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Results: 1 to 20 of 103

1.

Design and synthesis of a series of α-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility.

Ohashi M, Oyama T, Putranto EW, Waku T, Nobusada H, Kataoka K, Matsuno K, Yashiro M, Morikawa K, Huh NH, Miyachi H.

Bioorg Med Chem. 2013 Apr 15;21(8):2319-32. doi: 10.1016/j.bmc.2013.02.003. Epub 2013 Feb 14.

PMID:
23490155
[PubMed - indexed for MEDLINE]
2.

Design, synthesis, and structural analysis of phenylpropanoic acid-type PPARγ-selective agonists: discovery of reversed stereochemistry-activity relationship.

Ohashi M, Oyama T, Nakagome I, Satoh M, Nishio Y, Nobusada H, Hirono S, Morikawa K, Hashimoto Y, Miyachi H.

J Med Chem. 2011 Jan 13;54(1):331-41. doi: 10.1021/jm101233f. Epub 2010 Dec 3.

PMID:
21128600
[PubMed - indexed for MEDLINE]
3.

Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype.

Kuwabara N, Oyama T, Tomioka D, Ohashi M, Yanagisawa J, Shimizu T, Miyachi H.

J Med Chem. 2012 Jan 26;55(2):893-902. doi: 10.1021/jm2014293. Epub 2012 Jan 10.

PMID:
22185225
[PubMed - indexed for MEDLINE]
4.

Design, synthesis and in vitro evaluation of a series of α-substituted phenylpropanoic acid PPARγ agonists to further investigate the stereochemistry-activity relationship.

Ohashi M, Nakagome I, Kasuga J, Nobusada H, Matsuno K, Makishima M, Hirono S, Hashimoto Y, Miyachi H.

Bioorg Med Chem. 2012 Nov 1;20(21):6375-83. doi: 10.1016/j.bmc.2012.08.061. Epub 2012 Sep 11.

PMID:
23022278
[PubMed - indexed for MEDLINE]
5.

Structure-based design, synthesis, and nonalcoholic steatohepatitis (NASH)-preventive effect of phenylpropanoic acid peroxisome proliferator-activated receptor (PPAR) α-selective agonists.

Ban S, Kasuga J, Nakagome I, Nobusada H, Takayama F, Hirono S, Kawasaki H, Hashimoto Y, Miyachi H.

Bioorg Med Chem. 2011 May 15;19(10):3183-91. doi: 10.1016/j.bmc.2011.03.064. Epub 2011 Apr 8.

PMID:
21530275
[PubMed - indexed for MEDLINE]
6.

Design and synthesis of dual peroxisome proliferator-activated receptors gamma and delta agonists as novel euglycemic agents with a reduced weight gain profile.

Xu Y, Etgen GJ, Broderick CL, Canada E, Gonzalez I, Lamar J, Montrose-Rafizadeh C, Oldham BA, Osborne JJ, Xie C, Shi Q, Winneroski LL, York J, Yumibe N, Zink R, Mantlo N.

J Med Chem. 2006 Sep 21;49(19):5649-52.

PMID:
16970391
[PubMed - indexed for MEDLINE]
7.

Molecular dynamics study-guided identification of cyclic amine structures as novel hydrophobic tail components of hPPARγ agonists.

Tanaka Y, Gamo K, Oyama T, Ohashi M, Waki M, Matsuno K, Matsuura N, Tokiwa H, Miyachi H.

Bioorg Med Chem Lett. 2014 Jun 24. pii: S0960-894X(14)00651-9. doi: 10.1016/j.bmcl.2014.06.023. [Epub ahead of print]

PMID:
25017035
[PubMed - as supplied by publisher]
8.

Synthesis and evaluation of azaindole-alpha-alkyloxyphenylpropionic acid analogues as PPARalpha/gamma agonists.

Cai Z, Feng J, Guo Y, Li P, Shen Z, Chu F, Guo Z.

Bioorg Med Chem. 2006 Feb 1;14(3):866-74. Epub 2005 Oct 24.

PMID:
16249089
[PubMed - indexed for MEDLINE]
9.

Regulation of peroxisome proliferator-activated receptor gamma activity by losartan metabolites.

Schupp M, Lee LD, Frost N, Umbreen S, Schmidt B, Unger T, Kintscher U.

Hypertension. 2006 Mar;47(3):586-9. Epub 2005 Dec 19.

PMID:
16365190
[PubMed - indexed for MEDLINE]
Free Article
10.

Design, synthesis, and biological evaluation of novel constrained meta-substituted phenyl propanoic acids as peroxisome proliferator-activated receptor alpha and gamma dual agonists.

Suh YG, Kim NJ, Koo BW, Lee KO, Moon SH, Shin DH, Jung JW, Paek SM, Chang DJ, Li F, Kang HJ, Le TV, Chae YN, Shin CY, Kim MK, Lim JI, Ryu JS, Park HJ.

J Med Chem. 2008 Oct 23;51(20):6318-33. doi: 10.1021/jm8003416. Epub 2008 Oct 1.

PMID:
18826205
[PubMed - indexed for MEDLINE]
11.

Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists: effect of introduction of fluorine at the linker part.

Kasuga J, Oyama T, Hirakawa Y, Makishima M, Morikawa K, Hashimoto Y, Miyachi H.

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4525-8. doi: 10.1016/j.bmcl.2008.07.046. Epub 2008 Jul 15.

PMID:
18662876
[PubMed - indexed for MEDLINE]
12.

Improvement of water-solubility of biarylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) δ-selective partial agonists by disruption of molecular planarity/symmetry.

Kasuga J, Ishikawa M, Yonehara M, Makishima M, Hashimoto Y, Miyachi H.

Bioorg Med Chem. 2010 Oct 15;18(20):7164-73. doi: 10.1016/j.bmc.2010.08.041. Epub 2010 Aug 24.

PMID:
20843696
[PubMed - indexed for MEDLINE]
13.

Design, synthesis and evaluation of substituted phenylpropanoic acid derivatives as peroxisome proliferator-activated receptor (PPAR) activators: novel human PPARalpha-selective activators.

Miyachi H, Nomura M, Tanase T, Takahashi Y, Ide T, Tsunoda M, Murakami K, Awano K.

Bioorg Med Chem Lett. 2002 Jan 7;12(1):77-80.

PMID:
11738577
[PubMed - indexed for MEDLINE]
14.

Design, synthesis, and evaluation of a novel series of alpha-substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor (PPAR) alpha/delta dual agonists for the treatment of metabolic syndrome.

Kasuga J, Yamasaki D, Araya Y, Nakagawa A, Makishima M, Doi T, Hashimoto Y, Miyachi H.

Bioorg Med Chem. 2006 Dec 15;14(24):8405-14. Epub 2006 Sep 25.

PMID:
16996742
[PubMed - indexed for MEDLINE]
15.

Design and synthesis of substituted phenylpropanoic acid derivatives as human peroxisome proliferator-activated receptor alpha/delta dual agonists.

Kasuga J, Makishima M, Hashimoto Y, Miyachi H.

Bioorg Med Chem Lett. 2006 Feb;16(3):554-8. Epub 2005 Nov 3.

PMID:
16275077
[PubMed - indexed for MEDLINE]
16.

Effects of modifications of the linker in a series of phenylpropanoic acid derivatives: Synthesis, evaluation as PPARalpha/gamma dual agonists, and X-ray crystallographic studies.

Casimiro-Garcia A, Bigge CF, Davis JA, Padalino T, Pulaski J, Ohren JF, McConnell P, Kane CD, Royer LJ, Stevens KA, Auerbach BJ, Collard WT, McGregor C, Fakhoury SA, Schaum RP, Zhou H.

Bioorg Med Chem. 2008 May 1;16(9):4883-907. doi: 10.1016/j.bmc.2008.03.043. Epub 2008 Mar 20.

PMID:
18394907
[PubMed - indexed for MEDLINE]
17.

[Design and synthesis of subtype- and species-selective peroxisome proliferator-activated receptor (PPAR) alpha ligands].

Miyachi H.

Yakugaku Zasshi. 2004 Nov;124(11):803-13. Review. Japanese.

PMID:
15516807
[PubMed - indexed for MEDLINE]
Free Article
18.

Design and synthesis of alpha-aryloxy-alpha-methylhydrocinnamic acids: a novel class of dual peroxisome proliferator-activated receptor alpha/gamma agonists.

Xu Y, Rito CJ, Etgen GJ, Ardecky RJ, Bean JS, Bensch WR, Bosley JR, Broderick CL, Brooks DA, Dominianni SJ, Hahn PJ, Liu S, Mais DE, Montrose-Rafizadeh C, Ogilvie KM, Oldham BA, Peters M, Rungta DK, Shuker AJ, Stephenson GA, Tripp AE, Wilson SB, Winneroski LL, Zink R, Kauffman RF, McCarthy JR.

J Med Chem. 2004 May 6;47(10):2422-5.

PMID:
15115385
[PubMed - indexed for MEDLINE]
19.

Sulfonylthiadiazoles with an unusual binding mode as partial dual peroxisome proliferator-activated receptor (PPAR) γ/δ agonists with high potency and in vivo efficacy.

Keil S, Matter H, Schönafinger K, Glien M, Mathieu M, Marquette JP, Michot N, Haag-Diergarten S, Urmann M, Wendler W.

ChemMedChem. 2011 Apr 4;6(4):633-53. doi: 10.1002/cmdc.201100047. Epub 2011 Mar 11.

PMID:
21400663
[PubMed - indexed for MEDLINE]
20.

Design and synthesis of oxime ethers of alpha-acyl-beta-phenylpropanoic acids as PPAR dual agonists.

Oon Han H, Kim SH, Kim KH, Hur GC, Joo Yim H, Chung HK, Ho Woo S, Dong Koo K, Lee CS, Sung Koh J, Kim GT.

Bioorg Med Chem Lett. 2007 Feb 15;17(4):937-41. Epub 2006 Nov 18.

PMID:
17157019
[PubMed - indexed for MEDLINE]

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