Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Results: 1 to 20 of 94

1.

Insight the C-site pocket conformational changes responsible for sirtuin 2 activity using molecular dynamics simulations.

Sakkiah S, Arooj M, Cao GP, Lee KW.

PLoS One. 2013;8(3):e59278. doi: 10.1371/journal.pone.0059278. Epub 2013 Mar 20.

PMID:
23527151
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Molecular modeling study for conformational changes of Sirtuin 2 due to substrate and inhibitor binding.

Sakkiah S, Chandrasekaran M, Lee Y, Kim S, Lee KW.

J Biomol Struct Dyn. 2012;30(3):235-54. doi: 10.1080/07391102.2012.680026. Epub 2012 Jun 12.

PMID:
22694102
[PubMed - indexed for MEDLINE]
3.

Identification of inhibitor binding site in human sirtuin 2 using molecular docking and dynamics simulations.

Sakkiah S, Arooj M, Kumar MR, Eom SH, Lee KW.

PLoS One. 2013;8(1):e51429. doi: 10.1371/journal.pone.0051429. Epub 2013 Jan 28.

PMID:
23382805
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Crystal structure analysis of human Sirt2 and its ADP-ribose complex.

Moniot S, Schutkowski M, Steegborn C.

J Struct Biol. 2013 May;182(2):136-43. doi: 10.1016/j.jsb.2013.02.012. Epub 2013 Feb 26.

PMID:
23454361
[PubMed - indexed for MEDLINE]
5.

Molecular docking and dynamics simulation, receptor-based hypothesis: application to identify novel sirtuin 2 inhibitors.

Sakkiah S, Thangapandian S, Park C, Son M, Lee KW.

Chem Biol Drug Des. 2012 Aug;80(2):315-27. doi: 10.1111/j.1747-0285.2012.01406.x. Epub 2012 Jun 21.

PMID:
22564257
[PubMed - indexed for MEDLINE]
6.

ERK1/2 regulates SIRT2 deacetylase activity.

Choi YH, Kim H, Lee SH, Jin YH, Lee KY.

Biochem Biophys Res Commun. 2013 Jul 26;437(2):245-9. doi: 10.1016/j.bbrc.2013.06.053. Epub 2013 Jun 24.

PMID:
23806683
[PubMed - indexed for MEDLINE]
7.

Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors.

Suzuki T, Khan MN, Sawada H, Imai E, Itoh Y, Yamatsuta K, Tokuda N, Takeuchi J, Seko T, Nakagawa H, Miyata N.

J Med Chem. 2012 Jun 28;55(12):5760-73. doi: 10.1021/jm3002108. Epub 2012 Jun 12.

PMID:
22642300
[PubMed - indexed for MEDLINE]
8.

Inhibition of the NAD-dependent protein deacetylase SIRT2 induces granulocytic differentiation in human leukemia cells.

Sunami Y, Araki M, Hironaka Y, Morishita S, Kobayashi M, Liew EL, Edahiro Y, Tsutsui M, Ohsaka A, Komatsu N.

PLoS One. 2013;8(2):e57633. doi: 10.1371/journal.pone.0057633. Epub 2013 Feb 27.

PMID:
23460888
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle.

Dryden SC, Nahhas FA, Nowak JE, Goustin AS, Tainsky MA.

Mol Cell Biol. 2003 May;23(9):3173-85.

PMID:
12697818
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3.

Disch JS, Evindar G, Chiu CH, Blum CA, Dai H, Jin L, Schuman E, Lind KE, Belyanskaya SL, Deng J, Coppo F, Aquilani L, Graybill TL, Cuozzo JW, Lavu S, Mao C, Vlasuk GP, Perni RB.

J Med Chem. 2013 May 9;56(9):3666-79. doi: 10.1021/jm400204k. Epub 2013 Apr 29.

PMID:
23570514
[PubMed - indexed for MEDLINE]
11.

Investigation of the catalytic mechanism of Sir2 enzyme with QM/MM approach: SN1 vs SN2?

Liang Z, Shi T, Ouyang S, Li H, Yu K, Zhu W, Luo C, Jiang H.

J Phys Chem B. 2010 Sep 16;114(36):11927-33. doi: 10.1021/jp1054183.

PMID:
20726530
[PubMed - indexed for MEDLINE]
12.

Structural basis for potent inhibition of SIRT2 deacetylase by a macrocyclic peptide inducing dynamic structural change.

Yamagata K, Goto Y, Nishimasu H, Morimoto J, Ishitani R, Dohmae N, Takeda N, Nagai R, Komuro I, Suga H, Nureki O.

Structure. 2014 Feb 4;22(2):345-52. doi: 10.1016/j.str.2013.12.001. Epub 2014 Jan 2.

PMID:
24389023
[PubMed - indexed for MEDLINE]
13.

FISH-mapping and genomic organization of the NAD-dependent histone deacetylase gene, Sirtuin 2 (Sirt2).

Voelter-Mahlknecht S, Ho AD, Mahlknecht U.

Int J Oncol. 2005 Nov;27(5):1187-96.

PMID:
16211212
[PubMed - indexed for MEDLINE]
14.

Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin.

Nahhas F, Dryden SC, Abrams J, Tainsky MA.

Mol Cell Biochem. 2007 Sep;303(1-2):221-30. Epub 2007 May 22.

PMID:
17516032
[PubMed - indexed for MEDLINE]
15.

Structure-based development of novel sirtuin inhibitors.

Schlicker C, Boanca G, Lakshminarasimhan M, Steegborn C.

Aging (Albany NY). 2011 Sep;3(9):852-72.

PMID:
21937767
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Structural insights of SIR2rp3 proteins as promising biotargets to fight against Chagas disease and leishmaniasis.

Sacconnay L, Smirlis D, Queiroz EF, Wolfender JL, Soares MB, Carrupt PA, Nurisso A.

Mol Biosyst. 2013 Sep;9(9):2223-30. doi: 10.1039/c3mb70180h.

PMID:
23799611
[PubMed - indexed for MEDLINE]
17.

Constitutive nuclear localization of an alternatively spliced sirtuin-2 isoform.

Rack JG, VanLinden MR, Lutter T, Aasland R, Ziegler M.

J Mol Biol. 2014 Apr 17;426(8):1677-91. doi: 10.1016/j.jmb.2013.10.027. Epub 2013 Oct 29.

PMID:
24177535
[PubMed - indexed for MEDLINE]
18.

The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.

North BJ, Marshall BL, Borra MT, Denu JM, Verdin E.

Mol Cell. 2003 Feb;11(2):437-44.

PMID:
12620231
[PubMed - indexed for MEDLINE]
19.

Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins).

Trapp J, Meier R, Hongwiset D, Kassack MU, Sippl W, Jung M.

ChemMedChem. 2007 Oct;2(10):1419-31.

PMID:
17628866
[PubMed - indexed for MEDLINE]
20.

Sirt2 interacts with 14-3-3 beta/gamma and down-regulates the activity of p53.

Jin YH, Kim YJ, Kim DW, Baek KH, Kang BY, Yeo CY, Lee KY.

Biochem Biophys Res Commun. 2008 Apr 11;368(3):690-5. doi: 10.1016/j.bbrc.2008.01.114. Epub 2008 Feb 4.

PMID:
18249187
[PubMed - indexed for MEDLINE]

Display Settings:

Format
Items per page
Sort by

Send to:

Choose Destination

Supplemental Content

Write to the Help Desk