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House dust mite allergen Der f 2 induces interleukin-13 expression by activating the PI3K/Akt pathway.

Ro EJ, Cha PH, Kim HY, Cho YH, Park JW, Han JS, Choi KY.

Immunol Res. 2013 May;56(1):181-8. doi: 10.1007/s12026-013-8392-0.


The non-proteolytic house dust mite allergen Der p 2 induce NF-kappaB and MAPK dependent activation of bronchial epithelial cells.

Osterlund C, Grönlund H, Polovic N, Sundström S, Gafvelin G, Bucht A.

Clin Exp Allergy. 2009 Aug;39(8):1199-208. doi: 10.1111/j.1365-2222.2009.03284.x. Epub 2009 May 26.


House dust mite allergen Der f 2-induced phospholipase D1 activation is critical for the production of interleukin-13 through activating transcription factor-2 activation in human bronchial epithelial cells.

Park SY, Cho JH, Oh DY, Park JW, Ahn MJ, Han JS, Oh JW.

J Biol Chem. 2009 Jul 24;284(30):20099-110. doi: 10.1074/jbc.M109.010017. Epub 2009 Jun 1.


Block copolymer/DNA vaccination induces a strong allergen-specific local response in a mouse model of house dust mite asthma.

Rolland-Debord C, Lair D, Roussey-Bihouée T, Hassoun D, Evrard J, Cheminant MA, Chesné J, Braza F, Mahay G, Portero V, Sagan C, Pitard B, Magnan A.

PLoS One. 2014 Jan 31;9(1):e85976. doi: 10.1371/journal.pone.0085976. eCollection 2014.


Rhinovirus infection and house dust mite exposure synergize in inducing bronchial epithelial cell interleukin-8 release.

Bossios A, Gourgiotis D, Skevaki CL, Saxoni-Papageorgiou P, Lötvall J, Psarras S, Karpathios T, Constandopoulos AG, Johnston SL, Papadopoulos NG.

Clin Exp Allergy. 2008 Oct;38(10):1615-26. doi: 10.1111/j.1365-2222.2008.03058.x. Epub 2008 Jul 18.


Anti-malarial drug artesunate attenuates experimental allergic asthma via inhibition of the phosphoinositide 3-kinase/Akt pathway.

Cheng C, Ho WE, Goh FY, Guan SP, Kong LR, Lai WQ, Leung BP, Wong WS.

PLoS One. 2011;6(6):e20932. doi: 10.1371/journal.pone.0020932. Epub 2011 Jun 9.


Increase in allergen-specific IgE and ex vivo Th2 responses after a single bronchial challenge with house dust mite in allergic asthmatics.

van de Pol MA, Lutter R, van Ree R, van der Zee JS.

Allergy. 2012 Jan;67(1):67-73. doi: 10.1111/j.1398-9995.2011.02722.x. Epub 2011 Sep 29.


Induction of IL-6 and IL-8 by house dust mite allergen Der p1 in cultured human nasal epithelial cells is associated with PAR/PI3K/NFkappaB signaling.

Shi J, Luo Q, Chen F, Chen D, Xu G, Li H.

ORL J Otorhinolaryngol Relat Spec. 2010;72(5):256-65. doi: 10.1159/000312687. Epub 2010 Aug 21.


Association between mite allergen (Der p 1, Der f 1, Blo t 5) levels and microscopic identification of mites or skin prick test results in asthmatic subjects.

Medeiros M Jr, Figueiredo JP, Almeida MC, Atta AM, Taketomi EA, Silva DA, Terra SA, Amorim WW, Pinho RS, Araujo MI, Carvalho EM.

Int Arch Allergy Immunol. 2002 Nov;129(3):237-41.


Characterization of the house dust mite allergen Der p 21 produced in Pichia pastoris.

Pulsawat P, Theeraapisakkun M, Nony E, Le Mignon M, Jain K, Buaklin A, Wongpiyabovorn J, Ruxrungtham K, Jacquet A.

Protein Expr Purif. 2014 Sep;101:8-13. doi: 10.1016/j.pep.2014.05.001. Epub 2014 May 27.


Thrombin induces NF-kappaB activation and IL-8/CXCL8 expression in lung epithelial cells by a Rac1-dependent PI3K/Akt pathway.

Lin CH, Cheng HW, Ma HP, Wu CH, Hong CY, Chen BC.

J Biol Chem. 2011 Mar 25;286(12):10483-94. doi: 10.1074/jbc.M110.112433. Epub 2011 Jan 25.


Immune reactivity of recombinant group 2 allergens of house dust mite, Dermatophagoides pteronyssinus, and Dermatophagoides farinae.

Jin HS, Yong TS, Park JW, Hong CS, Oh SH.

J Investig Allergol Clin Immunol. 2003;13(1):36-42.


Prevention and treatment of allergic inflammation by an Fcγ-Der f2 fusion protein in a murine model of dust mite-induced asthma.

Lin LH, Zheng P, Yuen JW, Wang J, Zhou J, Kong CQ, Peng X, Li J, Li L.

Immunol Res. 2012 Jun;52(3):276-83. doi: 10.1007/s12026-012-8339-x.


Epithelial NF-κB orchestrates house dust mite-induced airway inflammation, hyperresponsiveness, and fibrotic remodeling.

Tully JE, Hoffman SM, Lahue KG, Nolin JD, Anathy V, Lundblad LK, Daphtary N, Aliyeva M, Black KE, Dixon AE, Poynter ME, Irvin CG, Janssen-Heininger YM.

J Immunol. 2013 Dec 15;191(12):5811-21. doi: 10.4049/jimmunol.1301329. Epub 2013 Nov 13.


The house dust mite allergen Der p 1, unlike Der p 3, stimulates the expression of interleukin-8 in human airway epithelial cells via a proteinase-activated receptor-2-independent mechanism.

Adam E, Hansen KK, Astudillo Fernandez O, Coulon L, Bex F, Duhant X, Jaumotte E, Hollenberg MD, Jacquet A.

J Biol Chem. 2006 Mar 17;281(11):6910-23. Epub 2005 Nov 17. Erratum in: J Biol Chem. 2007 Feb 16;282(7):5100. Astudillo, Olaya Fernandez [corrected to Astudillo Fernandez, Olaya].


Der p, IL-4, and TGF-beta cooperatively induce EGFR-dependent TARC expression in airway epithelium.

Heijink IH, Marcel Kies P, van Oosterhout AJ, Postma DS, Kauffman HF, Vellenga E.

Am J Respir Cell Mol Biol. 2007 Mar;36(3):351-9. Epub 2006 Oct 5.


IL-13 dampens human airway epithelial innate immunity through induction of IL-1 receptor-associated kinase M.

Wu Q, Jiang D, Smith S, Thaikoottathil J, Martin RJ, Bowler RP, Chu HW.

J Allergy Clin Immunol. 2012 Mar;129(3):825-833.e2. doi: 10.1016/j.jaci.2011.10.043. Epub 2011 Dec 9.

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