2013 Feb;14(2):162-71. doi: 10.1038/ni.2499. Epub 2012 Dec 23.


Complement dependency of cardiomyocyte release of mediators during sepsis.

Atefi G, Zetoune FS, Herron TJ, Jalife J, Bosmann M, Al-Aref R, Sarma JV, Ward PA.

FASEB J. 2011 Jul;25(7):2500-8. doi: 10.1096/fj.11-183236. Epub 2011 Apr 8.


Changes in the novel orphan, C5a receptor (C5L2), during experimental sepsis and sepsis in humans.

Huber-Lang M, Sarma JV, Rittirsch D, Schreiber H, Weiss M, Flierl M, Younkin E, Schneider M, Suger-Wiedeck H, Gebhard F, McClintock SD, Neff T, Zetoune F, Bruckner U, Guo RF, Monk PN, Ward PA.

J Immunol. 2005 Jan 15;174(2):1104-10.


Disruption of the complement anaphylatoxin receptor C5L2 exacerbates inflammation in allergic contact dermatitis.

Wang R, Lu B, Gerard C, Gerard NP.

J Immunol. 2013 Oct 15;191(8):4001-9. doi: 10.4049/jimmunol.1301626. Epub 2013 Sep 16.


The harmful role of c5a on innate immunity in sepsis.

Ward PA.

J Innate Immun. 2010;2(5):439-45. doi: 10.1159/000317194. Epub 2010 Jun 26. Review.


MyD88-dependent production of IL-17F is modulated by the anaphylatoxin C5a via the Akt signaling pathway.

Bosmann M, Patel VR, Russkamp NF, Pache F, Zetoune FS, Sarma JV, Ward PA.

FASEB J. 2011 Dec;25(12):4222-32. doi: 10.1096/fj.11-191205. Epub 2011 Aug 22.


Evidence for anti-inflammatory effects of C5a on the innate IL-17A/IL-23 axis.

Bosmann M, Sarma JV, Atefi G, Zetoune FS, Ward PA.

FASEB J. 2012 Apr;26(4):1640-51. doi: 10.1096/fj.11-199216. Epub 2011 Dec 27.


Immune cell-derived C3a and C5a costimulate human T cell alloimmunity.

Cravedi P, Leventhal J, Lakhani P, Ward SC, Donovan MJ, Heeger PS.

Am J Transplant. 2013 Oct;13(10):2530-9. doi: 10.1111/ajt.12405. Epub 2013 Sep 6.

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