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Results: 1 to 20 of 102

1.

An antiapoptotic Bcl-2 family protein index predicts the response of leukaemic cells to the pan-Bcl-2 inhibitor S1.

Zhang Z, Liu Y, Song T, Xue Z, Shen X, Liang F, Zhao Y, Li Z, Sheng H.

Br J Cancer. 2013 May 14;108(9):1870-8. doi: 10.1038/bjc.2013.152. Epub 2013 Apr 4.

PMID:
23558901
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Pan-BH3 mimetic S1 exhibits broad-spectrum antitumour effects by cooperation between Bax and Bak.

Song T, Xue Z, Zhang Z, Shen X, Li X.

Basic Clin Pharmacol Toxicol. 2013 Sep;113(3):145-51. doi: 10.1111/bcpt.12074. Epub 2013 May 20.

PMID:
23557083
[PubMed - indexed for MEDLINE]
3.

A novel BH3 mimetic S1 potently induces Bax/Bak-dependent apoptosis by targeting both Bcl-2 and Mcl-1.

Zhang Z, Song T, Zhang T, Gao J, Wu G, An L, Du G.

Int J Cancer. 2011 Apr 1;128(7):1724-35. doi: 10.1002/ijc.25484. Epub 2010 May 25.

PMID:
20503275
[PubMed - indexed for MEDLINE]
4.

S1, a novel pan-BH3 mimetic, induces apoptosis in Mcl-1-overexpressing cells through Bak.

Song T, Chang X, Zhang Z, Liu Y, Shen X.

J Pharmacol Sci. 2012;119(4):330-40. Epub 2012 Jul 12.

PMID:
22814102
[PubMed - indexed for MEDLINE]
Free Article
5.

CDK inhibitors upregulate BH3-only proteins to sensitize human myeloma cells to BH3 mimetic therapies.

Chen S, Dai Y, Pei XY, Myers J, Wang L, Kramer LB, Garnett M, Schwartz DM, Su F, Simmons GL, Richey JD, Larsen DG, Dent P, Orlowski RZ, Grant S.

Cancer Res. 2012 Aug 15;72(16):4225-37. doi: 10.1158/0008-5472.CAN-12-1118. Epub 2012 Jun 12.

PMID:
22693249
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner.

Kazi A, Sun J, Doi K, Sung SS, Takahashi Y, Yin H, Rodriguez JM, Becerril J, Berndt N, Hamilton AD, Wang HG, Sebti SM.

J Biol Chem. 2011 Mar 18;286(11):9382-92. doi: 10.1074/jbc.M110.203638. Epub 2010 Dec 9.

PMID:
21148306
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.

Rahmani M, Aust MM, Attkisson E, Williams DC Jr, Ferreira-Gonzalez A, Grant S.

Cancer Res. 2013 Feb 15;73(4):1340-51. doi: 10.1158/0008-5472.CAN-12-1365. Epub 2012 Dec 12.

PMID:
23243017
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Mechanisms of anti-leukemic activity of the Bcl-2 homology domain-3 mimetic S1.

Liu Y, Li Z, Song T, Xue Z, Zhang Z.

Biomed Pharmacother. 2013 Sep;67(7):583-91. doi: 10.1016/j.biopha.2013.04.010. Epub 2013 May 3.

PMID:
23706691
[PubMed - indexed for MEDLINE]
9.

The novel BH3 α-helix mimetic JY-1-106 induces apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak.

Cao X, Yap JL, Newell-Rogers MK, Peddaboina C, Jiang W, Papaconstantinou HT, Jupitor D, Rai A, Jung KY, Tubin RP, Yu W, Vanommeslaeghe K, Wilder PT, MacKerell AD Jr, Fletcher S, Smythe RW.

Mol Cancer. 2013 May 16;12(1):42. doi: 10.1186/1476-4598-12-42.

PMID:
23680104
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Optimization and validation of mitochondria-based functional assay as a useful tool to identify BH3-like molecules selectively targeting anti-apoptotic Bcl-2 proteins.

Long J, Liu L, Nikolovska-Coleska Z, Shangary S, Yi H, Wang S, Wang S.

BMC Biotechnol. 2013 May 24;13:45. doi: 10.1186/1472-6750-13-45.

PMID:
23705845
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Mcl-1 as a buffer for proapoptotic Bcl-2 family members during TRAIL-induced apoptosis: a mechanistic basis for sorafenib (Bay 43-9006)-induced TRAIL sensitization.

Meng XW, Lee SH, Dai H, Loegering D, Yu C, Flatten K, Schneider P, Dai NT, Kumar SK, Smith BD, Karp JE, Adjei AA, Kaufmann SH.

J Biol Chem. 2007 Oct 12;282(41):29831-46. Epub 2007 Aug 13.

PMID:
17698840
[PubMed - indexed for MEDLINE]
Free Article
12.

3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1.

Song T, Li X, Chang X, Liang X, Zhao Y, Wu G, Xie S, Su P, Wu Z, Feng Y, Zhang Z.

Bioorg Med Chem. 2013 Jan 1;21(1):11-20. doi: 10.1016/j.bmc.2012.11.008. Epub 2012 Nov 21. Erratum in: Bioorg Med Chem. 2014 Jan 1;22(1):663-4.

PMID:
23206987
[PubMed - indexed for MEDLINE]
13.

BCL-2 phosphorylation modulates sensitivity to the BH3 mimetic GX15-070 (Obatoclax) and reduces its synergistic interaction with bortezomib in chronic lymphocytic leukemia cells.

Pérez-Galán P, Roué G, López-Guerra M, Nguyen M, Villamor N, Montserrat E, Shore GC, Campo E, Colomer D.

Leukemia. 2008 Sep;22(9):1712-20. doi: 10.1038/leu.2008.175. Epub 2008 Jul 3.

PMID:
18596739
[PubMed - indexed for MEDLINE]
14.

S1 kills MCF-7/ADR cells more than MCF-7 cells: A protective mechanism of endoplasmic reticulum stress.

Song T, Liang F, Zhang Z, Liu Y, Sheng H, Xie M.

Biomed Pharmacother. 2013 Oct;67(8):731-6. doi: 10.1016/j.biopha.2013.03.015. Epub 2013 Apr 2.

PMID:
23602052
[PubMed - indexed for MEDLINE]
15.

The proteasome inhibitor MG132 potentiates TRAIL receptor agonist-induced apoptosis by stabilizing tBid and Bik in human head and neck squamous cell carcinoma cells.

Sung ES, Park KJ, Choi HJ, Kim CH, Kim YS.

Exp Cell Res. 2012 Aug 1;318(13):1564-76. doi: 10.1016/j.yexcr.2012.04.003. Epub 2012 Apr 10.

PMID:
22513214
[PubMed - indexed for MEDLINE]
16.

Inhibition of Bcl-2 antiapoptotic members by obatoclax potently enhances sorafenib-induced apoptosis in human myeloid leukemia cells through a Bim-dependent process.

Rahmani M, Aust MM, Attkisson E, Williams DC Jr, Ferreira-Gonzalez A, Grant S.

Blood. 2012 Jun 21;119(25):6089-98. doi: 10.1182/blood-2011-09-378141. Epub 2012 Mar 23.

PMID:
22446485
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

BH3 domains other than Bim and Bid can directly activate Bax/Bak.

Du H, Wolf J, Schafer B, Moldoveanu T, Chipuk JE, Kuwana T.

J Biol Chem. 2011 Jan 7;286(1):491-501. doi: 10.1074/jbc.M110.167148. Epub 2010 Nov 1.

PMID:
21041309
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Bcl-2 is a better ABT-737 target than Bcl-xL or Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B.

Rooswinkel RW, van de Kooij B, Verheij M, Borst J.

Cell Death Dis. 2012 Aug 9;3:e366. doi: 10.1038/cddis.2012.109.

PMID:
22875003
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Mcl-1 Phosphorylation defines ABT-737 resistance that can be overcome by increased NOXA expression in leukemic B cells.

Mazumder S, Choudhary GS, Al-Harbi S, Almasan A.

Cancer Res. 2012 Jun 15;72(12):3069-79. doi: 10.1158/0008-5472.CAN-11-4106. Epub 2012 Apr 23.

PMID:
22525702
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

A novel Bim-BH3-derived Bcl-XL inhibitor: biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activity.

Ponassi R, Biasotti B, Tomati V, Bruno S, Poggi A, Malacarne D, Cimoli G, Salis A, Pozzi S, Miglino M, Damonte G, Cozzini P, Spyrakis F, Campanini B, Bagnasco L, Castagnino N, Tortolina L, Mumot A, Frassoni F, Daga A, Cilli M, Piccardi F, Monfardini I, Perugini M, Zoppoli G, D'Arrigo C, Pesenti R, Parodi S.

Cell Cycle. 2008 Oct;7(20):3211-24. Epub 2008 Oct 20. Erratum in: Cell Cycle. 2012 Oct 1;11(19):3703. Spyraki, Francesca [corrected to Spyrakis, Francesca].

PMID:
18843207
[PubMed - indexed for MEDLINE]
Free Article

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