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Results: 1 to 20 of 94

1.

Sustained overexpression of Redd1 leads to Akt activation involved in cell survival.

Jin HO, Hong SE, Kim JH, Choi HN, Kim K, An S, Choe TB, Hwang CS, Lee JH, Kim JI, Kim HA, Kim EK, Noh WC, Hong YJ, Hong SI, Lee JK, Park IC.

Cancer Lett. 2013 Aug 19;336(2):319-24. doi: 10.1016/j.canlet.2013.03.021. Epub 2013 Mar 22.

PMID:
23528835
[PubMed - indexed for MEDLINE]
2.

A dual mTORC1 and mTORC2 inhibitor shows antitumor activity in esophageal squamous cell carcinoma cells and sensitizes them to cisplatin.

Huang Y, Xi Q, Chen Y, Wang J, Peng P, Xia S, Yu S.

Anticancer Drugs. 2013 Oct;24(9):889-98. doi: 10.1097/CAD.0b013e328363c64e.

PMID:
23838676
[PubMed - indexed for MEDLINE]
3.

Inhibition of 14-3-3 binding to Rictor of mTORC2 for Akt phosphorylation at Ser473 is regulated by selenoprotein W.

Jeon YH, Park YH, Kwon JH, Lee JH, Kim IY.

Biochim Biophys Acta. 2013 Oct;1833(10):2135-42. doi: 10.1016/j.bbamcr.2013.05.005. Epub 2013 May 13.

PMID:
23680186
[PubMed - indexed for MEDLINE]
4.

mTORC1 and mTORC2 regulate insulin secretion through Akt in INS-1 cells.

Le Bacquer O, Queniat G, Gmyr V, Kerr-Conte J, Lefebvre B, Pattou F.

J Endocrinol. 2013 Jan 2;216(1):21-9. doi: 10.1530/JOE-12-0351. Print 2013 Jan.

PMID:
23092880
[PubMed - indexed for MEDLINE]
Free Article
5.

SNS-032 inhibits mTORC1/mTORC2 activity in acute myeloid leukemia cells and has synergistic activity with perifosine against Akt.

Meng H, Jin Y, Liu H, You L, Yang C, Yang X, Qian W.

J Hematol Oncol. 2013 Feb 18;6:18. doi: 10.1186/1756-8722-6-18.

PMID:
23415012
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.

Misra UK, Pizzo SV.

PLoS One. 2012;7(12):e51735. doi: 10.1371/journal.pone.0051735. Epub 2012 Dec 14.

PMID:
23272152
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Molecular dissection of AKT activation in lung cancer cell lines.

Guo Y, Du J, Kwiatkowski DJ.

Mol Cancer Res. 2013 Mar;11(3):282-93. doi: 10.1158/1541-7786.MCR-12-0558. Epub 2013 Jan 14.

PMID:
23319332
[PubMed - indexed for MEDLINE]
Free PMC Article
8.

Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition.

Breuleux M, Klopfenstein M, Stephan C, Doughty CA, Barys L, Maira SM, Kwiatkowski D, Lane HA.

Mol Cancer Ther. 2009 Apr;8(4):742-53. doi: 10.1158/1535-7163.MCT-08-0668.

PMID:
19372546
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.

Woo SY, Kim DH, Jun CB, Kim YM, Haar EV, Lee SI, Hegg JW, Bandhakavi S, Griffin TJ, Kim DH.

J Biol Chem. 2007 Aug 31;282(35):25604-12. Epub 2007 Jun 28.

PMID:
17599906
[PubMed - indexed for MEDLINE]
Free Article
10.

Combination of mTOR and EGFR kinase inhibitors blocks mTORC1 and mTORC2 kinase activity and suppresses the progression of colorectal carcinoma.

Wang Q, Wei F, Li C, Lv G, Wang G, Liu T, Bellail AC, Hao C.

PLoS One. 2013 Aug 22;8(8):e73175. doi: 10.1371/journal.pone.0073175. eCollection 2013.

PMID:
23991179
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex.

Misra UK, Pizzo SV.

J Cell Biochem. 2012 May;113(5):1488-500. doi: 10.1002/jcb.24018.

PMID:
22173835
[PubMed - indexed for MEDLINE]
12.

XPLN is an endogenous inhibitor of mTORC2.

Khanna N, Fang Y, Yoon MS, Chen J.

Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):15979-84. doi: 10.1073/pnas.1310434110. Epub 2013 Sep 16.

PMID:
24043828
[PubMed - indexed for MEDLINE]
Free PMC Article
13.

Cell cycle-dependent activity of the novel dual PI3K-MTORC1/2 inhibitor NVP-BGT226 in acute leukemia.

Kampa-Schittenhelm KM, Heinrich MC, Akmut F, Rasp KH, Illing B, Döhner H, Döhner K, Schittenhelm MM.

Mol Cancer. 2013 May 24;12:46. doi: 10.1186/1476-4598-12-46.

PMID:
23705826
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.

Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W.

Nat Cell Biol. 2013 Nov;15(11):1340-50. doi: 10.1038/ncb2860. Epub 2013 Oct 27.

PMID:
24161930
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Involvement of mTORC1 and mTORC2 in regulation of glioblastoma multiforme growth and motility.

Gulati N, Karsy M, Albert L, Murali R, Jhanwar-Uniyal M.

Int J Oncol. 2009 Oct;35(4):731-40.

PMID:
19724909
[PubMed - indexed for MEDLINE]
16.

Suppression of chloride channel 3 expression facilitates sensitivity of human glioma U251 cells to cisplatin through concomitant inhibition of Akt and autophagy.

Su J, Xu Y, Zhou L, Yu HM, Kang JS, Liu N, Quan CS, Sun LK.

Anat Rec (Hoboken). 2013 Apr;296(4):595-603. doi: 10.1002/ar.22665. Epub 2013 Feb 13.

PMID:
23408563
[PubMed - indexed for MEDLINE]
Free Article
17.

Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle.

White JP, Gao S, Puppa MJ, Sato S, Welle SL, Carson JA.

Mol Cell Endocrinol. 2013 Jan 30;365(2):174-86. doi: 10.1016/j.mce.2012.10.019. Epub 2012 Oct 29.

PMID:
23116773
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase subunit Fbw8.

Kim SJ, DeStefano MA, Oh WJ, Wu CC, Vega-Cotto NM, Finlan M, Liu D, Su B, Jacinto E.

Mol Cell. 2012 Dec 28;48(6):875-87. doi: 10.1016/j.molcel.2012.09.029. Epub 2012 Nov 8.

PMID:
23142081
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signaling.

Julien LA, Carriere A, Moreau J, Roux PP.

Mol Cell Biol. 2010 Feb;30(4):908-21. doi: 10.1128/MCB.00601-09. Epub 2009 Dec 7.

PMID:
19995915
[PubMed - indexed for MEDLINE]
Free PMC Article
20.

mTORC1 dependent regulation of REDD1 protein stability.

Tan CY, Hagen T.

PLoS One. 2013 May 22;8(5):e63970. doi: 10.1371/journal.pone.0063970. Print 2013.

PMID:
23717519
[PubMed - indexed for MEDLINE]
Free PMC Article

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