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Deciphering the Mechanisms of Developmental Disorders (DMDD): a new programme for phenotyping embryonic lethal mice.

Mohun T, Adams DJ, Baldock R, Bhattacharya S, Copp AJ, Hemberger M, Houart C, Hurles ME, Robertson E, Smith JC, Weaver T, Weninger W.

Dis Model Mech. 2013 May;6(3):562-6. doi: 10.1242/dmm.011957. Epub 2013 Mar 18.


Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening.

Adams D, Baldock R, Bhattacharya S, Copp AJ, Dickinson M, Greene ND, Henkelman M, Justice M, Mohun T, Murray SA, Pauws E, Raess M, Rossant J, Weaver T, West D.

Dis Model Mech. 2013 May;6(3):571-9. doi: 10.1242/dmm.011833. Epub 2013 Mar 18. Erratum in: Dis Model Mech. 2013 Jul;6(4):1049.


Phenotyping structural abnormalities in mouse embryos using high-resolution episcopic microscopy.

Weninger WJ, Geyer SH, Martineau A, Galli A, Adams DJ, Wilson R, Mohun TJ.

Dis Model Mech. 2014 Oct;7(10):1143-52. doi: 10.1242/dmm.016337.


Automated pipeline for anatomical phenotyping of mouse embryos using micro-CT.

Wong MD, Maezawa Y, Lerch JP, Henkelman RM.

Development. 2014 Jun;141(12):2533-41. doi: 10.1242/dev.107722. Epub 2014 May 21.


The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.

Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H.

Nucleic Acids Res. 2014 Jan;42(Database issue):D802-9. doi: 10.1093/nar/gkt977. Epub 2013 Nov 4.


Deficiency of zonula occludens-1 causes embryonic lethal phenotype associated with defected yolk sac angiogenesis and apoptosis of embryonic cells.

Katsuno T, Umeda K, Matsui T, Hata M, Tamura A, Itoh M, Takeuchi K, Fujimori T, Nabeshima Y, Noda T, Tsukita S, Tsukita S.

Mol Biol Cell. 2008 Jun;19(6):2465-75. doi: 10.1091/mbc.E07-12-1215. Epub 2008 Mar 19.


Mouse large-scale phenotyping initiatives: overview of the European Mouse Disease Clinic (EUMODIC) and of the Wellcome Trust Sanger Institute Mouse Genetics Project.

Ayadi A, Birling MC, Bottomley J, Bussell J, Fuchs H, Fray M, Gailus-Durner V, Greenaway S, Houghton R, Karp N, Leblanc S, Lengger C, Maier H, Mallon AM, Marschall S, Melvin D, Morgan H, Pavlovic G, Ryder E, Skarnes WC, Selloum M, Ramirez-Solis R, Sorg T, Teboul L, Vasseur L, Walling A, Weaver T, Wells S, White JK, Bradley A, Adams DJ, Steel KP, Hrabě de Angelis M, Brown SD, Herault Y.

Mamm Genome. 2012 Oct;23(9-10):600-10. doi: 10.1007/s00335-012-9418-y. Epub 2012 Sep 9. Review.


A novel 3D mouse embryo atlas based on micro-CT.

Wong MD, Dorr AE, Walls JR, Lerch JP, Henkelman RM.

Development. 2012 Sep;139(17):3248-56. doi: 10.1242/dev.082016.


Structural stabilization of tissue for embryo phenotyping using micro-CT with iodine staining.

Wong MD, Spring S, Henkelman RM.

PLoS One. 2013 Dec 30;8(12):e84321. doi: 10.1371/journal.pone.0084321. eCollection 2013.


The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse.

Nord AS, Chang PJ, Conklin BR, Cox AV, Harper CA, Hicks GG, Huang CC, Johns SJ, Kawamoto M, Liu S, Meng EC, Morris JH, Rossant J, Ruiz P, Skarnes WC, Soriano P, Stanford WL, Stryke D, von Melchner H, Wurst W, Yamamura K, Young SG, Babbitt PC, Ferrin TE.

Nucleic Acids Res. 2006 Jan 1;34(Database issue):D642-8.


Activating transcription factor 1 and CREB are important for cell survival during early mouse development.

Bleckmann SC, Blendy JA, Rudolph D, Monaghan AP, Schmid W, Schütz G.

Mol Cell Biol. 2002 Mar;22(6):1919-25.


Keratin 5-Cre-driven excision of nonmuscle myosin IIA in early embryo trophectoderm leads to placenta defects and embryonic lethality.

Crish J, Conti MA, Sakai T, Adelstein RS, Egelhoff TT.

Dev Biol. 2013 Oct 1;382(1):136-48. doi: 10.1016/j.ydbio.2013.07.017. Epub 2013 Jul 30.


Magnetic resonance virtual histology for embryos: 3D atlases for automated high-throughput phenotyping.

Cleary JO, Modat M, Norris FC, Price AN, Jayakody SA, Martinez-Barbera JP, Greene ND, Hawkes DJ, Ordidge RJ, Scambler PJ, Ourselin S, Lythgoe MF.

Neuroimage. 2011 Jan 15;54(2):769-78. doi: 10.1016/j.neuroimage.2010.07.039. Epub 2010 Jul 23.


Double bromodomain-containing gene Brd2 is essential for embryonic development in mouse.

Shang E, Wang X, Wen D, Greenberg DA, Wolgemuth DJ.

Dev Dyn. 2009 Apr;238(4):908-17. doi: 10.1002/dvdy.21911.


Inactivation of Palb2 gene leads to mesoderm differentiation defect and early embryonic lethality in mice.

Rantakari P, Nikkilä J, Jokela H, Ola R, Pylkäs K, Lagerbohm H, Sainio K, Poutanen M, Winqvist R.

Hum Mol Genet. 2010 Aug 1;19(15):3021-9. doi: 10.1093/hmg/ddq207. Epub 2010 May 18.


The gene trap resource: a treasure trove for hemopoiesis research.

Forrai A, Robb L.

Exp Hematol. 2005 Aug;33(8):845-56. Review.


Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2.

Hasumi Y, Baba M, Ajima R, Hasumi H, Valera VA, Klein ME, Haines DC, Merino MJ, Hong SB, Yamaguchi TP, Schmidt LS, Linehan WM.

Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18722-7. doi: 10.1073/pnas.0908853106. Epub 2009 Oct 22.


Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development.

Gangloff YG, Mueller M, Dann SG, Svoboda P, Sticker M, Spetz JF, Um SH, Brown EJ, Cereghini S, Thomas G, Kozma SC.

Mol Cell Biol. 2004 Nov;24(21):9508-16.


Global gene expression during the human organogenesis: from transcription profiles to function predictions.

Xue L, Yi H, Huang Z, Shi YB, Li WX.

Int J Biol Sci. 2011;7(7):1068-76. Epub 2011 Sep 7. Review.


Loss of mouse Ikbkap, a subunit of elongator, leads to transcriptional deficits and embryonic lethality that can be rescued by human IKBKAP.

Chen YT, Hims MM, Shetty RS, Mull J, Liu L, Leyne M, Slaugenhaupt SA.

Mol Cell Biol. 2009 Feb;29(3):736-44. doi: 10.1128/MCB.01313-08. Epub 2008 Nov 17.

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