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Results: 1 to 20 of 120

1.

Structural effect of phenyl ring compared to thiadiazole based adamantyl-sulfonamides on carbonic anhydrase inhibition.

Biswas S, Carta F, Scozzafava A, McKenna R, Supuran CT.

Bioorg Med Chem. 2013 Apr 15;21(8):2314-8. doi: 10.1016/j.bmc.2013.02.022. Epub 2013 Feb 21.

PMID:
23490152
[PubMed - indexed for MEDLINE]
2.

Carbonic anhydrase inhibitors. Inhibition of the cytosolic and tumor-associated carbonic anhydrase isozymes I, II, and IX with a series of 1,3,4-thiadiazole- and 1,2,4-triazole-thiols.

Almajan GL, Innocenti A, Puccetti L, Manole G, Barbuceanu S, Saramet I, Scozzafava A, Supuran CT.

Bioorg Med Chem Lett. 2005 May 2;15(9):2347-52.

PMID:
15837323
[PubMed - indexed for MEDLINE]
3.

Design, synthesis, and docking studies of new 1,3,4-thiadiazole-2-thione derivatives with carbonic anhydrase inhibitory activity.

Abdel-Hamid MK, Abdel-Hafez AA, El-Koussi NA, Mahfouz NM, Innocenti A, Supuran CT.

Bioorg Med Chem. 2007 Nov 15;15(22):6975-84. Epub 2007 Aug 22.

PMID:
17822907
[PubMed - indexed for MEDLINE]
4.

Carbonic anhydrase inhibitors. Interaction of 2-N,N-dimethylamino-1,3,4-thiadiazole-5-methanesulfonamide with 12 mammalian isoforms: kinetic and X-ray crystallographic studies.

Temperini C, Cecchi A, Boyle NA, Scozzafava A, Cabeza JE, Wentworth P Jr, Blackburn GM, Supuran CT.

Bioorg Med Chem Lett. 2008 Feb 1;18(3):999-1005. Epub 2007 Dec 15.

PMID:
18162396
[PubMed - indexed for MEDLINE]
5.

Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies.

Carta F, Garaj V, Maresca A, Wagner J, Avvaru BS, Robbins AH, Scozzafava A, McKenna R, Supuran CT.

Bioorg Med Chem. 2011 May 15;19(10):3105-19. doi: 10.1016/j.bmc.2011.04.005. Epub 2011 Apr 6.

PMID:
21515057
[PubMed - indexed for MEDLINE]
6.

5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: solution and X-ray crystallographic studies.

Leitans J, Sprudza A, Tanc M, Vozny I, Zalubovskis R, Tars K, Supuran CT.

Bioorg Med Chem. 2013 Sep 1;21(17):5130-8. doi: 10.1016/j.bmc.2013.06.041. Epub 2013 Jun 27.

PMID:
23859774
[PubMed - indexed for MEDLINE]
7.

Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides.

Ozensoy O, Puccetti L, Fasolis G, Arslan O, Scozzafava A, Supuran CT.

Bioorg Med Chem Lett. 2005 Nov 1;15(21):4862-6.

PMID:
16168653
[PubMed - indexed for MEDLINE]
8.

Conformational variability of different sulfonamide inhibitors with thienyl-acetamido moieties attributes to differential binding in the active site of cytosolic human carbonic anhydrase isoforms.

Biswas S, Aggarwal M, Güzel Ö, Scozzafava A, McKenna R, Supuran CT.

Bioorg Med Chem. 2011 Jun 15;19(12):3732-8. doi: 10.1016/j.bmc.2011.05.006. Epub 2011 May 10.

PMID:
21620713
[PubMed - indexed for MEDLINE]
9.

Structural study of the location of the phenyl tail of benzene sulfonamides and the effect on human carbonic anhydrase inhibition.

Güzel-Akdemir O, Biswas S, Lastra K, McKenna R, Supuran CT.

Bioorg Med Chem. 2013 Nov 1;21(21):6674-80. doi: 10.1016/j.bmc.2013.08.011. Epub 2013 Aug 12.

PMID:
24012377
[PubMed - indexed for MEDLINE]
10.

Coumarinyl-substituted sulfonamides strongly inhibit several human carbonic anhydrase isoforms: solution and crystallographic investigations.

Wagner J, Avvaru BS, Robbins AH, Scozzafava A, Supuran CT, McKenna R.

Bioorg Med Chem. 2010 Jul 15;18(14):4873-8. doi: 10.1016/j.bmc.2010.06.028. Epub 2010 Jun 15.

PMID:
20598552
[PubMed - indexed for MEDLINE]
Free PMC Article
11.

Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes.

Puccetti L, Fasolis G, Vullo D, Chohan ZH, Scozzafava A, Supuran CT.

Bioorg Med Chem Lett. 2005 Jun 15;15(12):3096-101.

PMID:
15908204
[PubMed - indexed for MEDLINE]
12.

Carbonic anhydrase inhibitors. The X-ray crystal structure of human isoform II in adduct with an adamantyl analogue of acetazolamide resides in a less utilized binding pocket than most hydrophobic inhibitors.

Avvaru BS, Wagner JM, Maresca A, Scozzafava A, Robbins AH, Supuran CT, McKenna R.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4376-81. doi: 10.1016/j.bmcl.2010.06.082. Epub 2010 Jun 17.

PMID:
20605094
[PubMed - indexed for MEDLINE]
13.

Carbonic anhydrase inhibitors: synthesis and inhibition of the human carbonic anhydrase isoforms I, II, VII, IX and XII with benzene sulfonamides incorporating 4,5,6,7-tetrabromophthalimide moiety.

Sethi KK, Vullo D, Verma SM, Tanç M, Carta F, Supuran CT.

Bioorg Med Chem. 2013 Oct 1;21(19):5973-82. doi: 10.1016/j.bmc.2013.07.044. Epub 2013 Aug 2.

PMID:
23965175
[PubMed - indexed for MEDLINE]
14.

Carbonic anhydrase inhibitors. Synthesis of topically effective intraocular pressure lowering agents derived from 5-(omega-aminoalkylcarboxamido)-1,3,4-thiadiazole-2-sulfonamide.

Barboiu M, Supuran CT, Menabuoni L, Scozzafava A, Mincione F, Briganti F, Mincione G.

J Enzyme Inhib. 2000;15(1):23-46.

PMID:
10850953
[PubMed - indexed for MEDLINE]
15.

Identification of 3,4-Dihydroisoquinoline-2(1H)-sulfonamides as potent carbonic anhydrase inhibitors: synthesis, biological evaluation, and enzyme--ligand X-ray studies.

Gitto R, Agnello S, Ferro S, De Luca L, Vullo D, Brynda J, Mader P, Supuran CT, Chimirri A.

J Med Chem. 2010 Mar 25;53(6):2401-8. doi: 10.1021/jm9014026.

PMID:
20170095
[PubMed - indexed for MEDLINE]
16.

Amide derivatives with pyrazole carboxylic acids of 5-amino-1,3,4-thiadiazole 2-sulfonamide as new carbonic anhydrase inhibitors: synthesis and investigation of inhibitory effects.

Bülbül M, Kasimoğullari R, Küfrevioğlu OI.

J Enzyme Inhib Med Chem. 2008 Dec;23(6):895-900. doi: 10.1080/14756360701626173 .

PMID:
18618324
[PubMed - indexed for MEDLINE]
17.

Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of 5-amino-1,3,4-thiadiazole-2-sulfonamide and 5-(4-amino-3-chloro-5-fluorophenylsulfonamido)-1,3,4-thiadiazole-2-sulfonamide to human isoform II.

Menchise V, De Simone G, Di Fiore A, Scozzafava A, Supuran CT.

Bioorg Med Chem Lett. 2006 Dec 15;16(24):6204-8. Epub 2006 Sep 26.

PMID:
17000110
[PubMed - indexed for MEDLINE]
18.

Development of potent carbonic anhydrase inhibitors incorporating both sulfonamide and sulfamide groups.

D'Ambrosio K, Smaine FZ, Carta F, De Simone G, Winum JY, Supuran CT.

J Med Chem. 2012 Aug 9;55(15):6776-83. doi: 10.1021/jm300818k. Epub 2012 Jul 20.

PMID:
22775345
[PubMed - indexed for MEDLINE]
19.

Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB.

Güzel O, Innocenti A, Scozzafava A, Salman A, Supuran CT.

Bioorg Med Chem. 2009 Jul 15;17(14):4894-9. doi: 10.1016/j.bmc.2009.06.006. Epub 2009 Jun 9.

PMID:
19539481
[PubMed - indexed for MEDLINE]
20.

Carbonic anhydrase inhibitors: novel sulfonamides incorporating 1,3,5-triazine moieties as inhibitors of the cytosolic and tumour-associated carbonic anhydrase isozymes I, II and IX.

Garaj V, Puccetti L, Fasolis G, Winum JY, Montero JL, Scozzafava A, Vullo D, Innocenti A, Supuran CT.

Bioorg Med Chem Lett. 2005 Jun 15;15(12):3102-8.

PMID:
15905091
[PubMed - indexed for MEDLINE]

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