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Results: 1 to 20 of 122

1.

Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.

Kitson RR, Chang CH, Xiong R, Williams HE, Davis AL, Lewis W, Dehn DL, Siegel D, Roe SM, Prodromou C, Ross D, Moody CJ.

Nat Chem. 2013 Apr;5(4):307-14. doi: 10.1038/nchem.1596. Epub 2013 Mar 10.

PMID:
23511419
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

An improved route to 19-substituted geldanamycins as novel Hsp90 inhibitors--potential therapeutics in cancer and neurodegeneration.

Kitson RR, Moody CJ.

Chem Commun (Camb). 2013 Oct 4;49(76):8441-3. doi: 10.1039/c3cc43457e.

PMID:
23770604
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

Mechanistic studies on Hsp90 inhibition by ansamycin derivatives.

Onuoha SC, Mukund SR, Coulstock ET, Sengerovà B, Shaw J, McLaughlin SH, Jackson SE.

J Mol Biol. 2007 Sep 14;372(2):287-97. Epub 2007 Jun 29.

PMID:
17662999
[PubMed - indexed for MEDLINE]
4.

Synthesis of benzoquinone ansamycin-inspired macrocyclic lactams from shikimic acid.

Jeso V, Iqbal S, Hernandez P, Cameron MD, Park H, LoGrasso PV, Micalizio GC.

Angew Chem Int Ed Engl. 2013 Apr 26;52(18):4800-4. doi: 10.1002/anie.201301323. Epub 2013 Apr 2. No abstract available.

PMID:
23554224
[PubMed - indexed for MEDLINE]
5.

Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites.

Lee K, Ryu JS, Jin Y, Kim W, Kaur N, Chung SJ, Jeon YJ, Park JT, Bang JS, Lee HS, Kim TY, Lee JJ, Hong YS.

Org Biomol Chem. 2008 Jan 21;6(2):340-8. doi: 10.1039/b713407j. Epub 2007 Nov 30.

PMID:
18175003
[PubMed - indexed for MEDLINE]
6.

A mechanistic and structural analysis of the inhibition of the 90-kDa heat shock protein by the benzoquinone and hydroquinone ansamycins.

Reigan P, Siegel D, Guo W, Ross D.

Mol Pharmacol. 2011 May;79(5):823-32. doi: 10.1124/mol.110.070086. Epub 2011 Feb 1.

PMID:
21285336
[PubMed - indexed for MEDLINE]
Free PMC Article
7.

Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.

Ge J, Normant E, Porter JR, Ali JA, Dembski MS, Gao Y, Georges AT, Grenier L, Pak RH, Patterson J, Sydor JR, Tibbitts TT, Tong JK, Adams J, Palombella VJ.

J Med Chem. 2006 Jul 27;49(15):4606-15.

PMID:
16854066
[PubMed - indexed for MEDLINE]
8.

Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors.

Beebe K, Mollapour M, Scroggins B, Prodromou C, Xu W, Tokita M, Taldone T, Pullen L, Zierer BK, Lee MJ, Trepel J, Buchner J, Bolon D, Chiosis G, Neckers L.

Oncotarget. 2013 Jul;4(7):1065-74.

PMID:
23867252
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy.

Franke J, Eichner S, Zeilinger C, Kirschning A.

Nat Prod Rep. 2013 Oct 11;30(10):1299-323. doi: 10.1039/c3np70012g. Epub 2013 Aug 12. Review.

PMID:
23934201
[PubMed - indexed for MEDLINE]
10.

Discovery and development of heat shock protein 90 inhibitors as anticancer agents: a review of patented potent geldanamycin derivatives.

Kim T, Keum G, Pae AN.

Expert Opin Ther Pat. 2013 Aug;23(8):919-43. doi: 10.1517/13543776.2013.780597. Epub 2013 May 4. Review.

PMID:
23641970
[PubMed - indexed for MEDLINE]
11.

Design, synthesis, and structure--activity relationships for chimeric inhibitors of Hsp90.

Shen G, Wang M, Welch TR, Blagg BS.

J Org Chem. 2006 Sep 29;71(20):7618-31.

PMID:
16995666
[PubMed - indexed for MEDLINE]
12.

Synthetic ansamycins prepared by a ring-expanding Claisen rearrangement. Synthesis and biological evaluation of ring and conformational analogues of the Hsp90 molecular chaperone inhibitor geldanamycin.

McErlean CS, Proisy N, Davis CJ, Boland NA, Sharp SY, Boxall K, Slawin AM, Workman P, Moody CJ.

Org Biomol Chem. 2007 Feb 7;5(3):531-46. Epub 2007 Jan 4.

PMID:
17252137
[PubMed - indexed for MEDLINE]
13.

HSP90 inhibitors: multi-targeted antitumor effects and novel combinatorial therapeutic approaches in cancer therapy.

Hwang M, Moretti L, Lu B.

Curr Med Chem. 2009;16(24):3081-92. Review.

PMID:
19689285
[PubMed - indexed for MEDLINE]
14.

Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90.

Wrona IE, Gozman A, Taldone T, Chiosis G, Panek JS.

J Org Chem. 2010 May 7;75(9):2820-35. doi: 10.1021/jo1000109.

PMID:
20392070
[PubMed - indexed for MEDLINE]
Free PMC Article
15.

Convergent synthesis and discovery of a natural product-inspired paralog-selective Hsp90 inhibitor.

Jeso V, Cherry L, Macklin TK, Pan SC, LoGrasso PV, Micalizio GC.

Org Lett. 2011 Oct 7;13(19):5108-11. doi: 10.1021/ol2019828. Epub 2011 Aug 25.

PMID:
21866939
[PubMed - indexed for MEDLINE]
16.

Learning from nature: advances in geldanamycin- and radicicol-based inhibitors of Hsp90.

Kitson RR, Moody CJ.

J Org Chem. 2013 Jun 7;78(11):5117-41. doi: 10.1021/jo4002849. Epub 2013 Mar 26.

PMID:
23496136
[PubMed - indexed for MEDLINE]
17.

Design, synthesis, and biological evaluation of conformationally constrained cis-amide Hsp90 inhibitors.

Duerfeldt AS, Brandt GE, Blagg BS.

Org Lett. 2009 Jun 4;11(11):2353-6. doi: 10.1021/ol900783m.

PMID:
19435295
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Conformational significance of EH21A1-A4, phenolic derivatives of geldanamycin, for Hsp90 inhibitory activity.

Onodera H, Kaneko M, Takahashi Y, Uochi Y, Funahashi J, Nakashima T, Soga S, Suzuki M, Ikeda S, Yamashita Y, Rahayu ES, Kanda Y, Ichimura M.

Bioorg Med Chem Lett. 2008 Mar 1;18(5):1588-91. doi: 10.1016/j.bmcl.2008.01.072. Epub 2008 Jan 24.

PMID:
18243703
[PubMed - indexed for MEDLINE]
19.

Benzoquinone ansamycin heat shock protein 90 inhibitors modulate multiple functions required for tumor angiogenesis.

Sanderson S, Valenti M, Gowan S, Patterson L, Ahmad Z, Workman P, Eccles SA.

Mol Cancer Ther. 2006 Mar;5(3):522-32.

PMID:
16546966
[PubMed - indexed for MEDLINE]
Free Article
20.

Total synthesis of the Hsp90 inhibitor geldanamycin.

Qin HL, Panek JS.

Org Lett. 2008 Jun 19;10(12):2477-9. doi: 10.1021/ol800749w. Epub 2008 May 20.

PMID:
18489177
[PubMed - indexed for MEDLINE]
Free PMC Article

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