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Items: 1 to 20 of 133

1.

Pharmacokinetics and metabolism of SL-01, a prodrug of gemcitabine, in rats.

Zhao C, Li Y, Qin Y, Wang R, Li G, Sun C, Qu X, Li W.

Cancer Chemother Pharmacol. 2013 Jun;71(6):1541-50. doi: 10.1007/s00280-013-2153-6. Epub 2013 Apr 6.

PMID:
23564376
2.
3.

Gender-related pharmacokinetics and absolute bioavailability of diosbulbin B in rats determined by ultra-performance liquid chromatography-tandem mass spectrometry.

Yang B, Wang X, Liu W, Zhang Q, Chen K, Ma Y, Wang C, Wang Z.

J Ethnopharmacol. 2013 Oct 7;149(3):810-5. doi: 10.1016/j.jep.2013.08.010. Epub 2013 Aug 14.

PMID:
23954278
4.

Pharmacokinetics of gemcitabine in tumor and non-tumor extracellular fluid of brain: an in vivo assessment in rats employing intracerebral microdialysis.

Apparaju SK, Gudelsky GA, Desai PB.

Cancer Chemother Pharmacol. 2008 Feb;61(2):223-9. Epub 2007 Apr 19.

PMID:
17443325
5.

Etoposide bioavailability after oral administration of the prodrug etoposide phosphate in cancer patients during a phase I study.

Chabot GG, Armand JP, Terret C, de Forni M, Abigerges D, Winograd B, Igwemezie L, Schacter L, Kaul S, Ropers J, Bonnay M.

J Clin Oncol. 1996 Jul;14(7):2020-30.

PMID:
8683232
6.

High sensitive assay employing column switching chromatography to enable simultaneous quantification of an amide prodrug of gemcitabine (LY2334737), gemcitabine, and its metabolite dFdU in human plasma by LC-MS/MS.

Wickremsinhe ER, Lee LB, Schmalz CA, Torchia J, Ruterbories KJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Aug 1;932:117-22. doi: 10.1016/j.jchromb.2013.06.008. Epub 2013 Jun 13.

PMID:
23831704
7.

Pharmacokinetics of four metabolites of DA-125, a new anthracycline antineoplastic agent after single and multiple intravenous administration to rats.

Lee SD, Lee WI, Shim HJ, Lee ED, Kim WB, Yang J, Kim CK, Lee MG.

J Clin Pharm Ther. 1996 Aug;21(4):201-13.

PMID:
8933293
8.

Bioavailability of the amino acid-attached prodrug as a new anti-HIV agent in rats.

Chae KA, Cho HJ, Sung JM, Lee H, Seo DC, Kim JS, Shin HC.

J Vet Sci. 2007 Sep;8(3):263-7.

9.

Intravenous pharmacokinetics, oral bioavailability, dose proportionality and in situ permeability of anti-malarial lumefantrine in rats.

Wahajuddin, Singh SP, Raju KS, Nafis A, Puri SK, Jain GK.

Malar J. 2011 Oct 10;10:293. doi: 10.1186/1475-2875-10-293.

10.

Excretion, metabolism, and pharmacokinetics of CP-945,598, a selective cannabinoid receptor antagonist, in rats, mice, and dogs.

Miao Z, Scott DO, Griffith DA, Day R, Prakash C.

Drug Metab Dispos. 2011 Dec;39(12):2191-208. doi: 10.1124/dmd.111.040360. Epub 2011 Aug 29.

12.

Pulmonary gemcitabine delivery for treating lung cancer: pharmacokinetics and acute lung injury aspects in animals.

Min R, Li T, Du J, Zhang Y, Guo J, Lu WL.

Can J Physiol Pharmacol. 2008 May;86(5):288-98. doi: 10.1139/y08-039.

PMID:
18432290
13.
14.

Pharmacokinetics of mequindox and its metabolites in rats after intravenous and oral administration.

Li G, Yang F, He L, Ding H, Sun N, Liu Y, Liu Y, Shan Q, Li Y, Zeng Z.

Res Vet Sci. 2012 Dec;93(3):1380-6. doi: 10.1016/j.rvsc.2012.02.015. Epub 2012 Mar 28.

PMID:
22459092
15.

Characterization of the metabolism of sibiricaxanthone F and its aglycone in vitro by high performance liquid chromatography coupled with Q-trap mass spectrometry.

Song Y, Yang X, Jiang Y, Tu P.

J Pharm Biomed Anal. 2012 Nov;70:700-7. doi: 10.1016/j.jpba.2012.06.038. Epub 2012 Jul 3.

PMID:
22819207
16.
17.

Modulation of gemcitabine (2',2'-difluoro-2'-deoxycytidine) pharmacokinetics, metabolism, and bioavailability in mice by 3,4,5,6-tetrahydrouridine.

Beumer JH, Eiseman JL, Parise RA, Joseph E, Covey JM, Egorin MJ.

Clin Cancer Res. 2008 Jun 1;14(11):3529-35. doi: 10.1158/1078-0432.CCR-07-4885.

18.

Metabolism of a new P-glycoprotein inhibitor HM-30181 in rats using liquid chromatography/electrospray mass spectrometry.

Paek IB, Ji HY, Kim MS, Lee G, Lee HS.

Rapid Commun Mass Spectrom. 2006;20(9):1457-62.

PMID:
16586459
19.

Plasma pharmacokinetics and oral bioavailability of the 3,4,5,6-tetrahydrouridine (THU) prodrug, triacetyl-THU (taTHU), in mice.

Beumer JH, Eiseman JL, Gilbert JA, Holleran JL, Yellow-Duke AE, Clausen DM, D'Argenio DZ, Ames MM, Hershberger PA, Parise RA, Bai L, Covey JM, Egorin MJ.

Cancer Chemother Pharmacol. 2011 Feb;67(2):421-30. doi: 10.1007/s00280-010-1337-6. Epub 2010 May 5.

20.

Pharmacokinetics of TH-302: a hypoxically activated prodrug of bromo-isophosphoramide mustard in mice, rats, dogs and monkeys.

Jung D, Lin L, Jiao H, Cai X, Duan JX, Matteucci M.

Cancer Chemother Pharmacol. 2012 Mar;69(3):643-54. doi: 10.1007/s00280-011-1741-6. Epub 2011 Oct 1.

PMID:
21964906
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