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Proteolytic processing of the caspase-9 zymogen is required for apoptosome-mediated activation of caspase-9.

Hu Q, Wu D, Chen W, Yan Z, Shi Y.

J Biol Chem. 2013 May 24;288(21):15142-7. doi: 10.1074/jbc.M112.441568. Epub 2013 Apr 9.


The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer.

Malladi S, Challa-Malladi M, Fearnhead HO, Bratton SB.

EMBO J. 2009 Jul 8;28(13):1916-25. doi: 10.1038/emboj.2009.152. Epub 2009 Jun 4.


The holo-apoptosome: activation of procaspase-9 and interactions with caspase-3.

Yuan S, Yu X, Asara JM, Heuser JE, Ludtke SJ, Akey CW.

Structure. 2011 Aug 10;19(8):1084-96. doi: 10.1016/j.str.2011.07.001.


Apoptosome structure, assembly, and procaspase activation.

Yuan S, Akey CW.

Structure. 2013 Apr 2;21(4):501-15. doi: 10.1016/j.str.2013.02.024. Review.


A molecular view on signal transduction by the apoptosome.

Reubold TF, Eschenburg S.

Cell Signal. 2012 Jul;24(7):1420-5. doi: 10.1016/j.cellsig.2012.03.007. Epub 2012 Mar 13. Review.


Calcium blocks formation of apoptosome by preventing nucleotide exchange in Apaf-1.

Bao Q, Lu W, Rabinowitz JD, Shi Y.

Mol Cell. 2007 Jan 26;25(2):181-92.


A systems biology analysis of apoptosome formation and apoptosis execution supports allosteric procaspase-9 activation.

Würstle ML, Rehm M.

J Biol Chem. 2014 Sep 19;289(38):26277-89. doi: 10.1074/jbc.M114.590034. Epub 2014 Aug 8.


cIAP1 cooperatively inhibits procaspase-3 activation by the caspase-9 apoptosome.

Burke SP, Smith L, Smith JB.

J Biol Chem. 2010 Sep 24;285(39):30061-8. doi: 10.1074/jbc.M110.125955. Epub 2010 Jul 28.


Apoptosis: calling time on apoptosome activity.

Adrain C, Martin SJ.

Sci Signal. 2009 Oct 6;2(91):pe62. doi: 10.1126/scisignal.291pe62.


Regulation of the Apaf-1-caspase-9 apoptosome.

Bratton SB, Salvesen GS.

J Cell Sci. 2010 Oct 1;123(Pt 19):3209-14. doi: 10.1242/jcs.073643. Review. No abstract available.


A new model for the transition of APAF-1 from inactive monomer to caspase-activating apoptosome.

Reubold TF, Wohlgemuth S, Eschenburg S.

J Biol Chem. 2009 Nov 20;284(47):32717-24. doi: 10.1074/jbc.M109.014027. Epub 2009 Sep 30.


Amyloid β binds procaspase-9 to inhibit assembly of Apaf-1 apoptosome and intrinsic apoptosis pathway.

Sharoar MG, Islam MI, Shahnawaz M, Shin SY, Park IS.

Biochim Biophys Acta. 2014 Apr;1843(4):685-93. doi: 10.1016/j.bbamcr.2014.01.008. Epub 2014 Jan 12.


Pro-apoptotic proteins released from the mitochondria regulate the protein composition and caspase-processing activity of the native Apaf-1/caspase-9 apoptosome complex.

Twiddy D, Brown DG, Adrain C, Jukes R, Martin SJ, Cohen GM, MacFarlane M, Cain K.

J Biol Chem. 2004 May 7;279(19):19665-82. Epub 2004 Mar 1.


Defective molecular timer in the absence of nucleotides leads to inefficient caspase activation.

Zhang H, Gogada R, Yadav N, Lella RK, Badeaux M, Ayres M, Gandhi V, Tang DG, Chandra D.

PLoS One. 2011 Jan 27;6(1):e16379. doi: 10.1371/journal.pone.0016379.


Changes in Apaf-1 conformation that drive apoptosome assembly.

Yuan S, Topf M, Reubold TF, Eschenburg S, Akey CW.

Biochemistry. 2013 Apr 2;52(13):2319-27. doi: 10.1021/bi301721g. Epub 2013 Mar 22.


Jun kinase delays caspase-9 activation by interaction with the apoptosome.

Tran TH, Andreka P, Rodrigues CO, Webster KA, Bishopric NH.

J Biol Chem. 2007 Jul 13;282(28):20340-50. Epub 2007 May 4.


[The role of the apoptosome in the activation of procaspase-9].

Marek Ł.

Postepy Hig Med Dosw (Online). 2013 Feb 6;67:54-64. Review. Polish.


Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis.

Reubold TF, Wohlgemuth S, Eschenburg S.

Structure. 2011 Aug 10;19(8):1074-83. doi: 10.1016/j.str.2011.05.013.


Differential sensitivity to apoptosome apparatus activation in non-small cell lung carcinoma and the lung.

Moravcikova E, Krepela E, Prochazka J, Benkova K, Pauk N.

Int J Oncol. 2014 May;44(5):1443-54. doi: 10.3892/ijo.2014.2333. Epub 2014 Mar 10.


Caspase-9 activation by the apoptosome is not required for fas-mediated apoptosis in type II Jurkat cells.

Shawgo ME, Shelton SN, Robertson JD.

J Biol Chem. 2009 Nov 27;284(48):33447-55. doi: 10.1074/jbc.M109.032359. Epub 2009 Sep 16.

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