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Items: 1 to 20 of 285

1.

Regulation of adipose branched-chain amino acid catabolism enzyme expression and cross-adipose amino acid flux in human obesity.

Lackey DE, Lynch CJ, Olson KC, Mostaedi R, Ali M, Smith WH, Karpe F, Humphreys S, Bedinger DH, Dunn TN, Thomas AP, Oort PJ, Kieffer DA, Amin R, Bettaieb A, Haj FG, Permana P, Anthony TG, Adams SH.

Am J Physiol Endocrinol Metab. 2013 Jun 1;304(11):E1175-87. doi: 10.1152/ajpendo.00630.2012. Epub 2013 Mar 19.

2.

Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolism.

She P, Van Horn C, Reid T, Hutson SM, Cooney RN, Lynch CJ.

Am J Physiol Endocrinol Metab. 2007 Dec;293(6):E1552-63. Epub 2007 Oct 9.

3.

Alterations of plasma metabolite profiles related to adipose tissue distribution and cardiometabolic risk.

Boulet MM, Chevrier G, Grenier-Larouche T, Pelletier M, Nadeau M, Scarpa J, Prehn C, Marette A, Adamski J, Tchernof A.

Am J Physiol Endocrinol Metab. 2015 Oct 15;309(8):E736-46. doi: 10.1152/ajpendo.00231.2015. Epub 2015 Aug 25.

PMID:
26306599
4.

Impaired adiponectin signaling contributes to disturbed catabolism of branched-chain amino acids in diabetic mice.

Lian K, Du C, Liu Y, Zhu D, Yan W, Zhang H, Hong Z, Liu P, Zhang L, Pei H, Zhang J, Gao C, Xin C, Cheng H, Xiong L, Tao L.

Diabetes. 2015 Jan;64(1):49-59. doi: 10.2337/db14-0312. Epub 2014 Jul 28.

5.

Regulation of hepatic branched-chain α-ketoacid dehydrogenase complex in rats fed a high-fat diet.

Kadota Y, Toyoda T, Kitaura Y, Adams SH, Shimomura Y.

Obes Res Clin Pract. 2013 Dec;7(6):e439-44.

PMID:
24459688
6.

Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism.

Shin AC, Fasshauer M, Filatova N, Grundell LA, Zielinski E, Zhou JY, Scherer T, Lindtner C, White PJ, Lapworth AL, Ilkayeva O, Knippschild U, Wolf AM, Scheja L, Grove KL, Smith RD, Qian WJ, Lynch CJ, Newgard CB, Buettner C.

Cell Metab. 2014 Nov 4;20(5):898-909. doi: 10.1016/j.cmet.2014.09.003. Epub 2014 Oct 9.

7.

Stimulation of mitochondrial oxidative capacity in white fat independent of UCP1: a key to lean phenotype.

Flachs P, Rossmeisl M, Kuda O, Kopecky J.

Biochim Biophys Acta. 2013 May;1831(5):986-1003. doi: 10.1016/j.bbalip.2013.02.003. Epub 2013 Feb 20.

8.

Protein phosphatase 2Cm is a critical regulator of branched-chain amino acid catabolism in mice and cultured cells.

Lu G, Sun H, She P, Youn JY, Warburton S, Ping P, Vondriska TM, Cai H, Lynch CJ, Wang Y.

J Clin Invest. 2009 Jun;119(6):1678-87. doi: 10.1172/JCI38151.

9.

Inflammation and ER stress regulate branched-chain amino acid uptake and metabolism in adipocytes.

Burrill JS, Long EK, Reilly B, Deng Y, Armitage IM, Scherer PE, Bernlohr DA.

Mol Endocrinol. 2015 Mar;29(3):411-20. doi: 10.1210/me.2014-1275. Epub 2015 Jan 30.

10.

Leucine and protein metabolism in obese Zucker rats.

She P, Olson KC, Kadota Y, Inukai A, Shimomura Y, Hoppel CL, Adams SH, Kawamata Y, Matsumoto H, Sakai R, Lang CH, Lynch CJ.

PLoS One. 2013;8(3):e59443. doi: 10.1371/journal.pone.0059443. Epub 2013 Mar 20.

11.

Multi-tissue, selective PPARγ modulation of insulin sensitivity and metabolic pathways in obese rats.

Hsiao G, Chapman J, Ofrecio JM, Wilkes J, Resnik JL, Thapar D, Subramaniam S, Sears DD.

Am J Physiol Endocrinol Metab. 2011 Jan;300(1):E164-74. doi: 10.1152/ajpendo.00219.2010. Epub 2010 Oct 19.

12.

Preventive effects of branched-chain amino acid supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL/KsJ-db/db obese mice.

Terakura D, Shimizu M, Iwasa J, Baba A, Kochi T, Ohno T, Kubota M, Shirakami Y, Shiraki M, Takai K, Tsurumi H, Tanaka T, Moriwaki H.

Carcinogenesis. 2012 Dec;33(12):2499-506. doi: 10.1093/carcin/bgs303. Epub 2012 Oct 1.

13.

A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance.

Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, Lien LF, Haqq AM, Shah SH, Arlotto M, Slentz CA, Rochon J, Gallup D, Ilkayeva O, Wenner BR, Yancy WS Jr, Eisenson H, Musante G, Surwit RS, Millington DS, Butler MD, Svetkey LP.

Cell Metab. 2009 Apr;9(4):311-26. doi: 10.1016/j.cmet.2009.02.002. Erratum in: Cell Metab. 2009 Jun;9(6):565-6.

14.

Inflammatory phenotyping identifies CD11d as a gene markedly induced in white adipose tissue in obese rodents and women.

Thomas AP, Dunn TN, Oort PJ, Grino M, Adams SH.

J Nutr. 2011 Jun;141(6):1172-80. doi: 10.3945/jn.110.127068. Epub 2011 Apr 20.

15.
16.

Defining the human adipose tissue proteome to reveal metabolic alterations in obesity.

Mardinoglu A, Kampf C, Asplund A, Fagerberg L, Hallström BM, Edlund K, Blüher M, Pontén F, Uhlen M, Nielsen J.

J Proteome Res. 2014 Nov 7;13(11):5106-19. doi: 10.1021/pr500586e. Epub 2014 Sep 25.

PMID:
25219818
17.

Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels.

Herman MA, She P, Peroni OD, Lynch CJ, Kahn BB.

J Biol Chem. 2010 Apr 9;285(15):11348-56. doi: 10.1074/jbc.M109.075184. Epub 2010 Jan 21.

18.

Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis.

Green CR, Wallace M, Divakaruni AS, Phillips SA, Murphy AN, Ciaraldi TP, Metallo CM.

Nat Chem Biol. 2016 Jan;12(1):15-21. doi: 10.1038/nchembio.1961. Epub 2015 Nov 16.

PMID:
26571352
19.

Regulation of branched-chain amino acid catabolism in rat models for spontaneous type 2 diabetes mellitus.

Kuzuya T, Katano Y, Nakano I, Hirooka Y, Itoh A, Ishigami M, Hayashi K, Honda T, Goto H, Fujita Y, Shikano R, Muramatsu Y, Bajotto G, Tamura T, Tamura N, Shimomura Y.

Biochem Biophys Res Commun. 2008 Aug 15;373(1):94-8. doi: 10.1016/j.bbrc.2008.05.167. Epub 2008 Jun 9.

PMID:
18541149
20.

Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice.

Iwasa J, Shimizu M, Shiraki M, Shirakami Y, Sakai H, Terakura Y, Takai K, Tsurumi H, Tanaka T, Moriwaki H.

Cancer Sci. 2010 Feb;101(2):460-7. doi: 10.1111/j.1349-7006.2009.01402.x. Epub 2009 Oct 15.

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