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The role of ERK and JNK signaling in connective tissue growth factor induced extracellular matrix protein production and scar formation.

Hu X, Wang H, Liu J, Fang X, Tao K, Wang Y, Li N, Shi J, Wang Y, Ji P, Cai W, Bai X, Zhu X, Han J, Hu D.

Arch Dermatol Res. 2013 Jul;305(5):433-45. doi: 10.1007/s00403-013-1334-9. Epub 2013 Mar 15.


Activation of JNK signaling mediates connective tissue growth factor expression and scar formation in corneal wound healing.

Shi L, Chang Y, Yang Y, Zhang Y, Yu FS, Wu X.

PLoS One. 2012;7(2):e32128. doi: 10.1371/journal.pone.0032128. Epub 2012 Feb 21.


Connective tissue growth factor induces collagen I expression in human lung fibroblasts through the Rac1/MLK3/JNK/AP-1 pathway.

Lin CH, Yu MC, Tung WH, Chen TT, Yu CC, Weng CM, Tsai YJ, Bai KJ, Hong CY, Chien MH, Chen BC.

Biochim Biophys Acta. 2013 Dec;1833(12):2823-33. doi: 10.1016/j.bbamcr.2013.07.016. Epub 2013 Jul 29.


Effects of integrin ανβ3 on differentiation and collagen synthesis induced by connective tissue growth factor in human hypertrophic scar fibroblasts.

Hu X, Li N, Tao K, Fang X, Liu J, Wang Y, Wang H, Shi J, Wang Y, Ji P, Cai W, Bai X, Zhu X, Han J, Hu D.

Int J Mol Med. 2014 Nov;34(5):1323-34. doi: 10.3892/ijmm.2014.1912. Epub 2014 Aug 22.


Curcumin inhibits thrombin-stimulated connective tissue growth factor (CTGF/CCN2) production through c-Jun NH2-terminal kinase suppression in human gingival fibroblasts.

Chen YW, Yang WH, Wong MY, Chang HH, Yen-Ping Kuo M.

J Periodontol. 2012 Dec;83(12):1546-53. doi: 10.1902/jop.2012.110641. Epub 2012 Feb 10.


Mechanical force induces type I collagen expression in human periodontal ligament fibroblasts through activation of ERK/JNK and AP-1.

Kook SH, Hwang JM, Park JS, Kim EM, Heo JS, Jeon YM, Lee JC.

J Cell Biochem. 2009 Apr 15;106(6):1060-7. doi: 10.1002/jcb.22085.


Reversal of TGF-β1 stimulation of α-smooth muscle actin and extracellular matrix components by cyclic AMP in Dupuytren's-derived fibroblasts.

Satish L, Gallo PH, Baratz ME, Johnson S, Kathju S.

BMC Musculoskelet Disord. 2011 May 25;12:113. doi: 10.1186/1471-2474-12-113.


The anti-scar effects of basic fibroblast growth factor on the wound repair in vitro and in vivo.

Shi HX, Lin C, Lin BB, Wang ZG, Zhang HY, Wu FZ, Cheng Y, Xiang LJ, Guo DJ, Luo X, Zhang GY, Fu XB, Bellusci S, Li XK, Xiao J.

PLoS One. 2013;8(4):e59966. doi: 10.1371/journal.pone.0059966. Epub 2013 Apr 2.


C-Jun-NH2-terminal kinase mediates expression of connective tissue growth factor induced by transforming growth factor-beta1 in human lung fibroblasts.

Utsugi M, Dobashi K, Ishizuka T, Masubuchi K, Shimizu Y, Nakazawa T, Mori M.

Am J Respir Cell Mol Biol. 2003 Jun;28(6):754-61.


EGCG blocks TGFβ1-induced CCN2 by suppressing JNK and p38 in buccal fibroblasts.

Chang JZ, Yang WH, Deng YT, Chen HM, Kuo MY.

Clin Oral Investig. 2013 Mar;17(2):455-61. doi: 10.1007/s00784-012-0713-5. Epub 2012 Mar 15.


Regulation of TGF-beta 1-induced connective tissue growth factor expression in airway smooth muscle cells.

Xie S, Sukkar MB, Issa R, Oltmanns U, Nicholson AG, Chung KF.

Am J Physiol Lung Cell Mol Physiol. 2005 Jan;288(1):L68-76. Epub 2004 Sep 17.


Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.

Ponticos M, Holmes AM, Shi-wen X, Leoni P, Khan K, Rajkumar VS, Hoyles RK, Bou-Gharios G, Black CM, Denton CP, Abraham DJ, Leask A, Lindahl GE.

Arthritis Rheum. 2009 Jul;60(7):2142-55. doi: 10.1002/art.24620.


Pancreatic stellate cell activation by ethanol and acetaldehyde: is it mediated by the mitogen-activated protein kinase signaling pathway?

McCarroll JA, Phillips PA, Park S, Doherty E, Pirola RC, Wilson JS, Apte MV.

Pancreas. 2003 Aug;27(2):150-60.


Requirement for active glycogen synthase kinase-3β in TGF-β1 upregulation of connective tissue growth factor (CCN2/CTGF) levels in human gingival fibroblasts.

Bahammam M, Black SA Jr, Sume SS, Assaggaf MA, Faibish M, Trackman PC.

Am J Physiol Cell Physiol. 2013 Sep 15;305(6):C581-90. doi: 10.1152/ajpcell.00032.2013. Epub 2013 Jul 3.


Regulation of matrix contraction in chronic venous disease.

Pappas PJ, Lal BK, Ohara N, Saito S, Zapiach L, Durán WN.

Eur J Vasc Endovasc Surg. 2009 Oct;38(4):518-29. doi: 10.1016/j.ejvs.2009.05.012. Epub 2009 Jun 27.

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