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Results: 1 to 20 of 125

1.

Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV.

Mitton-Fry MJ, Brickner SJ, Hamel JC, Brennan L, Casavant JM, Chen M, Chen T, Ding X, Driscoll J, Hardink J, Hoang T, Hua E, Huband MD, Maloney M, Marfat A, McCurdy SP, McLeod D, Plotkin M, Reilly U, Robinson S, Schafer J, Shepard RM, Smith JF, Stone GG, Subramanyam C, Yoon K, Yuan W, Zaniewski RP, Zook C.

Bioorg Med Chem Lett. 2013 May 15;23(10):2955-61. doi: 10.1016/j.bmcl.2013.03.047. Epub 2013 Mar 21.

PMID:
23566517
[PubMed - indexed for MEDLINE]
2.

Selenophene-containing inhibitors of type IIA bacterial topoisomerases.

Wiles JA, Phadke AS, Bradbury BJ, Pucci MJ, Thanassi JA, Deshpande M.

J Med Chem. 2011 May 12;54(9):3418-25. doi: 10.1021/jm2002124. Epub 2011 Apr 13.

PMID:
21443219
[PubMed - indexed for MEDLINE]
3.

Dual targeting of DNA gyrase and topoisomerase IV: target interactions of heteroaryl isothiazolones in Staphylococcus aureus.

Cheng J, Thanassi JA, Thoma CL, Bradbury BJ, Deshpande M, Pucci MJ.

Antimicrob Agents Chemother. 2007 Jul;51(7):2445-53. Epub 2007 May 14.

PMID:
17502409
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Discovery of kibdelomycin, a potent new class of bacterial type II topoisomerase inhibitor by chemical-genetic profiling in Staphylococcus aureus.

Phillips JW, Goetz MA, Smith SK, Zink DL, Polishook J, Onishi R, Salowe S, Wiltsie J, Allocco J, Sigmund J, Dorso K, Lee S, Skwish S, de la Cruz M, Martín J, Vicente F, Genilloud O, Lu J, Painter RE, Young K, Overbye K, Donald RG, Singh SB.

Chem Biol. 2011 Aug 26;18(8):955-65. doi: 10.1016/j.chembiol.2011.06.011.

PMID:
21867911
[PubMed - indexed for MEDLINE]
Free Article
5.

Design, synthesis and biological evaluation of α-substituted isonipecotic acid benzothiazole analogues as potent bacterial type II topoisomerase inhibitors.

Axford LC, Agarwal PK, Anderson KH, Andrau LN, Atherall J, Barker S, Bennett JM, Blair M, Collins I, Czaplewski LG, Davies DT, Gannon CT, Kumar D, Lancett P, Logan A, Lunniss CJ, Mitchell DR, Offermann DA, Palmer JT, Palmer N, Pitt GR, Pommier S, Price D, Narasinga Rao B, Saxena R, Shukla T, Singh AK, Singh M, Srivastava A, Steele C, Stokes NR, Thomaides-Brears HB, Tyndall EM, Watson D, Haydon DJ.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6598-603. doi: 10.1016/j.bmcl.2013.10.058. Epub 2013 Nov 4.

PMID:
24239017
[PubMed - indexed for MEDLINE]
6.

Symmetric bis-benzimidazoles are potent anti-staphylococcal agents with dual inhibitory mechanisms against DNA gyrase.

Dale AG, Hinds J, Mann J, Taylor PW, Neidle S.

Biochemistry. 2012 Jul 24;51(29):5860-71. doi: 10.1021/bi300645n. Epub 2012 Jul 12.

PMID:
22746203
[PubMed - indexed for MEDLINE]
7.

Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics.

Alt S, Mitchenall LA, Maxwell A, Heide L.

J Antimicrob Chemother. 2011 Sep;66(9):2061-9. doi: 10.1093/jac/dkr247. Epub 2011 Jun 21.

PMID:
21693461
[PubMed - indexed for MEDLINE]
Free Article
8.

Kibdelomycin A, a congener of kibdelomycin, derivatives and their antibacterial activities.

Singh SB, Goetz MA, Smith SK, Zink DL, Polishook J, Onishi R, Salowe S, Wiltsie J, Allocco J, Sigmund J, Dorso K, de la Cruz M, Martín J, Vicente F, Genilloud O, Donald RG, Phillips JW.

Bioorg Med Chem Lett. 2012 Dec 1;22(23):7127-30. doi: 10.1016/j.bmcl.2012.09.071. Epub 2012 Oct 2.

PMID:
23084277
[PubMed - indexed for MEDLINE]
9.

Synthesis and antibacterial activity of a novel series of potent DNA gyrase inhibitors. Pyrazole derivatives.

Tanitame A, Oyamada Y, Ofuji K, Fujimoto M, Iwai N, Hiyama Y, Suzuki K, Ito H, Terauchi H, Kawasaki M, Nagai K, Wachi M, Yamagishi J.

J Med Chem. 2004 Jul 1;47(14):3693-6.

PMID:
15214796
[PubMed - indexed for MEDLINE]
10.

Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pK(a): antibacterial agents with an improved safety profile.

Reck F, Alm RA, Brassil P, Newman JV, Ciaccio P, McNulty J, Barthlow H, Goteti K, Breen J, Comita-Prevoir J, Cronin M, Ehmann DE, Geng B, Godfrey AA, Fisher SL.

J Med Chem. 2012 Aug 9;55(15):6916-33. doi: 10.1021/jm300690s. Epub 2012 Jul 20.

PMID:
22779424
[PubMed - indexed for MEDLINE]
11.

Cleavable-complex formation by wild-type and quinolone-resistant Streptococcus pneumoniae type II topoisomerases mediated by gemifloxacin and other fluoroquinolones.

Yague G, Morris JE, Pan XS, Gould KA, Fisher LM.

Antimicrob Agents Chemother. 2002 Feb;46(2):413-9.

PMID:
11796351
[PubMed - indexed for MEDLINE]
Free PMC Article
12.

Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity.

Surivet JP, Zumbrunn C, Rueedi G, Hubschwerlen C, Bur D, Bruyère T, Locher H, Ritz D, Keck W, Seiler P, Kohl C, Gauvin JC, Mirre A, Kaegi V, Dos Santos M, Gaertner M, Delers J, Enderlin-Paput M, Boehme M.

J Med Chem. 2013 Sep 26;56(18):7396-415. doi: 10.1021/jm400963y. Epub 2013 Sep 11.

PMID:
23968485
[PubMed - indexed for MEDLINE]
13.

Discovery of a novel azaindole class of antibacterial agents targeting the ATPase domains of DNA gyrase and Topoisomerase IV.

Manchester JI, Dussault DD, Rose JA, Boriack-Sjodin PA, Uria-Nickelsen M, Ioannidis G, Bist S, Fleming P, Hull KG.

Bioorg Med Chem Lett. 2012 Aug 1;22(15):5150-6. doi: 10.1016/j.bmcl.2012.05.128. Epub 2012 Jun 19.

PMID:
22814212
[PubMed - indexed for MEDLINE]
14.

Methods to assay inhibitors of DNA gyrase and topoisomerase IV activities.

Fisher LM, Pan XS.

Methods Mol Med. 2008;142:11-23. doi: 10.1007/978-1-59745-246-5_2.

PMID:
18437302
[PubMed - indexed for MEDLINE]
15.

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: development of inhibitors with broad spectrum, Gram-negative antibacterial activity.

Trzoss M, Bensen DC, Li X, Chen Z, Lam T, Zhang J, Creighton CJ, Cunningham ML, Kwan B, Stidham M, Nelson K, Brown-Driver V, Castellano A, Shaw KJ, Lightstone FC, Wong SE, Nguyen TB, Finn J, Tari LW.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1537-43. doi: 10.1016/j.bmcl.2012.11.073. Epub 2012 Dec 8.

PMID:
23294697
[PubMed - indexed for MEDLINE]
16.

Dual-targeting properties of the 3-aminopyrrolidyl quinolones, DC-159a and sitafloxacin, against DNA gyrase and topoisomerase IV: contribution to reducing in vitro emergence of quinolone-resistant Streptococcus pneumoniae.

Okumura R, Hirata T, Onodera Y, Hoshino K, Otani T, Yamamoto T.

J Antimicrob Chemother. 2008 Jul;62(1):98-104. doi: 10.1093/jac/dkn136. Epub 2008 Apr 4.

PMID:
18390884
[PubMed - indexed for MEDLINE]
Free Article
17.

Target specificity of the new fluoroquinolone besifloxacin in Streptococcus pneumoniae, Staphylococcus aureus and Escherichia coli.

Cambau E, Matrat S, Pan XS, Roth Dit Bettoni R, Corbel C, Aubry A, Lascols C, Driot JY, Fisher LM.

J Antimicrob Chemother. 2009 Mar;63(3):443-50. doi: 10.1093/jac/dkn528. Epub 2009 Jan 15.

PMID:
19147516
[PubMed - indexed for MEDLINE]
Free Article
18.

DNA gyrase and topoisomerase IV are dual targets of zabofloxacin in Streptococcus pneumoniae.

Park HS, Jung SJ, Kwak JH, Choi DR, Choi EC.

Int J Antimicrob Agents. 2010 Jul;36(1):97-8. doi: 10.1016/j.ijantimicag.2010.02.022. Epub 2010 Apr 18. No abstract available.

PMID:
20403681
[PubMed - indexed for MEDLINE]
19.

Mechanism of action of the antibiotic NXL101, a novel nonfluoroquinolone inhibitor of bacterial type II topoisomerases.

Black MT, Stachyra T, Platel D, Girard AM, Claudon M, Bruneau JM, Miossec C.

Antimicrob Agents Chemother. 2008 Sep;52(9):3339-49. doi: 10.1128/AAC.00496-08. Epub 2008 Jul 14.

PMID:
18625781
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Quercetin diacylglycoside analogues showing dual inhibition of DNA gyrase and topoisomerase IV as novel antibacterial agents.

Hossion AM, Zamami Y, Kandahary RK, Tsuchiya T, Ogawa W, Iwado A, Sasaki K.

J Med Chem. 2011 Jun 9;54(11):3686-703. doi: 10.1021/jm200010x. Epub 2011 May 13.

PMID:
21534606
[PubMed - indexed for MEDLINE]

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