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Results: 1 to 20 of 128

Similar articles for PubMed (Select 23545530)

1.

Kinetic and structural analysis for potent antifolate inhibition of Pneumocystis jirovecii, Pneumocystis carinii, and human dihydrofolate reductases and their active-site variants.

Cody V, Pace J, Queener SF, Adair OO, Gangjee A.

Antimicrob Agents Chemother. 2013 Jun;57(6):2669-77. doi: 10.1128/AAC.00172-13. Epub 2013 Apr 1.

2.

Correlations of inhibitor kinetics for Pneumocystis jirovecii and human dihydrofolate reductase with structural data for human active site mutant enzyme complexes.

Cody V, Pace J, Makin J, Piraino J, Queener SF, Rosowsky A.

Biochemistry. 2009 Mar 3;48(8):1702-11. doi: 10.1021/bi801960h.

3.

Crystallographic analysis reveals a novel second binding site for trimethoprim in active site double mutants of human dihydrofolate reductase.

Cody V, Pace J, Piraino J, Queener SF.

J Struct Biol. 2011 Oct;176(1):52-9. doi: 10.1016/j.jsb.2011.06.001. Epub 2011 Jun 13.

4.

New 2,4-diamino-5-(2',5'-substituted benzyl)pyrimidines as potential drugs against opportunistic infections of AIDS and other immune disorders. Synthesis and species-dependent antifolate activity.

Rosowsky A, Forsch RA, Sibley CH, Inderlied CB, Queener SF.

J Med Chem. 2004 Mar 11;47(6):1475-86. Erratum in: J Med Chem. 2004 Jul 1;47(14):3705.

PMID:
14998335
6.

Design, synthesis, and molecular modeling of novel pyrido[2,3-d]pyrimidine analogues as antifolates; application of Buchwald-Hartwig aminations of heterocycles.

Gangjee A, Namjoshi OA, Raghavan S, Queener SF, Kisliuk RL, Cody V.

J Med Chem. 2013 Jun 13;56(11):4422-41. doi: 10.1021/jm400086g. Epub 2013 May 21.

8.

Structural analysis of Pneumocystis carinii and human DHFR complexes with NADPH and a series of five potent 6-[5'-(ω-carboxyalkoxy)benzyl]pyrido[2,3-d]pyrimidine derivatives.

Cody V, Pace J.

Acta Crystallogr D Biol Crystallogr. 2011 Jan;67(Pt 1):1-7. doi: 10.1107/S0907444910041004. Epub 2010 Dec 16.

9.

Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry.

Cody V, Luft JR, Pangborn W, Gangjee A, Queener SF.

Acta Crystallogr D Biol Crystallogr. 2004 Apr;60(Pt 4):646-55. Epub 2004 Mar 23.

PMID:
15039552
11.

Dihydrofolate reductase from the pathogenic fungus Pneumocystis carinii: catalytic properties and interaction with antifolates.

Margosiak SA, Appleman JR, Santi DV, Blakley RL.

Arch Biochem Biophys. 1993 Sep;305(2):499-508.

PMID:
8373187
12.
13.

2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases.

Gangjee A, Vasudevan A, Queener SF, Kisliuk RL.

J Med Chem. 1996 Mar 29;39(7):1438-46. Erratum in: J Med Chem 1996 Aug 2;39(16):3228.

PMID:
8691474
15.

Preliminary in vitro studies on two potent, water-soluble trimethoprim analogues with exceptional species selectivity against dihydrofolate reductase from Pneumocystis carinii and Mycobacterium avium.

Forsch RA, Queener SF, Rosowsky A.

Bioorg Med Chem Lett. 2004 Apr 5;14(7):1811-5. Erratum in: Bioorg Med Chem Lett. 2004 May 17;14(10):2693.

PMID:
15026078
17.
19.
20.

Structural studies on bioactive compounds. 30. Crystal structure and molecular modeling studies on the Pneumocystis carinii dihydrofolate reductase cofactor complex with TAB, a highly selective antifolate.

Cody V, Chan D, Galitsky N, Rak D, Luft JR, Pangborn W, Queener SF, Laughton CA, Stevens MF.

Biochemistry. 2000 Apr 4;39(13):3556-64.

PMID:
10736154
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