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Items: 1 to 20 of 148

1.

Silibinin inhibits tumor growth through downregulation of extracellular signal-regulated kinase and Akt in vitro and in vivo in human ovarian cancer cells.

Cho HJ, Suh DS, Moon SH, Song YJ, Yoon MS, Park do Y, Choi KU, Kim YK, Kim KH.

J Agric Food Chem. 2013 May 1;61(17):4089-96. doi: 10.1021/jf400192v. Epub 2013 Apr 18.

PMID:
23570653
2.

Silibinin induces cell death through reactive oxygen species-dependent downregulation of notch-1/ERK/Akt signaling in human breast cancer cells.

Kim TH, Woo JS, Kim YK, Kim KH.

J Pharmacol Exp Ther. 2014 May;349(2):268-78. doi: 10.1124/jpet.113.207563. Epub 2014 Jan 28.

3.

Silibinin inhibits glioma cell proliferation via Ca2+/ROS/MAPK-dependent mechanism in vitro and glioma tumor growth in vivo.

Kim KW, Choi CH, Kim TH, Kwon CH, Woo JS, Kim YK.

Neurochem Res. 2009 Aug;34(8):1479-90. doi: 10.1007/s11064-009-9935-6. Epub 2009 Mar 5.

PMID:
19263218
4.

The adenosine A3 receptor agonist Cl-IB-MECA induces cell death through Ca²⁺/ROS-dependent down regulation of ERK and Akt in A172 human glioma cells.

Kim TH, Kim YK, Woo JS.

Neurochem Res. 2012 Dec;37(12):2667-77. doi: 10.1007/s11064-012-0855-5. Epub 2012 Aug 10.

PMID:
22878643
5.

Lycii cortex radicis extract inhibits glioma tumor growth in vitro and in vivo through downregulation of the Akt/ERK pathway.

Jeong JC, Kim SJ, Kim YK, Kwon CH, Kim KH.

Oncol Rep. 2012 May;27(5):1467-74. doi: 10.3892/or.2012.1637. Epub 2012 Jan 16.

PMID:
22266745
6.

Kaempferol induces cell death through ERK and Akt-dependent down-regulation of XIAP and survivin in human glioma cells.

Jeong JC, Kim MS, Kim TH, Kim YK.

Neurochem Res. 2009 May;34(5):991-1001. doi: 10.1007/s11064-008-9868-5. Epub 2008 Oct 24.

PMID:
18949556
7.

Underlying mechanism of quercetin-induced cell death in human glioma cells.

Kim EJ, Choi CH, Park JY, Kang SK, Kim YK.

Neurochem Res. 2008 Jun;33(6):971-9. doi: 10.1007/s11064-007-9416-8. Epub 2008 Mar 6.

PMID:
18322795
9.
10.

Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling.

Mallikarjuna G, Dhanalakshmi S, Singh RP, Agarwal C, Agarwal R.

Cancer Res. 2004 Sep 1;64(17):6349-56.

11.

Mulberry fruit (Moris fructus) extracts induce human glioma cell death in vitro through ROS-dependent mitochondrial pathway and inhibits glioma tumor growth in vivo.

Jeong JC, Jang SW, Kim TH, Kwon CH, Kim YK.

Nutr Cancer. 2010;62(3):402-12. doi: 10.1080/01635580903441287.

PMID:
20358478
12.

Silibinin inhibits cell growth and induces apoptosis by caspase activation, down-regulating survivin and blocking EGFR-ERK activation in renal cell carcinoma.

Li L, Gao Y, Zhang L, Zeng J, He D, Sun Y.

Cancer Lett. 2008 Dec 8;272(1):61-9. doi: 10.1016/j.canlet.2008.06.033. Epub 2008 Aug 23.

PMID:
18723275
13.

Different effect of protein kinase B/Akt and extracellular signal-regulated kinase inhibition on trichostatin A-induced apoptosis in epithelial ovarian carcinoma cell lines.

Jang ER, Kim YJ, Myung SC, Kim W, Lee CS.

Mol Cell Biochem. 2011 Jul;353(1-2):1-11. doi: 10.1007/s11010-011-0768-7. Epub 2011 Mar 6.

PMID:
21380726
14.

Inhibitory effect of silibinin on EGFR signal-induced renal cell carcinoma progression via suppression of the EGFR/MMP-9 signaling pathway.

Liang L, Li L, Zeng J, Gao Y, Chen YL, Wang ZQ, Wang XY, Chang LS, He D.

Oncol Rep. 2012 Sep;28(3):999-1005. doi: 10.3892/or.2012.1874. Epub 2012 Jun 19.

PMID:
22736024
15.

Resveratrol downregulates Akt/GSK and ERK signalling pathways in OVCAR-3 ovarian cancer cells.

Vergara D, Simeone P, Toraldo D, Del Boccio P, Vergaro V, Leporatti S, Pieragostino D, Tinelli A, De Domenico S, Alberti S, Urbani A, Salzet M, Santino A, Maffia M.

Mol Biosyst. 2012 Apr;8(4):1078-87. doi: 10.1039/c2mb05486h. Epub 2012 Jan 10.

PMID:
22234583
16.

Interruption of mitochondrial complex IV activity and cytochrome c expression activated O₂·⁻-mediated cell survival in silibinin-treated human melanoma A375-S2 cells via IGF-1R-PI3K-Akt and IGF-1R-PLC γ-PKC pathways.

Jiang YY, Huang H, Wang HJ, Wu D, Yang R, Tashiro S, Onodera S, Ikejima T.

Eur J Pharmacol. 2011 Oct 1;668(1-2):78-87. doi: 10.1016/j.ejphar.2011.06.007. Epub 2011 Jun 17.

PMID:
21703257
17.

Butein inhibits the proliferation of breast cancer cells through generation of reactive oxygen species and modulation of ERK and p38 activities.

Yang LH, Ho YJ, Lin JF, Yeh CW, Kao SH, Hsu LS.

Mol Med Rep. 2012 Nov;6(5):1126-32. doi: 10.3892/mmr.2012.1023. Epub 2012 Aug 7.

PMID:
22895548
18.

Effects and mechanisms of silibinin on human hepatocellular carcinoma xenografts in nude mice.

Cui W, Gu F, Hu KQ.

World J Gastroenterol. 2009 Apr 28;15(16):1943-50.

20.

Energy deprivation by silibinin in colorectal cancer cells: a double-edged sword targeting both apoptotic and autophagic machineries.

Raina K, Agarwal C, Wadhwa R, Serkova NJ, Agarwal R.

Autophagy. 2013 May;9(5):697-713. doi: 10.4161/auto.23960. Epub 2013 Feb 27.

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