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Results: 1 to 20 of 143

1.

Human metabolites of synthetic cannabinoids JWH-018 and JWH-073 bind with high affinity and act as potent agonists at cannabinoid type-2 receptors.

Rajasekaran M, Brents LK, Franks LN, Moran JH, Prather PL.

Toxicol Appl Pharmacol. 2013 Jun 1;269(2):100-8. doi: 10.1016/j.taap.2013.03.012. Epub 2013 Mar 26.

PMID:
23537664
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Phase I hydroxylated metabolites of the K2 synthetic cannabinoid JWH-018 retain in vitro and in vivo cannabinoid 1 receptor affinity and activity.

Brents LK, Reichard EE, Zimmerman SM, Moran JH, Fantegrossi WE, Prather PL.

PLoS One. 2011;6(7):e21917. doi: 10.1371/journal.pone.0021917. Epub 2011 Jul 6.

PMID:
21755008
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity.

Brents LK, Gallus-Zawada A, Radominska-Pandya A, Vasiljevik T, Prisinzano TE, Fantegrossi WE, Moran JH, Prather PL.

Biochem Pharmacol. 2012 Apr 1;83(7):952-61. doi: 10.1016/j.bcp.2012.01.004. Epub 2012 Jan 18.

PMID:
22266354
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Distinct pharmacology and metabolism of K2 synthetic cannabinoids compared to Δ(9)-THC: mechanism underlying greater toxicity?

Fantegrossi WE, Moran JH, Radominska-Pandya A, Prather PL.

Life Sci. 2014 Feb 27;97(1):45-54. doi: 10.1016/j.lfs.2013.09.017. Epub 2013 Sep 29. Review.

PMID:
24084047
[PubMed - indexed for MEDLINE]
5.

CB1 and CB2 receptors are novel molecular targets for Tamoxifen and 4OH-Tamoxifen.

Prather PL, FrancisDevaraj F, Dates CR, Greer AK, Bratton SM, Ford BM, Franks LN, Radominska-Pandya A.

Biochem Biophys Res Commun. 2013 Nov 15;441(2):339-43. doi: 10.1016/j.bbrc.2013.10.057. Epub 2013 Oct 19.

PMID:
24148245
[PubMed - indexed for MEDLINE]
6.

Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands.

Chimalakonda KC, Seely KA, Bratton SM, Brents LK, Moran CL, Endres GW, James LP, Hollenberg PF, Prather PL, Radominska-Pandya A, Moran JH.

Drug Metab Dispos. 2012 Nov;40(11):2174-84. doi: 10.1124/dmd.112.047530. Epub 2012 Aug 17.

PMID:
22904561
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

A major glucuronidated metabolite of JWH-018 is a neutral antagonist at CB1 receptors.

Seely KA, Brents LK, Radominska-Pandya A, Endres GW, Keyes GS, Moran JH, Prather PL.

Chem Res Toxicol. 2012 Apr 16;25(4):825-7. doi: 10.1021/tx3000472. Epub 2012 Mar 15.

PMID:
22404317
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: implications for opioid/cannabinoid interaction studies.

Seely KA, Brents LK, Franks LN, Rajasekaran M, Zimmerman SM, Fantegrossi WE, Prather PL.

Neuropharmacology. 2012 Oct;63(5):905-15. doi: 10.1016/j.neuropharm.2012.06.046. Epub 2012 Jul 4.

PMID:
22771770
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

1-Pentyl-3-phenylacetylindoles and JWH-018 share in vivo cannabinoid profiles in mice.

Wiley JL, Marusich JA, Martin BR, Huffman JW.

Drug Alcohol Depend. 2012 Jun 1;123(1-3):148-53. doi: 10.1016/j.drugalcdep.2011.11.001. Epub 2011 Nov 27.

PMID:
22127210
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles.

Huffman JW, Szklennik PV, Almond A, Bushell K, Selley DE, He H, Cassidy MP, Wiley JL, Martin BR.

Bioorg Med Chem Lett. 2005 Sep 15;15(18):4110-3.

PMID:
16005223
[PubMed - indexed for MEDLINE]
11.

Screening for the synthetic cannabinoid JWH-018 and its major metabolites in human doping controls.

Möller I, Wintermeyer A, Bender K, Jübner M, Thomas A, Krug O, Schänzer W, Thevis M.

Drug Test Anal. 2011 Sep;3(9):609-20. doi: 10.1002/dta.158. Epub 2010 Sep 24.

PMID:
20872894
[PubMed - indexed for MEDLINE]
12.

Moving around the molecule: relationship between chemical structure and in vivo activity of synthetic cannabinoids.

Wiley JL, Marusich JA, Huffman JW.

Life Sci. 2014 Feb 27;97(1):55-63. doi: 10.1016/j.lfs.2013.09.011. Epub 2013 Sep 23. Review.

PMID:
24071522
[PubMed - indexed for MEDLINE]
13.

Structure-activity relationships for 1-alkyl-3-(1-naphthoyl)indoles at the cannabinoid CB(1) and CB(2) receptors: steric and electronic effects of naphthoyl substituents. New highly selective CB(2) receptor agonists.

Huffman JW, Zengin G, Wu MJ, Lu J, Hynd G, Bushell K, Thompson AL, Bushell S, Tartal C, Hurst DP, Reggio PH, Selley DE, Cassidy MP, Wiley JL, Martin BR.

Bioorg Med Chem. 2005 Jan 3;13(1):89-112.

PMID:
15582455
[PubMed - indexed for MEDLINE]
14.

Synthetic cannabinoid receptor agonists inhibit tumor growth and metastasis of breast cancer.

Qamri Z, Preet A, Nasser MW, Bass CE, Leone G, Barsky SH, Ganju RK.

Mol Cancer Ther. 2009 Nov;8(11):3117-29. doi: 10.1158/1535-7163.MCT-09-0448. Epub 2009 Nov 3.

PMID:
19887554
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Apparent inverse relationship between cannabinoid agonist efficacy and tolerance/cross-tolerance produced by Δ⁹-tetrahydrocannabinol treatment in rhesus monkeys.

Hruba L, Ginsburg BC, McMahon LR.

J Pharmacol Exp Ther. 2012 Sep;342(3):843-9. doi: 10.1124/jpet.112.196444. Epub 2012 Jun 20.

PMID:
22718500
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Conjugation of synthetic cannabinoids JWH-018 and JWH-073, metabolites by human UDP-glucuronosyltransferases.

Chimalakonda KC, Bratton SM, Le VH, Yiew KH, Dineva A, Moran CL, James LP, Moran JH, Radominska-Pandya A.

Drug Metab Dispos. 2011 Oct;39(10):1967-76. doi: 10.1124/dmd.111.040709. Epub 2011 Jul 11.

PMID:
21746969
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Differential drug-drug interactions of the synthetic Cannabinoids JWH-018 and JWH-073: implications for drug abuse liability and pain therapy.

Brents LK, Zimmerman SM, Saffell AR, Prather PL, Fantegrossi WE.

J Pharmacol Exp Ther. 2013 Sep;346(3):350-61. doi: 10.1124/jpet.113.206003. Epub 2013 Jun 25.

PMID:
23801678
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Liquid chromatography-tandem mass spectrometry analysis of urine specimens for K2 (JWH-018) metabolites.

ElSohly MA, Gul W, Elsohly KM, Murphy TP, Madgula VL, Khan SI.

J Anal Toxicol. 2011 Sep;35(7):487-95.

PMID:
21871158
[PubMed - indexed for MEDLINE]
Free Article
19.

Cannabinoid CB1 and CB2 receptor ligand specificity and the development of CB2-selective agonists.

Ashton JC, Wright JL, McPartland JM, Tyndall JD.

Curr Med Chem. 2008;15(14):1428-43. Review.

PMID:
18537620
[PubMed - indexed for MEDLINE]
20.

Comparison of cannabinoid ligands affinities and efficacies in murine tissues and in transfected cells expressing human recombinant cannabinoid receptors.

Govaerts SJ, Hermans E, Lambert DM.

Eur J Pharm Sci. 2004 Nov;23(3):233-43.

PMID:
15489124
[PubMed - indexed for MEDLINE]

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