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Low-dose arsenic induces chemotherapy protection via p53/NF-κB-mediated metabolic regulation.

Ganapathy S, Xiao S, Seo SJ, Lall R, Yang M, Xu T, Su H, Shadfan M, Ha CS, Yuan ZM.

Oncogene. 2014 Mar 13;33(11):1359-66. doi: 10.1038/onc.2013.81. Epub 2013 Mar 25.


A low-dose arsenic-induced p53 protein-mediated metabolic mechanism of radiotherapy protection.

Ganapathy S, Xiao S, Yang M, Qi M, Choi DE, Ha CS, Little JB, Yuan ZM.

J Biol Chem. 2014 Feb 21;289(8):5340-7. doi: 10.1074/jbc.M113.531020. Epub 2014 Jan 3.


Nuclear factor-(kappa)B modulates the p53 response in neurons exposed to DNA damage.

Aleyasin H, Cregan SP, Iyirhiaro G, O'Hare MJ, Callaghan SM, Slack RS, Park DS.

J Neurosci. 2004 Mar 24;24(12):2963-73.


The molecular mechanisms of arsenic-induced cell transformation and apoptosis.

Dong Z.

Environ Health Perspect. 2002 Oct;110 Suppl 5:757-9.


Aurora-A promotes gefitinib resistance via a NF-κB signaling pathway in p53 knockdown lung cancer cells.

Wu CC, Yu CT, Chang GC, Lai JM, Hsu SL.

Biochem Biophys Res Commun. 2011 Feb 11;405(2):168-72. doi: 10.1016/j.bbrc.2011.01.001. Epub 2011 Jan 7.


The repressive effect of NF-kappaB on p53 by mot-2 is involved in human keratinocyte transformation induced by low levels of arsenite.

Li Y, Ling M, Xu Y, Wang S, Li Z, Zhou J, Wang X, Liu Q.

Toxicol Sci. 2010 Jul;116(1):174-82. doi: 10.1093/toxsci/kfq109. Epub 2010 Apr 7.


Dual targeting of transformed and untransformed HTLV-1-infected T cells by DHMEQ, a potent and selective inhibitor of NF-kappaB, as a strategy for chemoprevention and therapy of adult T-cell leukemia.

Watanabe M, Ohsugi T, Shoda M, Ishida T, Aizawa S, Maruyama-Nagai M, Utsunomiya A, Koga S, Yamada Y, Kamihira S, Okayama A, Kikuchi H, Uozumi K, Yamaguchi K, Higashihara M, Umezawa K, Watanabe T, Horie R.

Blood. 2005 Oct 1;106(7):2462-71. Epub 2005 Jun 14.


Docosahexaenoic acid sensitizes Ramos cells to Gamma-irradiation-induced apoptosis through involvement of PPAR-gamma activation and NF-kappaB suppression.

Zand H, Rahimipour A, Salimi S, Shafiee SM.

Mol Cell Biochem. 2008 Oct;317(1-2):113-20. doi: 10.1007/s11010-008-9838-x. Epub 2008 Jun 20.


Signaling from p53 to NF-kappaB determines the chemotherapy responsiveness of neuroblastoma.

Armstrong MB, Bian X, Liu Y, Subramanian C, Ratanaproeksa AB, Shao F, Yu VC, Kwok RP, Opipari AW Jr, Castle VP.

Neoplasia. 2006 Nov;8(11):967-77.


Functional p53 is required for triptolide-induced apoptosis and AP-1 and nuclear factor-kappaB activation in gastric cancer cells.

Jiang XH, Wong BC, Lin MC, Zhu GH, Kung HF, Jiang SH, Yang D, Lam SK.

Oncogene. 2001 Nov 29;20(55):8009-18.


Reciprocal inhibition of p53 and nuclear factor-kappaB transcriptional activities determines cell survival or death in neurons.

Culmsee C, Siewe J, Junker V, Retiounskaia M, Schwarz S, Camandola S, El-Metainy S, Behnke H, Mattson MP, Krieglstein J.

J Neurosci. 2003 Sep 17;23(24):8586-95.


The canonical NF-κB pathway differentially protects normal and human tumor cells from ROS-induced DNA damage.

Sfikas A, Batsi C, Tselikou E, Vartholomatos G, Monokrousos N, Pappas P, Christoforidis S, Tzavaras T, Kanavaros P, Gorgoulis VG, Marcu KB, Kolettas E.

Cell Signal. 2012 Nov;24(11):2007-23. doi: 10.1016/j.cellsig.2012.06.010. Epub 2012 Jun 29.


Physalin A induces apoptosis via p53-Noxa-mediated ROS generation, and autophagy plays a protective role against apoptosis through p38-NF-κB survival pathway in A375-S2 cells.

He H, Zang LH, Feng YS, Chen LX, Kang N, Tashiro S, Onodera S, Qiu F, Ikejima T.

J Ethnopharmacol. 2013 Jul 9;148(2):544-55. doi: 10.1016/j.jep.2013.04.051. Epub 2013 May 14.


A critical role for IkappaB kinase beta in metallothionein-1 expression and protection against arsenic toxicity.

Peng Z, Peng L, Fan Y, Zandi E, Shertzer HG, Xia Y.

J Biol Chem. 2007 Jul 20;282(29):21487-96. Epub 2007 May 25.


Glycolysis links p53 function with NF-kappaB signaling: impact on cancer and aging process.

Salminen A, Kaarniranta K.

J Cell Physiol. 2010 Jul;224(1):1-6. doi: 10.1002/jcp.22119. Review.


Anti-cancer activity of a novel small molecule compound that simultaneously activates p53 and inhibits NF-κB signaling.

Hwang SG, Park J, Park JY, Park CH, Lee KH, Cho JW, Hwang JI, Seong JY.

PLoS One. 2012;7(9):e44259. doi: 10.1371/journal.pone.0044259. Epub 2012 Sep 13.

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