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Results: 1 to 20 of 101

1.

All-trans-retinal sensitizes human RPE cells to alternative complement pathway-induced cell death.

Berchuck JE, Yang P, Toimil BA, Ma Z, Baciu P, Jaffe GJ.

Invest Ophthalmol Vis Sci. 2013 Apr 12;54(4):2669-77. doi: 10.1167/iovs.12-11020.

PMID:
23518773
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Retinal pigment epithelial cell death by the alternative complement cascade: role of membrane regulatory proteins, calcium, PKC, and oxidative stress.

Yang P, Baciu P, Kerrigan BC, Etheridge M, Sung E, Toimil BA, Berchuck JE, Jaffe GJ.

Invest Ophthalmol Vis Sci. 2014 May 6;55(5):3012-21. doi: 10.1167/iovs.13-13554.

PMID:
24677108
[PubMed - indexed for MEDLINE]
3.

Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age-related macular degeneration.

Ebrahimi KB, Fijalkowski N, Cano M, Handa JT.

J Pathol. 2013 Apr;229(5):729-42. doi: 10.1002/path.4128. Epub 2013 Jan 24.

PMID:
23097248
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Adenovirus-mediated delivery of CD46 attenuates the alternative complement pathway on RPE: implications for age-related macular degeneration.

Sweigard JH, Cashman SM, Kumar-Singh R.

Gene Ther. 2011 Jun;18(6):613-21. doi: 10.1038/gt.2011.6. Epub 2011 Feb 10.

PMID:
21307887
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Involvement of Endoplasmic Reticulum Stress in All-Trans-Retinal-Induced Retinal Pigment Epithelium Degeneration.

Li J, Cai X, Xia Q, Yao K, Chen J, Zhang Y, Naranmandura H, Liu X, Wu Y.

Toxicol Sci. 2014 Oct 20. pii: kfu223. [Epub ahead of print]

PMID:
25331497
[PubMed - as supplied by publisher]
6.

Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner.

Joseph K, Kulik L, Coughlin B, Kunchithapautham K, Bandyopadhyay M, Thiel S, Thielens NM, Holers VM, Rohrer B.

J Biol Chem. 2013 May 3;288(18):12753-65. doi: 10.1074/jbc.M112.421891. Epub 2013 Mar 14.

PMID:
23493397
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Oxidized low-density-lipoprotein-induced injury in retinal pigment epithelium alters expression of the membrane complement regulatory factors CD46 and CD59 through exosomal and apoptotic bleb release.

Ebrahimi KB, Fijalkowski N, Cano M, Handa JT.

Adv Exp Med Biol. 2014;801:259-65. doi: 10.1007/978-1-4614-3209-8_33.

PMID:
24664706
[PubMed - indexed for MEDLINE]
8.

Expression and modulation of RPE cell membrane complement regulatory proteins.

Yang P, Tyrrell J, Han I, Jaffe GJ.

Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3473-81. doi: 10.1167/iovs.08-3202. Epub 2009 Jan 24.

PMID:
19168900
[PubMed - indexed for MEDLINE]
Free Article
9.

Sub-lytic C5b-9 induces functional changes in retinal pigment epithelial cells consistent with age-related macular degeneration.

Lueck K, Wasmuth S, Williams J, Hughes TR, Morgan BP, Lommatzsch A, Greenwood J, Moss SE, Pauleikhoff D.

Eye (Lond). 2011 Aug;25(8):1074-82. doi: 10.1038/eye.2011.109. Epub 2011 May 20.

PMID:
21597483
[PubMed - indexed for MEDLINE]
Free PMC Article
10.

A targeted inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration.

Rohrer B, Long Q, Coughlin B, Renner B, Huang Y, Kunchithapautham K, Ferreira VP, Pangburn MK, Gilkeson GS, Thurman JM, Tomlinson S, Holers VM.

Adv Exp Med Biol. 2010;703:137-49. doi: 10.1007/978-1-4419-5635-4_10.

PMID:
20711712
[PubMed - indexed for MEDLINE]
11.

Resveratrol protects human retinal pigment epithelial cells from acrolein-induced damage.

Sheu SJ, Liu NC, Chen JL.

J Ocul Pharmacol Ther. 2010 Jun;26(3):231-6. doi: 10.1089/jop.2009.0137.

PMID:
20565308
[PubMed - indexed for MEDLINE]
12.

Antioxidant effect of trans-resveratrol in cultured human retinal pigment epithelial cells.

Pintea A, Rugină D, Pop R, Bunea A, Socaciu C, Diehl HA.

J Ocul Pharmacol Ther. 2011 Aug;27(4):315-21. doi: 10.1089/jop.2010.0144. Epub 2011 Jun 11.

PMID:
21663493
[PubMed - indexed for MEDLINE]
13.

Resveratrol stimulates mitochondrial bioenergetics to protect retinal pigment epithelial cells from oxidative damage.

Sheu SJ, Liu NC, Ou CC, Bee YS, Chen SC, Lin HC, Chan JY.

Invest Ophthalmol Vis Sci. 2013 Sep 27;54(9):6426-38. doi: 10.1167/iovs.13-12024.

PMID:
24008411
[PubMed - indexed for MEDLINE]
Free Article
14.

Amyloid-beta up-regulates complement factor B in retinal pigment epithelial cells through cytokines released from recruited macrophages/microglia: Another mechanism of complement activation in age-related macular degeneration.

Wang J, Ohno-Matsui K, Yoshida T, Shimada N, Ichinose S, Sato T, Mochizuki M, Morita I.

J Cell Physiol. 2009 Jul;220(1):119-28. doi: 10.1002/jcp.21742.

PMID:
19277984
[PubMed - indexed for MEDLINE]
15.

All-trans-retinal induces Bax activation via DNA damage to mediate retinal cell apoptosis.

Sawada O, Perusek L, Kohno H, Howell SJ, Maeda A, Matsuyama S, Maeda T.

Exp Eye Res. 2014 Jun;123:27-36. doi: 10.1016/j.exer.2014.04.003. Epub 2014 Apr 12.

PMID:
24726920
[PubMed - indexed for MEDLINE]
16.

Smoke exposure causes endoplasmic reticulum stress and lipid accumulation in retinal pigment epithelium through oxidative stress and complement activation.

Kunchithapautham K, Atkinson C, Rohrer B.

J Biol Chem. 2014 May 23;289(21):14534-46. doi: 10.1074/jbc.M114.564674. Epub 2014 Apr 7.

PMID:
24711457
[PubMed - indexed for MEDLINE]
17.

Prolonged SRC kinase activation, a mechanism to turn transient, sublytic complement activation into a sustained pathological condition in retinal pigment epithelium cells.

Rohrer B, Kunchithapautham K, Genewsky A, Strauß O.

Adv Exp Med Biol. 2014;801:221-7. doi: 10.1007/978-1-4614-3209-8_29.

PMID:
24664702
[PubMed - indexed for MEDLINE]
18.

Oxidative stress renders retinal pigment epithelial cells susceptible to complement-mediated injury.

Thurman JM, Renner B, Kunchithapautham K, Ferreira VP, Pangburn MK, Ablonczy Z, Tomlinson S, Holers VM, Rohrer B.

J Biol Chem. 2009 Jun 19;284(25):16939-47. doi: 10.1074/jbc.M808166200. Epub 2009 Apr 21.

PMID:
19386604
[PubMed - indexed for MEDLINE]
Free PMC Article
19.

Complement factor C3a alters proteasome function in human RPE cells and in an animal model of age-related RPE degeneration.

Ramos de Carvalho JE, Klaassen I, Vogels IM, Schipper-Krom S, van Noorden CJ, Reits E, Gorgels TG, Bergen AA, Schlingemann RO.

Invest Ophthalmol Vis Sci. 2013 Oct 3;54(10):6489-501. doi: 10.1167/iovs.13-12374.

PMID:
23982842
[PubMed - indexed for MEDLINE]
Free Article
20.

Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration.

Bertram KM, Baglole CJ, Phipps RP, Libby RT.

Am J Physiol Cell Physiol. 2009 Nov;297(5):C1200-10. doi: 10.1152/ajpcell.00126.2009. Epub 2009 Sep 16.

PMID:
19759330
[PubMed - indexed for MEDLINE]
Free PMC Article

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