Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 125

1.

HtrA2/Omi deficiency causes damage and mutation of mitochondrial DNA.

Goo HG, Jung MK, Han SS, Rhim H, Kang S.

Biochim Biophys Acta. 2013 Aug;1833(8):1866-75. doi: 10.1016/j.bbamcr.2013.03.016. Epub 2013 Mar 28.

PMID:
23542127
[PubMed - indexed for MEDLINE]
Free Article
2.

A novel role for the mitochondrial HTRA2/OMI protease in aging.

Kang S, Fernandes-Alnemri T, Alnemri ES.

Autophagy. 2013 Mar;9(3):420-1. doi: 10.4161/auto.22920. Epub 2012 Dec 14.

PMID:
23242108
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Inactivation of Omi/HtrA2 protease leads to the deregulation of mitochondrial Mulan E3 ubiquitin ligase and increased mitophagy.

Cilenti L, Ambivero CT, Ward N, Alnemri ES, Germain D, Zervos AS.

Biochim Biophys Acta. 2014 Jul;1843(7):1295-307. doi: 10.1016/j.bbamcr.2014.03.027. Epub 2014 Apr 5.

PMID:
24709290
[PubMed - indexed for MEDLINE]
4.

Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1.

Kieper N, Holmström KM, Ciceri D, Fiesel FC, Wolburg H, Ziviani E, Whitworth AJ, Martins LM, Kahle PJ, Krüger R.

Exp Cell Res. 2010 Apr 15;316(7):1213-24. doi: 10.1016/j.yexcr.2010.01.005. Epub 2010 Jan 11.

PMID:
20064504
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Loss of HtrA2/Omi activity in non-neuronal tissues of adult mice causes premature aging.

Kang S, Louboutin JP, Datta P, Landel CP, Martinez D, Zervos AS, Strayer DS, Fernandes-Alnemri T, Alnemri ES.

Cell Death Differ. 2013 Feb;20(2):259-69. doi: 10.1038/cdd.2012.117. Epub 2012 Sep 14.

PMID:
22976834
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Enhanced HtrA2/Omi expression in oxidative injury to retinal pigment epithelial cells and murine models of neurodegeneration.

Ding X, Patel M, Shen D, Herzlich AA, Cao X, Villasmil R, Klupsch K, Tuo J, Downward J, Chan CC.

Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4957-66. doi: 10.1167/iovs.09-3381. Epub 2009 May 14.

PMID:
19443712
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Akt attenuation of the serine protease activity of HtrA2/Omi through phosphorylation of serine 212.

Yang L, Sun M, Sun XM, Cheng GZ, Nicosia SV, Cheng JQ.

J Biol Chem. 2007 Apr 13;282(15):10981-7. Epub 2007 Feb 20.

PMID:
17311912
[PubMed - indexed for MEDLINE]
Free Article
8.

HtrA2/Omi influences the stability of LON protease 1 and prohibitin, proteins involved in mitochondrial homeostasis.

Goo HG, Rhim H, Kang S.

Exp Cell Res. 2014 Nov 1;328(2):456-65. doi: 10.1016/j.yexcr.2014.07.032. Epub 2014 Aug 2.

PMID:
25094062
[PubMed - in process]
9.

HtrA2 deficiency causes mitochondrial uncoupling through the F₁F₀-ATP synthase and consequent ATP depletion.

Plun-Favreau H, Burchell VS, Holmström KM, Yao Z, Deas E, Cain K, Fedele V, Moisoi N, Campanella M, Miguel Martins L, Wood NW, Gourine AV, Abramov AY.

Cell Death Dis. 2012 Jun 28;3:e335. doi: 10.1038/cddis.2012.77.

PMID:
22739987
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Neuroprotective role of the Reaper-related serine protease HtrA2/Omi revealed by targeted deletion in mice.

Martins LM, Morrison A, Klupsch K, Fedele V, Moisoi N, Teismann P, Abuin A, Grau E, Geppert M, Livi GP, Creasy CL, Martin A, Hargreaves I, Heales SJ, Okada H, Brandner S, Schulz JB, Mak T, Downward J.

Mol Cell Biol. 2004 Nov;24(22):9848-62.

PMID:
15509788
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases.

Li B, Hu Q, Wang H, Man N, Ren H, Wen L, Nukina N, Fei E, Wang G.

Cell Death Differ. 2010 Nov;17(11):1773-84. doi: 10.1038/cdd.2010.55. Epub 2010 May 14.

PMID:
20467442
[PubMed - indexed for MEDLINE]
Free Article
12.

Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways.

Suzuki Y, Takahashi-Niki K, Akagi T, Hashikawa T, Takahashi R.

Cell Death Differ. 2004 Feb;11(2):208-16.

PMID:
14605674
[PubMed - indexed for MEDLINE]
Free Article
13.

The induction of reactive oxygen species and loss of mitochondrial Omi/HtrA2 is associated with S-nitrosoglutathione-induced apoptosis in human endothelial cells.

Liu QB, Liu LL, Lu YM, Tao RR, Huang JY, Han F, Lou YJ.

Toxicol Appl Pharmacol. 2010 May 1;244(3):374-84. doi: 10.1016/j.taap.2010.02.004. Epub 2010 Feb 11. Erratum in: Toxicol Appl Pharmacol. 2010 Aug 15;247(1):70. Shioda, Norifumi [removed]; Moriguchi, Shigeki [removed]; Fukunaga, Kohji [removed].

PMID:
20153346
[PubMed - indexed for MEDLINE]
14.

Loss of Omi mitochondrial protease activity causes the neuromuscular disorder of mnd2 mutant mice.

Jones JM, Datta P, Srinivasula SM, Ji W, Gupta S, Zhang Z, Davies E, Hajnóczky G, Saunders TL, Van Keuren ML, Fernandes-Alnemri T, Meisler MH, Alnemri ES.

Nature. 2003 Oct 16;425(6959):721-7. Epub 2003 Oct 8.

PMID:
14534547
[PubMed - indexed for MEDLINE]
Free Article
15.

Mpv17l protects against mitochondrial oxidative stress and apoptosis by activation of Omi/HtrA2 protease.

Krick S, Shi S, Ju W, Faul C, Tsai SY, Mundel P, Böttinger EP.

Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):14106-11. doi: 10.1073/pnas.0801146105. Epub 2008 Sep 4.

PMID:
18772386
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

The mitochondrial serine protease HtrA2/Omi cleaves RIP1 during apoptosis of Ba/F3 cells induced by growth factor withdrawal.

Vande Walle L, Wirawan E, Lamkanfi M, Festjens N, Verspurten J, Saelens X, Vanden Berghe T, Vandenabeele P.

Cell Res. 2010 Apr;20(4):421-33. doi: 10.1038/cr.2010.18. Epub 2010 Feb 2.

PMID:
20125124
[PubMed - indexed for MEDLINE]
17.

A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis.

Park JS, Sharma LK, Li H, Xiang R, Holstein D, Wu J, Lechleiter J, Naylor SL, Deng JJ, Lu J, Bai Y.

Hum Mol Genet. 2009 May 1;18(9):1578-89. doi: 10.1093/hmg/ddp069. Epub 2009 Feb 10.

PMID:
19208652
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death.

Balakrishnan MP, Cilenti L, Mashak Z, Popat P, Alnemri ES, Zervos AS.

Am J Physiol Heart Circ Physiol. 2009 Aug;297(2):H643-53. doi: 10.1152/ajpheart.00234.2009. Epub 2009 Jun 5.

PMID:
19502560
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Loss of function mutations in the gene encoding Omi/HtrA2 in Parkinson's disease.

Strauss KM, Martins LM, Plun-Favreau H, Marx FP, Kautzmann S, Berg D, Gasser T, Wszolek Z, Müller T, Bornemann A, Wolburg H, Downward J, Riess O, Schulz JB, Krüger R.

Hum Mol Genet. 2005 Aug 1;14(15):2099-111. Epub 2005 Jun 16.

PMID:
15961413
[PubMed - indexed for MEDLINE]
Free Article
20.

Transgenic mice with neuron-specific overexpression of HtrA2/Omi suggest a neuroprotective role for HtrA2/Omi.

Liu MJ, Liu ML, Shen YF, Kim JM, Lee BH, Lee YS, Hong ST.

Biochem Biophys Res Commun. 2007 Oct 19;362(2):295-300. Epub 2007 Aug 1.

PMID:
17707776
[PubMed - indexed for MEDLINE]
Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk