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Results: 1 to 20 of 472

1.

Protein phosphatase 2A and DNA-dependent protein kinase are involved in mediating rapamycin-induced Akt phosphorylation.

Li Y, Wang X, Yue P, Tao H, Ramalingam SS, Owonikoko TK, Deng X, Wang Y, Fu H, Khuri FR, Sun SY.

J Biol Chem. 2013 May 10;288(19):13215-24. doi: 10.1074/jbc.M113.463679. Epub 2013 Mar 27.

PMID:
23536185
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival.

Tu Y, Ji C, Yang B, Yang Z, Gu H, Lu CC, Wang R, Su ZL, Chen B, Sun WL, Xia JP, Bi ZG, He L.

Mol Cancer. 2013 Dec 24;12(1):172. doi: 10.1186/1476-4598-12-172.

PMID:
24365180
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Feedback loops blockade potentiates apoptosis induction and antitumor activity of a novel AKT inhibitor DC120 in human liver cancer.

Yang F, Deng R, Qian XJ, Chang SH, Wu XQ, Qin J, Feng GK, Ding K, Zhu XF.

Cell Death Dis. 2014 Mar 13;5:e1114. doi: 10.1038/cddis.2014.43.

PMID:
24625973
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Enhancing mammalian target of rapamycin (mTOR)-targeted cancer therapy by preventing mTOR/raptor inhibition-initiated, mTOR/rictor-independent Akt activation.

Wang X, Yue P, Kim YA, Fu H, Khuri FR, Sun SY.

Cancer Res. 2008 Sep 15;68(18):7409-18. doi: 10.1158/0008-5472.CAN-08-1522.

PMID:
18794129
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

The ATM inhibitor KU-55933 suppresses cell proliferation and induces apoptosis by blocking Akt in cancer cells with overactivated Akt.

Li Y, Yang DQ.

Mol Cancer Ther. 2010 Jan;9(1):113-25. doi: 10.1158/1535-7163.MCT-08-1189. Epub 2010 Jan 6.

PMID:
20053781
[PubMed - indexed for MEDLINE]
Free Article
6.

SOX2 promotes tumor growth of esophageal squamous cell carcinoma through the AKT/mammalian target of rapamycin complex 1 signaling pathway.

Gen Y, Yasui K, Nishikawa T, Yoshikawa T.

Cancer Sci. 2013 Jul;104(7):810-6. doi: 10.1111/cas.12155. Epub 2013 Apr 16.

PMID:
23510069
[PubMed - indexed for MEDLINE]
7.

Rapamycin inhibits IGF-1 stimulated cell motility through PP2A pathway.

Liu L, Chen L, Luo Y, Chen W, Zhou H, Xu B, Han X, Shen T, Huang S.

PLoS One. 2010 May 11;5(5):e10578. doi: 10.1371/journal.pone.0010578.

PMID:
20485667
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Okadaic acid induces Akt hyperphosphorylation and an oxidative stress-mediated cell death in serum starved SK-N-SH human neuroblastoma cells that are augmented by rapamycin.

Edelstein J, Rockwell P.

Neurosci Lett. 2012 Dec 7;531(2):74-9. doi: 10.1016/j.neulet.2012.10.052. Epub 2012 Nov 2.

PMID:
23127854
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

mTORC1 signaling can regulate growth factor activation of p44/42 mitogen-activated protein kinases through protein phosphatase 2A.

Harwood FC, Shu L, Houghton PJ.

J Biol Chem. 2008 Feb 1;283(5):2575-85. Epub 2007 Dec 4.

PMID:
18056704
[PubMed - indexed for MEDLINE]
Free Article
10.

Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma.

Vega F, Medeiros LJ, Leventaki V, Atwell C, Cho-Vega JH, Tian L, Claret FX, Rassidakis GZ.

Cancer Res. 2006 Jul 1;66(13):6589-97.

PMID:
16818631
[PubMed - indexed for MEDLINE]
Free Article
11.

High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma.

Ahmed M, Hussain AR, Bavi P, Ahmed SO, Al Sobhi SS, Al-Dayel F, Uddin S, Al-Kuraya KS.

Carcinogenesis. 2014 Jul;35(7):1564-72. doi: 10.1093/carcin/bgu051. Epub 2014 Feb 28.

PMID:
24583924
[PubMed - indexed for MEDLINE]
12.

A dual mTORC1 and mTORC2 inhibitor shows antitumor activity in esophageal squamous cell carcinoma cells and sensitizes them to cisplatin.

Huang Y, Xi Q, Chen Y, Wang J, Peng P, Xia S, Yu S.

Anticancer Drugs. 2013 Oct;24(9):889-98. doi: 10.1097/CAD.0b013e328363c64e.

PMID:
23838676
[PubMed - indexed for MEDLINE]
13.

Different patterns of Akt and ERK feedback activation in response to rapamycin, active-site mTOR inhibitors and metformin in pancreatic cancer cells.

Soares HP, Ni Y, Kisfalvi K, Sinnett-Smith J, Rozengurt E.

PLoS One. 2013;8(2):e57289. doi: 10.1371/journal.pone.0057289. Epub 2013 Feb 21.

PMID:
23437362
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.

Gulati N, Karsy M, Albert L, Murali R, Jhanwar-Uniyal M.

Int J Oncol. 2009 Oct;35(4):731-40.

PMID:
19724909
[PubMed - indexed for MEDLINE]
15.

Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IκB kinase α (IKKα).

Dan HC, Ebbs A, Pasparakis M, Van Dyke T, Basseres DS, Baldwin AS.

J Biol Chem. 2014 Sep 5;289(36):25227-40. doi: 10.1074/jbc.M114.554881. Epub 2014 Jul 2.

PMID:
24990947
[PubMed - indexed for MEDLINE]
16.

Threonine-120 phosphorylation regulated by phosphoinositide-3-kinase/Akt and mammalian target of rapamycin pathway signaling limits the antitumor activity of mammalian sterile 20-like kinase 1.

Collak FK, Yagiz K, Luthringer DJ, Erkaya B, Cinar B.

J Biol Chem. 2012 Jul 6;287(28):23698-709. doi: 10.1074/jbc.M112.358713. Epub 2012 May 22.

PMID:
22619175
[PubMed - indexed for MEDLINE]
Free PMC Article
17.

Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild-type and BK5.AktWT mice.

Rho O, Kiguchi K, Jiang G, DiGiovanni J.

Mol Carcinog. 2014 Nov;53(11):871-82. doi: 10.1002/mc.22046. Epub 2013 Sep 20.

PMID:
24114993
[PubMed - indexed for MEDLINE]
18.
19.

Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2.

Gupta M, Ansell SM, Novak AJ, Kumar S, Kaufmann SH, Witzig TE.

Blood. 2009 Oct 1;114(14):2926-35. doi: 10.1182/blood-2009-05-220889. Epub 2009 Jul 29.

PMID:
19641186
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

Vascular tumors have increased p70 S6-kinase activation and are inhibited by topical rapamycin.

Du W, Gerald D, Perruzzi CA, Rodriguez-Waitkus P, Enayati L, Krishnan B, Edmonds J, Hochman ML, Lev DC, Phung TL.

Lab Invest. 2013 Oct;93(10):1115-27. doi: 10.1038/labinvest.2013.98. Epub 2013 Aug 12.

PMID:
23938603
[PubMed - indexed for MEDLINE]
Free Article
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