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Items: 1 to 20 of 114

1.

Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 2.

Ohtawa M, Yamazaki H, Matsuda D, Ohshiro T, Rudel LL, Ōmura S, Tomoda H, Nagamitsu T.

Bioorg Med Chem Lett. 2013 May 1;23(9):2659-62. doi: 10.1016/j.bmcl.2013.02.088. Epub 2013 Mar 6.

PMID:
23535327
2.

Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3.

Ohtawa M, Yamazaki H, Ohte S, Matsuda D, Ohshiro T, Rudel LL, Ōmura S, Tomoda H, Nagamitsu T.

Bioorg Med Chem Lett. 2013 Jul 1;23(13):3798-801. doi: 10.1016/j.bmcl.2013.04.075. Epub 2013 May 8.

PMID:
23711919
3.

Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 1.

Ohtawa M, Yamazaki H, Ohte S, Matsuda D, Ohshiro T, Rudel LL, Omura S, Tomoda H, Nagamitsu T.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1285-7. doi: 10.1016/j.bmcl.2012.12.099. Epub 2013 Jan 9.

PMID:
23369538
4.

Penicillium griseofulvum F1959, high-production strain of pyripyropene a, specific inhibitor of acyl-CoA: cholesterol acyltransferase 2.

Choi JH, Rho MC, Lee SW, Choi JN, Lee HJ, Bae KS, Kim K, Kim YK.

J Microbiol Biotechnol. 2008 Oct;18(10):1663-5.

5.

Chemical modification and structure-activity relationships of pyripyropenes. 2. 1,11-Cyclic analogs.

Obata R, Sunazuka T, Kato Y, Tomoda H, Harigaya Y, Omura S.

J Antibiot (Tokyo). 1996 Nov;49(11):1149-56.

6.

Selectivity of pyripyropene derivatives in inhibition toward acyl-CoA:cholesterol acyltransferase 2 isozyme.

Ohshiro T, Ohte S, Matsuda D, Ohtawa M, Nagamitsu T, Sunazuka T, Harigaya Y, Rudel LL, Omura S, Tomoda H.

J Antibiot (Tokyo). 2008 Aug;61(8):503-8. doi: 10.1038/ja.2008.67.

PMID:
18997389
7.

Chemical modification and structure-activity relationships of pyripyropenes. 3. Synthetic conversion of pyridine-pyrone moiety.

Obata R, Sunazuka T, Tian Z, Tomoda H, Harigaya Y, Omura S.

J Antibiot (Tokyo). 1997 Mar;50(3):229-36.

8.

Pyripyropenes, novel ACAT inhibitors produced by Aspergillus fumigatus. IV. Structure elucidation of pyripyropenes M to R.

Tomoda H, Tabata N, Yang DJ, Namatame I, Tanaka H, Omura S, Kaneko T.

J Antibiot (Tokyo). 1996 Mar;49(3):292-8.

9.

Total synthesis of alpha-pyrone meroterpenoids, novel bioactive microbial metabolites.

Sunazuka T, Omura S.

Chem Rev. 2005 Dec;105(12):4559-80. Review. No abstract available.

PMID:
16351054
10.

New pyripyropene A derivatives, highly SOAT2-selective inhibitors, improve hypercholesterolemia and atherosclerosis in atherogenic mouse models.

Ohshiro T, Ohtawa M, Nagamitsu T, Matsuda D, Yagyu H, Davis MA, Rudel LL, Ishibashi S, Tomoda H.

J Pharmacol Exp Ther. 2015 Nov;355(2):299-307. doi: 10.1124/jpet.115.227348. Epub 2015 Sep 3.

PMID:
26338984
11.

Structure-activity relationships of pyripyropenes fungal acyl-CoA: cholesterol acyltransferase inhibitors.

Obata R, Sunazuka T, Li Z, Tomoda H, Omura S.

J Antibiot (Tokyo). 1995 Jul;48(7):749-50. No abstract available.

12.
13.

Chemical modification and structure-activity relationships of pyripyropenes. 1. Modification at the four hydroxyl groups.

Obata R, Sunazuka T, Li Z, Tian Z, Harigaya Y, Tabata N, Tomoda H, Omura S.

J Antibiot (Tokyo). 1996 Nov;49(11):1133-48.

14.

Identification of the interaction site within acyl-CoA:cholesterol acyltransferase 2 for the isoform-specific inhibitor pyripyropene A.

Das A, Davis MA, Tomoda H, Omura S, Rudel LL.

J Biol Chem. 2008 Apr 18;283(16):10453-60. doi: 10.1074/jbc.M709460200. Epub 2008 Feb 19.

15.
16.

Pyripyropene A, an acyl-coenzyme A:cholesterol acyltransferase 2-selective inhibitor, attenuates hypercholesterolemia and atherosclerosis in murine models of hyperlipidemia.

Ohshiro T, Matsuda D, Sakai K, Degirolamo C, Yagyu H, Rudel LL, Omura S, Ishibashi S, Tomoda H.

Arterioscler Thromb Vasc Biol. 2011 May;31(5):1108-15. doi: 10.1161/ATVBAHA.111.223552. Epub 2011 Mar 10.

17.

Pyripyropenes, Novel ACAT inhibitors produced by Aspergillus fumigatus. III. Structure elucidation of pyripyropenes E to L.

Tomoda H, Tabata N, Yang DJ, Takayanagi H, Nishida H, Omura S, Kaneko T.

J Antibiot (Tokyo). 1995 Jun;48(6):495-503.

18.

Selectivity of microbial acyl-CoA: cholesterol acyltransferase inhibitors toward isozymes.

Ohshiro T, Rudel LL, Omura S, Tomoda H.

J Antibiot (Tokyo). 2007 Jan;60(1):43-51.

PMID:
17390588
19.

Discovery and combinatorial synthesis of fungal metabolites beauveriolides, novel antiatherosclerotic agents.

Tomoda H, Doi T.

Acc Chem Res. 2008 Jan;41(1):32-9. Epub 2007 Sep 6. Review.

PMID:
17803269
20.

Novel 3,5-diaryl pyrazolines as human acyl-CoA:cholesterol acyltransferase inhibitors.

Jeong TS, Kim KS, An S, Cho KH, Lee S, Lee WS.

Bioorg Med Chem Lett. 2004 Jun 7;14(11):2715-7. Erratum in: Bioorg Med Chem Lett. 2009 Apr 15;19(8):2364. An, So-Jin [corrected to An, Sojin].

PMID:
15125920
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