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Items: 1 to 20 of 102

1.

Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection.

Lupfer C, Thomas PG, Anand PK, Vogel P, Milasta S, Martinez J, Huang G, Green M, Kundu M, Chi H, Xavier RJ, Green DR, Lamkanfi M, Dinarello CA, Doherty PC, Kanneganti TD.

Nat Immunol. 2013 May;14(5):480-8. doi: 10.1038/ni.2563. Epub 2013 Mar 24.

3.

Reactive oxygen species regulate caspase-11 expression and activation of the non-canonical NLRP3 inflammasome during enteric pathogen infection.

Lupfer CR, Anand PK, Liu Z, Stokes KL, Vogel P, Lamkanfi M, Kanneganti TD.

PLoS Pathog. 2014 Sep 25;10(9):e1004410. doi: 10.1371/journal.ppat.1004410. eCollection 2014 Sep.

4.

Inflammasome activation leads to Caspase-1-dependent mitochondrial damage and block of mitophagy.

Yu J, Nagasu H, Murakami T, Hoang H, Broderick L, Hoffman HM, Horng T.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15514-9. doi: 10.1073/pnas.1414859111. Epub 2014 Oct 13.

5.

Pathogenic Vibrio activate NLRP3 inflammasome via cytotoxins and TLR/nucleotide-binding oligomerization domain-mediated NF-kappa B signaling.

Toma C, Higa N, Koizumi Y, Nakasone N, Ogura Y, McCoy AJ, Franchi L, Uematsu S, Sagara J, Taniguchi S, Tsutsui H, Akira S, Tschopp J, Núñez G, Suzuki T.

J Immunol. 2010 May 1;184(9):5287-97. doi: 10.4049/jimmunol.0903536. Epub 2010 Mar 26.

6.

The role of Resveratrol-induced mitophagy/autophagy in peritoneal mesothelial cells inflammatory injury via NLRP3 inflammasome activation triggered by mitochondrial ROS.

Wu J, Li X, Zhu G, Zhang Y, He M, Zhang J.

Exp Cell Res. 2016 Feb 1;341(1):42-53. doi: 10.1016/j.yexcr.2016.01.014. Epub 2016 Jan 26.

PMID:
26825654
7.

Activation of NOD2/RIPK2 pathway induces mitochondrial injury to oligodendrocyte precursor cells in vitro and CNS demyelination in vivo.

Natarajan C, Yao SY, Zhang F, Sriram S.

J Neuroimmunol. 2013 Dec 15;265(1-2):51-60. doi: 10.1016/j.jneuroim.2013.09.009. Epub 2013 Oct 9.

PMID:
24169446
8.

Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy.

Jabir MS, Hopkins L, Ritchie ND, Ullah I, Bayes HK, Li D, Tourlomousis P, Lupton A, Puleston D, Simon AK, Bryant C, Evans TJ.

Autophagy. 2015;11(1):166-82. doi: 10.4161/15548627.2014.981915.

9.

Joint NOD2/RIPK2 signaling regulates IL-17 axis and contributes to the development of experimental arthritis.

Vieira SM, Cunha TM, França RF, Pinto LG, Talbot J, Turato WM, Lemos HP, Lima JB, Verri WA Jr, Almeida SC, Ferreira SH, Louzada-Junior P, Zamboni DS, Cunha FQ.

J Immunol. 2012 May 15;188(10):5116-22. doi: 10.4049/jimmunol.1004190. Epub 2012 Apr 9.

10.

Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage.

Bronner DN, Abuaita BH, Chen X, Fitzgerald KA, Nuñez G, He Y, Yin XM, O'Riordan MX.

Immunity. 2015 Sep 15;43(3):451-62. doi: 10.1016/j.immuni.2015.08.008. Epub 2015 Sep 1.

PMID:
26341399
11.

Carbon monoxide negatively regulates NLRP3 inflammasome activation in macrophages.

Jung SS, Moon JS, Xu JF, Ifedigbo E, Ryter SW, Choi AM, Nakahira K.

Am J Physiol Lung Cell Mol Physiol. 2015 May 15;308(10):L1058-67. doi: 10.1152/ajplung.00400.2014. Epub 2015 Mar 13.

12.

A dual role for receptor-interacting protein kinase 2 (RIP2) kinase activity in nucleotide-binding oligomerization domain 2 (NOD2)-dependent autophagy.

Homer CR, Kabi A, Marina-García N, Sreekumar A, Nesvizhskii AI, Nickerson KP, Chinnaiyan AM, Nuñez G, McDonald C.

J Biol Chem. 2012 Jul 20;287(30):25565-76. doi: 10.1074/jbc.M111.326835. Epub 2012 Jun 4.

13.

NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux.

He Y, Zeng MY, Yang D, Motro B, Núñez G.

Nature. 2016 Feb 18;530(7590):354-7. doi: 10.1038/nature16959. Epub 2016 Jan 27.

PMID:
26814970
14.

The ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunity.

Damgaard RB, Nachbur U, Yabal M, Wong WW, Fiil BK, Kastirr M, Rieser E, Rickard JA, Bankovacki A, Peschel C, Ruland J, Bekker-Jensen S, Mailand N, Kaufmann T, Strasser A, Walczak H, Silke J, Jost PJ, Gyrd-Hansen M.

Mol Cell. 2012 Jun 29;46(6):746-58. doi: 10.1016/j.molcel.2012.04.014. Epub 2012 May 17.

15.

RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptive immune systems.

Kobayashi K, Inohara N, Hernandez LD, Galán JE, Núñez G, Janeway CA, Medzhitov R, Flavell RA.

Nature. 2002 Mar 14;416(6877):194-9.

PMID:
11894098
16.

Thyroid hormone induction of mitochondrial activity is coupled to mitophagy via ROS-AMPK-ULK1 signaling.

Sinha RA, Singh BK, Zhou J, Wu Y, Farah BL, Ohba K, Lesmana R, Gooding J, Bay BH, Yen PM.

Autophagy. 2015;11(8):1341-57. doi: 10.1080/15548627.2015.1061849.

PMID:
26103054
17.

ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy.

Wu W, Tian W, Hu Z, Chen G, Huang L, Li W, Zhang X, Xue P, Zhou C, Liu L, Zhu Y, Zhang X, Li L, Zhang L, Sui S, Zhao B, Feng D.

EMBO Rep. 2014 May;15(5):566-75. doi: 10.1002/embr.201438501. Epub 2014 Mar 26.

18.

Yersinia pseudotuberculosis effector YopJ subverts the Nod2/RICK/TAK1 pathway and activates caspase-1 to induce intestinal barrier dysfunction.

Meinzer U, Barreau F, Esmiol-Welterlin S, Jung C, Villard C, Léger T, Ben-Mkaddem S, Berrebi D, Dussaillant M, Alnabhani Z, Roy M, Bonacorsi S, Wolf-Watz H, Perroy J, Ollendorff V, Hugot JP.

Cell Host Microbe. 2012 Apr 19;11(4):337-51. doi: 10.1016/j.chom.2012.02.009.

19.

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.

Gross O, Poeck H, Bscheider M, Dostert C, Hannesschläger N, Endres S, Hartmann G, Tardivel A, Schweighoffer E, Tybulewicz V, Mocsai A, Tschopp J, Ruland J.

Nature. 2009 May 21;459(7245):433-6. doi: 10.1038/nature07965. Epub 2009 Apr 1.

PMID:
19339971
20.

Cyclooxygenase-2 regulates NLRP3 inflammasome-derived IL-1β production.

Hua KF, Chou JC, Ka SM, Tasi YL, Chen A, Wu SH, Chiu HW, Wong WT, Wang YF, Tsai CL, Ho CL, Lin CH.

J Cell Physiol. 2015 Apr;230(4):863-74. doi: 10.1002/jcp.24815.

PMID:
25294243
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