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Results: 1 to 20 of 112

1.

Potency optimization of Huwentoxin-IV on hNav1.7: a neurotoxin TTX-S sodium-channel antagonist from the venom of the Chinese bird-eating spider Selenocosmia huwena.

Revell JD, Lund PE, Linley JE, Metcalfe J, Burmeister N, Sridharan S, Jones C, Jermutus L, Bednarek MA.

Peptides. 2013 Jun;44:40-6. doi: 10.1016/j.peptides.2013.03.011. Epub 2013 Mar 19.

PMID:
23523779
[PubMed - indexed for MEDLINE]
2.

Function and solution structure of huwentoxin-IV, a potent neuronal tetrodotoxin (TTX)-sensitive sodium channel antagonist from Chinese bird spider Selenocosmia huwena.

Peng K, Shu Q, Liu Z, Liang S.

J Biol Chem. 2002 Dec 6;277(49):47564-71. Epub 2002 Sep 11. Erratum in: J Biol Chem. 2003 Feb 14;278(7):5489..

PMID:
12228241
[PubMed - indexed for MEDLINE]
Free Article
3.

Structure and function of hainantoxin-III, a selective antagonist of neuronal tetrodotoxin-sensitive voltage-gated sodium channels isolated from the Chinese bird spider Ornithoctonus hainana.

Liu Z, Cai T, Zhu Q, Deng M, Li J, Zhou X, Zhang F, Li D, Li J, Liu Y, Hu W, Liang S.

J Biol Chem. 2013 Jul 12;288(28):20392-403. doi: 10.1074/jbc.M112.426627. Epub 2013 May 23.

PMID:
23703613
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Tarantula huwentoxin-IV inhibits neuronal sodium channels by binding to receptor site 4 and trapping the domain ii voltage sensor in the closed configuration.

Xiao Y, Bingham JP, Zhu W, Moczydlowski E, Liang S, Cummins TR.

J Biol Chem. 2008 Oct 3;283(40):27300-13. doi: 10.1074/jbc.M708447200. Epub 2008 Jul 14.

PMID:
18628201
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Synthesis and biological characterization of synthetic analogs of Huwentoxin-IV (Mu-theraphotoxin-Hh2a), a neuronal tetrodotoxin-sensitive sodium channel inhibitor.

Deng M, Luo X, Jiang L, Chen H, Wang J, He H, Liang S.

Toxicon. 2013 Sep;71:57-65. doi: 10.1016/j.toxicon.2013.05.015. Epub 2013 May 29.

PMID:
23726857
[PubMed - indexed for MEDLINE]
6.

Native pyroglutamation of huwentoxin-IV: a post-translational modification that increases the trapping ability to the sodium channel.

Rong M, Duan Z, Chen J, Li J, Xiao Y, Liang S.

PLoS One. 2013 Jun 24;8(6):e65984. doi: 10.1371/journal.pone.0065984. Print 2013.

PMID:
23826086
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Analysis of the structural and molecular basis of voltage-sensitive sodium channel inhibition by the spider toxin huwentoxin-IV (μ-TRTX-Hh2a).

Minassian NA, Gibbs A, Shih AY, Liu Y, Neff RA, Sutton SW, Mirzadegan T, Connor J, Fellows R, Husovsky M, Nelson S, Hunter MJ, Flinspach M, Wickenden AD.

J Biol Chem. 2013 Aug 2;288(31):22707-20. doi: 10.1074/jbc.M113.461392. Epub 2013 Jun 12.

PMID:
23760503
[PubMed - indexed for MEDLINE]
8.

Synthesis and characterization of huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channels.

Xiao Y, Luo X, Kuang F, Deng M, Wang M, Zeng X, Liang S.

Toxicon. 2008 Feb;51(2):230-9. Epub 2007 Sep 29.

PMID:
18054060
[PubMed - indexed for MEDLINE]
9.

The tarantula toxins ProTx-II and huwentoxin-IV differentially interact with human Nav1.7 voltage sensors to inhibit channel activation and inactivation.

Xiao Y, Blumenthal K, Jackson JO 2nd, Liang S, Cummins TR.

Mol Pharmacol. 2010 Dec;78(6):1124-34. doi: 10.1124/mol.110.066332. Epub 2010 Sep 20.

PMID:
20855463
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

A positively charged surface patch is important for hainantoxin-IV binding to voltage-gated sodium channels.

Liu Y, Li D, Wu Z, Li J, Nie D, Xiang Y, Liu Z.

J Pept Sci. 2012 Oct;18(10):643-9. doi: 10.1002/psc.2451. Epub 2012 Aug 27.

PMID:
22927181
[PubMed - indexed for MEDLINE]
11.

Function and solution structure of Huwentoxin-X, a specific blocker of N-type calcium channels, from the Chinese bird spider Ornithoctonus huwena.

Liu Z, Dai J, Dai L, Deng M, Hu Z, Hu W, Liang S.

J Biol Chem. 2006 Mar 31;281(13):8628-35. Epub 2006 Jan 26.

PMID:
16439354
[PubMed - indexed for MEDLINE]
Free Article
12.

Isolation and characterization of hainantoxin-IV, a novel antagonist of tetrodotoxin-sensitive sodium channels from the Chinese bird spider Selenocosmia hainana.

Liu Z, Dai J, Chen Z, Hu W, Xiao Y, Liang S.

Cell Mol Life Sci. 2003 May;60(5):972-8.

PMID:
12827284
[PubMed - indexed for MEDLINE]
13.
15.

Common molecular determinants of tarantula huwentoxin-IV inhibition of Na+ channel voltage sensors in domains II and IV.

Xiao Y, Jackson JO 2nd, Liang S, Cummins TR.

J Biol Chem. 2011 Aug 5;286(31):27301-10. doi: 10.1074/jbc.M111.246876. Epub 2011 Jun 9.

PMID:
21659528
[PubMed - indexed for MEDLINE]
Free PMC Article
16.

Characterization of a novel peptide toxin from Acanthoscurria paulensis spider venom: a distinct cysteine assignment to the HWTX-II family.

Mourão CB, Heghinian MD, Barbosa EA, Marí F, Bloch C Jr, Restano-Cassulini R, Possani LD, Schwartz EF.

Biochemistry. 2013 Apr 9;52(14):2440-52. doi: 10.1021/bi4000035. Epub 2013 Mar 29.

PMID:
23496776
[PubMed - indexed for MEDLINE]
17.

The cross channel activities of spider neurotoxin huwentoxin-I on rat dorsal root ganglion neurons.

Wang M, Guan X, Liang S.

Biochem Biophys Res Commun. 2007 Jun 8;357(3):579-83. Epub 2007 Apr 9.

PMID:
17451655
[PubMed - indexed for MEDLINE]
18.

Functional expression of spider neurotoxic peptide huwentoxin-I in E. coli.

Meng E, Cai TF, Li WY, Zhang H, Liu YB, Peng K, Liang S, Zhang DY.

PLoS One. 2011;6(6):e21608. doi: 10.1371/journal.pone.0021608. Epub 2011 Jun 23.

PMID:
21731778
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Inhibition of insect calcium channels by huwentoxin-V, a neurotoxin from Chinese tarantula Ornithoctonus huwena venom.

Deng M, Luo X, Meng E, Xiao Y, Liang S.

Eur J Pharmacol. 2008 Mar 17;582(1-3):12-6. doi: 10.1016/j.ejphar.2007.12.014. Epub 2007 Dec 27.

PMID:
18234186
[PubMed - indexed for MEDLINE]
20.

Properties and amino acid sequence of huwentoxin-I, a neurotoxin purified from the venom of the Chinese bird spider Selenocosmia huwena.

Liang SP, Zhang DY, Pan X, Chen Q, Zhou PA.

Toxicon. 1993 Aug;31(8):969-78.

PMID:
8212049
[PubMed - indexed for MEDLINE]

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