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Results: 1 to 20 of 98

1.

Simvastatin-induced compartmentalisation of doxorubicin sharpens up nuclear topoisomerase II inhibition in human rhabdomyosarcoma cells.

Werner M, Atil B, Sieczkowski E, Chiba P, Hohenegger M.

Naunyn Schmiedebergs Arch Pharmacol. 2013 Jul;386(7):605-17. doi: 10.1007/s00210-013-0859-y. Epub 2013 Apr 7.

PMID:
23564041
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Double impact on p-glycoprotein by statins enhances doxorubicin cytotoxicity in human neuroblastoma cells.

Sieczkowski E, Lehner C, Ambros PF, Hohenegger M.

Int J Cancer. 2010 May 1;126(9):2025-35. doi: 10.1002/ijc.24885.

PMID:
19739078
[PubMed - indexed for MEDLINE]
3.

Mutual amplification of apoptosis by statin-induced mitochondrial stress and doxorubicin toxicity in human rhabdomyosarcoma cells.

Werner M, Sacher J, Hohenegger M.

Br J Pharmacol. 2004 Nov;143(6):715-24. Epub 2004 Aug 2.

PMID:
15289292
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

The association of statins plus LDL receptor-targeted liposome-encapsulated doxorubicin increases in vitro drug delivery across blood-brain barrier cells.

Pinzón-Daza M, Garzón R, Couraud P, Romero Ia, Weksler B, Ghigo D, Bosia A, Riganti C.

Br J Pharmacol. 2012 Dec;167(7):1431-47. doi: 10.1111/j.1476-5381.2012.02103.x.

PMID:
22788770
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Effects of HMG-CoA reductase inhibitors on the pharmacokinetics of losartan and its main metabolite EXP-3174 in rats: possible role of CYP3A4 and P-gp inhibition by HMG-CoA reductase inhibitors.

Yang SH, Choi JS, Choi DH.

Pharmacology. 2011;88(1-2):1-9. doi: 10.1159/000328773. Epub 2011 Jun 25.

PMID:
21709429
[PubMed - indexed for MEDLINE]
6.

HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway.

Qi XF, Zheng L, Lee KJ, Kim DH, Kim CS, Cai DQ, Wu Z, Qin JW, Yu YH, Kim SK.

Cell Death Dis. 2013 Feb 28;4:e518. doi: 10.1038/cddis.2013.44.

PMID:
23449454
[PubMed - indexed for MEDLINE]
Free PMC Article
7.
8.

Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma.

Riganti C, Orecchia S, Pescarmona G, Betta PG, Ghigo D, Bosia A.

Int J Cancer. 2006 Jul 1;119(1):17-27.

PMID:
16450390
[PubMed - indexed for MEDLINE]
9.

[Inhibition of ABC-transporter(s)' function in non-small cell lung cancer cells by platinum drugs].

Bogush TA, Konukhova AV, Ravcheeva AB, Zabotina TN, Kadagidze ZG, Bogush EA, Komov DV, Polotskiĭ BE, Laktionov KK, Davydov MI.

Antibiot Khimioter. 2003;48(10):11-5. Russian.

PMID:
15004974
[PubMed - indexed for MEDLINE]
10.

Simvastatin inhibits human saphenous vein neointima formation via inhibition of smooth muscle cell proliferation and migration.

Porter KE, Naik J, Turner NA, Dickinson T, Thompson MM, London NJ.

J Vasc Surg. 2002 Jul;36(1):150-7.

PMID:
12096273
[PubMed - indexed for MEDLINE]
Free Article
11.

Topoisomerase II{alpha}-dependent and -independent apoptotic effects of dexrazoxane and doxorubicin.

Yan T, Deng S, Metzger A, Gödtel-Armbrust U, Porter AC, Wojnowski L.

Mol Cancer Ther. 2009 May;8(5):1075-85. doi: 10.1158/1535-7163.MCT-09-0139. Epub 2009 May 5.

PMID:
19417146
[PubMed - indexed for MEDLINE]
Free Article
12.

HT1080/DR4: a P-glycoprotein-negative human fibrosarcoma cell line exhibiting resistance to topoisomerase II-reactive drugs despite the presence of a drug-sensitive topoisomerase II.

Zwelling LA, Slovak ML, Doroshow JH, Hinds M, Chan D, Parker E, Mayes J, Sie KL, Meltzer PS, Trent JM.

J Natl Cancer Inst. 1990 Oct 3;82(19):1553-61.

PMID:
1976136
[PubMed - indexed for MEDLINE]
13.

Lovastatin protects human endothelial cells from the genotoxic and cytotoxic effects of the anticancer drugs doxorubicin and etoposide.

Damrot J, Nübel T, Epe B, Roos WP, Kaina B, Fritz G.

Br J Pharmacol. 2006 Dec;149(8):988-97. Epub 2006 Nov 6.

PMID:
17088865
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation.

Blanco-Colio LM, Villa A, Ortego M, Hernández-Presa MA, Pascual A, Plaza JJ, Egido J.

Atherosclerosis. 2002 Mar;161(1):17-26.

PMID:
11882313
[PubMed - indexed for MEDLINE]
15.

Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1.

Chen C, Mireles RJ, Campbell SD, Lin J, Mills JB, Xu JJ, Smolarek TA.

Drug Metab Dispos. 2005 Apr;33(4):537-46. Epub 2004 Dec 22.

PMID:
15616150
[PubMed - indexed for MEDLINE]
Free Article
17.

Rac1 protein signaling is required for DNA damage response stimulated by topoisomerase II poisons.

Huelsenbeck SC, Schorr A, Roos WP, Huelsenbeck J, Henninger C, Kaina B, Fritz G.

J Biol Chem. 2012 Nov 9;287(46):38590-9. doi: 10.1074/jbc.M112.377903. Epub 2012 Sep 25.

PMID:
23012366
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Simvastatin reduces insulin-like growth factor-1 signaling in differentiating C2C12 mouse myoblast cells in an HMG-CoA reductase inhibition-independent manner.

Ogura T, Tanaka Y, Nakata T, Namikawa T, Kataoka H, Ohtsubo Y.

J Toxicol Sci. 2007 Feb;32(1):57-67.

PMID:
17327694
[PubMed - indexed for MEDLINE]
Free Article
19.

Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells.

Takeda I, Maruya S, Shirasaki T, Mizukami H, Takahata T, Myers JN, Kakehata S, Yagihashi S, Shinkawa H.

Cancer Sci. 2007 Jun;98(6):890-9. Epub 2007 Apr 12.

PMID:
17428261
[PubMed - indexed for MEDLINE]
20.

Pravastatin inhibited the cholesterol synthesis in human hepatoma cell line Hep G2 less than simvastatin and lovastatin, which is reflected in the upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and squalene synthase.

Cohen LH, van Vliet A, Roodenburg L, Jansen LM, Griffioen M.

Biochem Pharmacol. 1993 Jun 9;45(11):2203-8. Erratum in: Biochem Pharmacol 1993 Sep 14;46(6):1101.

PMID:
8517861
[PubMed - indexed for MEDLINE]

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