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Items: 1 to 20 of 128

1.

Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.

Kitson RR, Chang CH, Xiong R, Williams HE, Davis AL, Lewis W, Dehn DL, Siegel D, Roe SM, Prodromou C, Ross D, Moody CJ.

Nat Chem. 2013 Apr;5(4):307-14. doi: 10.1038/nchem.1596. Epub 2013 Mar 10.

2.
3.

Synthesis and biological evaluation of geldanamycin analogs against human cancer cells.

Li YP, Chen JJ, Shen JJ, Cui J, Wu LZ, Wang Z, Li ZR.

Cancer Chemother Pharmacol. 2015 Apr;75(4):773-82. doi: 10.1007/s00280-015-2696-9. Epub 2015 Feb 14.

PMID:
25681003
4.

Design, synthesis and biological evaluation of 17-arylmethylamine-17-demethoxygeldanamycin derivatives as potent Hsp90 inhibitors.

Li Z, Jia L, Wang J, Wu X, Hao H, Xu H, Wu Y, Shi G, Lu C, Shen Y.

Eur J Med Chem. 2014 Oct 6;85:359-70. doi: 10.1016/j.ejmech.2014.07.101. Epub 2014 Aug 1.

PMID:
25105924
5.

Mechanistic studies on Hsp90 inhibition by ansamycin derivatives.

Onuoha SC, Mukund SR, Coulstock ET, Sengerovà B, Shaw J, McLaughlin SH, Jackson SE.

J Mol Biol. 2007 Sep 14;372(2):287-97. Epub 2007 Jun 29.

PMID:
17662999
6.

Synthesis of benzoquinone ansamycin-inspired macrocyclic lactams from shikimic acid.

Jeso V, Iqbal S, Hernandez P, Cameron MD, Park H, LoGrasso PV, Micalizio GC.

Angew Chem Int Ed Engl. 2013 Apr 26;52(18):4800-4. doi: 10.1002/anie.201301323. Epub 2013 Apr 2. No abstract available.

PMID:
23554224
7.

Synthesis and anticancer activity of geldanamycin derivatives derived from biosynthetically generated metabolites.

Lee K, Ryu JS, Jin Y, Kim W, Kaur N, Chung SJ, Jeon YJ, Park JT, Bang JS, Lee HS, Kim TY, Lee JJ, Hong YS.

Org Biomol Chem. 2008 Jan 21;6(2):340-8. doi: 10.1039/b713407j. Epub 2007 Nov 30.

PMID:
18175003
8.

A mechanistic and structural analysis of the inhibition of the 90-kDa heat shock protein by the benzoquinone and hydroquinone ansamycins.

Reigan P, Siegel D, Guo W, Ross D.

Mol Pharmacol. 2011 May;79(5):823-32. doi: 10.1124/mol.110.070086. Epub 2011 Feb 1.

9.

Design, synthesis, and biological evaluation of hydroquinone derivatives of 17-amino-17-demethoxygeldanamycin as potent, water-soluble inhibitors of Hsp90.

Ge J, Normant E, Porter JR, Ali JA, Dembski MS, Gao Y, Georges AT, Grenier L, Pak RH, Patterson J, Sydor JR, Tibbitts TT, Tong JK, Adams J, Palombella VJ.

J Med Chem. 2006 Jul 27;49(15):4606-15.

PMID:
16854066
10.

Targeting heat-shock-protein 90 (Hsp90) by natural products: geldanamycin, a show case in cancer therapy.

Franke J, Eichner S, Zeilinger C, Kirschning A.

Nat Prod Rep. 2013 Oct 11;30(10):1299-323. doi: 10.1039/c3np70012g. Epub 2013 Aug 12. Review.

PMID:
23934201
11.

Discovery and development of heat shock protein 90 inhibitors as anticancer agents: a review of patented potent geldanamycin derivatives.

Kim T, Keum G, Pae AN.

Expert Opin Ther Pat. 2013 Aug;23(8):919-43. doi: 10.1517/13543776.2013.780597. Epub 2013 May 4. Review.

PMID:
23641970
12.

Design, synthesis, and structure--activity relationships for chimeric inhibitors of Hsp90.

Shen G, Wang M, Welch TR, Blagg BS.

J Org Chem. 2006 Sep 29;71(20):7618-31.

PMID:
16995666
13.

Synthetic ansamycins prepared by a ring-expanding Claisen rearrangement. Synthesis and biological evaluation of ring and conformational analogues of the Hsp90 molecular chaperone inhibitor geldanamycin.

McErlean CS, Proisy N, Davis CJ, Boland NA, Sharp SY, Boxall K, Slawin AM, Workman P, Moody CJ.

Org Biomol Chem. 2007 Feb 7;5(3):531-46. Epub 2007 Jan 4.

PMID:
17252137
14.
15.

Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90.

Wrona IE, Gozman A, Taldone T, Chiosis G, Panek JS.

J Org Chem. 2010 May 7;75(9):2820-35. doi: 10.1021/jo1000109.

16.

Convergent synthesis and discovery of a natural product-inspired paralog-selective Hsp90 inhibitor.

Jeso V, Cherry L, Macklin TK, Pan SC, LoGrasso PV, Micalizio GC.

Org Lett. 2011 Oct 7;13(19):5108-11. doi: 10.1021/ol2019828. Epub 2011 Aug 25.

PMID:
21866939
17.

Learning from nature: advances in geldanamycin- and radicicol-based inhibitors of Hsp90.

Kitson RR, Moody CJ.

J Org Chem. 2013 Jun 7;78(11):5117-41. doi: 10.1021/jo4002849. Epub 2013 Mar 26.

PMID:
23496136
18.

Posttranslational modification and conformational state of heat shock protein 90 differentially affect binding of chemically diverse small molecule inhibitors.

Beebe K, Mollapour M, Scroggins B, Prodromou C, Xu W, Tokita M, Taldone T, Pullen L, Zierer BK, Lee MJ, Trepel J, Buchner J, Bolon D, Chiosis G, Neckers L.

Oncotarget. 2013 Jul;4(7):1065-74.

19.

Design, synthesis, and biological evaluation of conformationally constrained cis-amide Hsp90 inhibitors.

Duerfeldt AS, Brandt GE, Blagg BS.

Org Lett. 2009 Jun 4;11(11):2353-6. doi: 10.1021/ol900783m.

20.

Conformational significance of EH21A1-A4, phenolic derivatives of geldanamycin, for Hsp90 inhibitory activity.

Onodera H, Kaneko M, Takahashi Y, Uochi Y, Funahashi J, Nakashima T, Soga S, Suzuki M, Ikeda S, Yamashita Y, Rahayu ES, Kanda Y, Ichimura M.

Bioorg Med Chem Lett. 2008 Mar 1;18(5):1588-91. doi: 10.1016/j.bmcl.2008.01.072. Epub 2008 Jan 24.

PMID:
18243703
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