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Results: 1 to 20 of 121

1.

Kinetic analysis of human and canine P-glycoprotein-mediated drug transport in MDR1-MDCK cell model: approaches to reduce false-negative substrate classification.

Li J, Wang Y, Hidalgo IJ.

J Pharm Sci. 2013 Sep;102(9):3436-46. doi: 10.1002/jps.23523. Epub 2013 Apr 5.

PMID:
23558561
[PubMed - indexed for MEDLINE]
2.

Establishment of optimized MDCK cell lines for reliable efflux transport studies.

Gartzke D, Fricker G.

J Pharm Sci. 2014 Apr;103(4):1298-304. doi: 10.1002/jps.23901. Epub 2014 Feb 15.

PMID:
24532159
[PubMed - indexed for MEDLINE]
3.

Differences in the expression of endogenous efflux transporters in MDR1-transfected versus wildtype cell lines affect P-glycoprotein mediated drug transport.

Kuteykin-Teplyakov K, Luna-Tortós C, Ambroziak K, Löscher W.

Br J Pharmacol. 2010 Jul;160(6):1453-63. doi: 10.1111/j.1476-5381.2010.00801.x.

PMID:
20590635
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Functional assessment of multiple P-glycoprotein (P-gp) probe substrates: influence of cell line and modulator concentration on P-gp activity.

Taub ME, Podila L, Ely D, Almeida I.

Drug Metab Dispos. 2005 Nov;33(11):1679-87. Epub 2005 Aug 10.

PMID:
16093365
[PubMed - indexed for MEDLINE]
Free Article
6.

Transepithelial transport of drugs by the multidrug transporter in cultured Madin-Darby canine kidney cell epithelia.

Horio M, Chin KV, Currier SJ, Goldenberg S, Williams C, Pastan I, Gottesman MM, Handler J.

J Biol Chem. 1989 Sep 5;264(25):14880-4.

PMID:
2570070
[PubMed - indexed for MEDLINE]
Free Article
7.

Transfected MDCK cell line with enhanced expression of CYP3A4 and P-glycoprotein as a model to study their role in drug transport and metabolism.

Kwatra D, Budda B, Vadlapudi AD, Vadlapatla RK, Pal D, Mitra AK.

Mol Pharm. 2012 Jul 2;9(7):1877-86. doi: 10.1021/mp200487h. Epub 2012 Jun 19.

PMID:
22676443
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Evaluation of P-glycoprotein-mediated renal drug interactions in an MDR1-MDCK model.

Karyekar CS, Eddington ND, Garimella TS, Gubbins PO, Dowling TC.

Pharmacotherapy. 2003 Apr;23(4):436-42.

PMID:
12680473
[PubMed - indexed for MEDLINE]
9.

Vectorial transport of the plant alkaloid berberine by double-transfected cells expressing the human organic cation transporter 1 (OCT1, SLC22A1) and the efflux pump MDR1 P-glycoprotein (ABCB1).

Nies AT, Herrmann E, Brom M, Keppler D.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Feb;376(6):449-61. Epub 2007 Dec 19.

PMID:
18157518
[PubMed - indexed for MEDLINE]
11.

Endogenous drug transporters in in vitro and in vivo models for the prediction of drug disposition in man.

Goh LB, Spears KJ, Yao D, Ayrton A, Morgan P, Roland Wolf C, Friedberg T.

Biochem Pharmacol. 2002 Dec 1;64(11):1569-78.

PMID:
12429346
[PubMed - indexed for MEDLINE]
12.

Models to predict unbound intracellular drug concentrations in the presence of transporters.

Korzekwa KR, Nagar S, Tucker J, Weiskircher EA, Bhoopathy S, Hidalgo IJ.

Drug Metab Dispos. 2012 May;40(5):865-76. doi: 10.1124/dmd.111.044289. Epub 2012 Jan 25.

PMID:
22279052
[PubMed - indexed for MEDLINE]
Free Article
13.

Inhibition of P-glycoprotein transport function and reversion of MDR1 multidrug resistance by cnidiadin.

Barthomeuf C, Grassi J, Demeule M, Fournier C, Boivin D, Béliveau R.

Cancer Chemother Pharmacol. 2005 Aug;56(2):173-81. Epub 2005 Apr 12.

PMID:
15824923
[PubMed - indexed for MEDLINE]
14.

[Advances in the MDCK-MDR1 cell model and its applications to screen drug permeability].

Liu Y, Zeng S.

Yao Xue Xue Bao. 2008 Jun;43(6):559-64. Review. Chinese.

PMID:
18822955
[PubMed - indexed for MEDLINE]
15.

In vitro characterization of ABC transporters involved in the absorption and distribution of liensinine and its analogs.

Yu L, Shen Q, Zhou Q, Jiang H, Bi H, Huang M, Zhou H, Zeng S.

J Ethnopharmacol. 2013 Nov 25;150(2):485-91. doi: 10.1016/j.jep.2013.08.061. Epub 2013 Sep 12.

PMID:
24036064
[PubMed - indexed for MEDLINE]
16.

Assessment of P-glycoprotein substrate and inhibition potential of test compounds in MDR1-transfected MDCK cells.

C L Lam K, Rajaraman G.

Curr Protoc Pharmacol. 2012 Sep;Chapter 7:Unit7.13. doi: 10.1002/0471141755.ph0713s58.

PMID:
22948850
[PubMed - indexed for MEDLINE]
17.

Cloning and heterologous expression of the ovine (Ovis aries) P-glycoprotein (Mdr1) in Madin-Darby canine kidney (MDCK) cells.

Zahner D, Alber J, Petzinger E.

J Vet Pharmacol Ther. 2010 Jun 1;33(3):304-11. doi: 10.1111/j.1365-2885.2009.01141.x.

PMID:
20557448
[PubMed - indexed for MEDLINE]
18.

Are MDCK cells transfected with the human MDR1 gene a good model of the human intestinal mucosa?

Tang F, Horie K, Borchardt RT.

Pharm Res. 2002 Jun;19(6):765-72.

PMID:
12134945
[PubMed - indexed for MEDLINE]
19.

Digoxin net secretory transport in bronchial epithelial cell layers is not exclusively mediated by P-glycoprotein/MDR1.

Hutter V, Chau DY, Hilgendorf C, Brown A, Cooper A, Zann V, Pritchard DI, Bosquillon C.

Eur J Pharm Biopharm. 2014 Jan;86(1):74-82. doi: 10.1016/j.ejpb.2013.06.010. Epub 2013 Jun 28.

PMID:
23816640
[PubMed - indexed for MEDLINE]
Free Article
20.

Compartmental models for apical efflux by P-glycoprotein--part 1: evaluation of model complexity.

Nagar S, Tucker J, Weiskircher EA, Bhoopathy S, Hidalgo IJ, Korzekwa K.

Pharm Res. 2014 Feb;31(2):347-59. doi: 10.1007/s11095-013-1164-7. Epub 2013 Sep 10.

PMID:
24019023
[PubMed - indexed for MEDLINE]

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