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In-silico designing of a potent analogue against HIV-1 Nef protein and protease by predicting its interaction network with host cell proteins.

Pal S, Mishra M, Sudhakar DR, Siddiqui MH.

J Pharm Bioallied Sci. 2013 Jan;5(1):66-73. doi: 10.4103/0975-7406.106572.


A dileucine motif in HIV-1 Nef acts as an internalization signal for CD4 downregulation and binds the AP-1 clathrin adaptor.

Bresnahan PA, Yonemoto W, Ferrell S, Williams-Herman D, Geleziunas R, Greene WC.

Curr Biol. 1998 Nov 5;8(22):1235-8.


Nef: "necessary and enforcing factor" in HIV infection.

Joseph AM, Kumar M, Mitra D.

Curr HIV Res. 2005 Jan;3(1):87-94. Review.


Co-localization of HIV-1 Nef with the AP-2 adaptor protein complex correlates with Nef-induced CD4 down-regulation.

Greenberg ME, Bronson S, Lock M, Neumann M, Pavlakis GN, Skowronski J.

EMBO J. 1997 Dec 1;16(23):6964-76.


HIV-1 Nef control of cell signalling molecules: multiple strategies to promote virus replication.

Greenway AL, Holloway G, McPhee DA, Ellis P, Cornall A, Lidman M.

J Biosci. 2003 Apr;28(3):323-35. Review.


Interactions of processed Nef (58-206) with virion proteins of HIV type 1.

Ciuffi A, Munoz M, Bleiber G, Favre M, Stutz F, Telenti A, Meylan PR.

AIDS Res Hum Retroviruses. 2004 Apr;20(4):399-407.


Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS.

Carl S, Greenough TC, Krumbiegel M, Greenberg M, Skowronski J, Sullivan JL, Kirchhoff F.

J Virol. 2001 Apr;75(8):3657-65.


Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation.

Liu LX, Margottin F, Le Gall S, Schwartz O, Selig L, Benarous R, Benichou S.

J Biol Chem. 1997 May 23;272(21):13779-85.


The human thioesterase II protein binds to a site on HIV-1 Nef critical for CD4 down-regulation.

Cohen GB, Rangan VS, Chen BK, Smith S, Baltimore D.

J Biol Chem. 2000 Jul 28;275(30):23097-105.


Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication.

Arga├▒araz ER, Schindler M, Kirchhoff F, Cortes MJ, Lama J.

J Biol Chem. 2003 Sep 5;278(36):33912-9. Epub 2003 Jun 19.


Contribution of antibody response to recombinant HIV-1 gene-encoded products nef, rev, tat, and protease in predicting development of AIDS in HIV-1-infected individuals.

Reiss P, de Wolf F, Kuiken CL, de Ronde A, Dekker J, Boucher CA, Debouck C, Lange JM, Goudsmit J.

J Acquir Immune Defic Syndr. 1991;4(2):165-72.


HLA-A2 down-regulation on primary human macrophages infected with an M-tropic EGFP-tagged HIV-1 reporter virus.

Brown A, Gartner S, Kawano T, Benoit N, Cheng-Mayer C.

J Leukoc Biol. 2005 Sep;78(3):675-85. Epub 2005 Jul 6.


Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef.

Keppler OT, Allespach I, Sch├╝ller L, Fenard D, Greene WC, Fackler OT.

J Virol. 2005 Feb;79(3):1655-65.


Hck SH3 domain-dependent abrogation of Nef-induced class 1 MHC down-regulation.

Chang AH, O'Shaughnessy MV, Jirik FR.

Eur J Immunol. 2001 Aug;31(8):2382-7.


Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor.

Chaudhuri R, Lindwasser OW, Smith WJ, Hurley JH, Bonifacino JS.

J Virol. 2007 Apr;81(8):3877-90. Epub 2007 Jan 31.

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