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Items: 1 to 20 of 179

1.

Estrogen receptor β sustains epithelial differentiation by regulating prolyl hydroxylase 2 transcription.

Mak P, Chang C, Pursell B, Mercurio AM.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4708-13. doi: 10.1073/pnas.1221654110. Epub 2013 Mar 4.

2.

Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-alpha-prolyl-4-hydroxylases.

Marxsen JH, Stengel P, Doege K, Heikkinen P, Jokilehto T, Wagner T, Jelkmann W, Jaakkola P, Metzen E.

Biochem J. 2004 Aug 1;381(Pt 3):761-7.

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Endothelin-1 inhibits prolyl hydroxylase domain 2 to activate hypoxia-inducible factor-1alpha in melanoma cells.

Spinella F, Rosanò L, Del Duca M, Di Castro V, Nicotra MR, Natali PG, Bagnato A.

PLoS One. 2010 Jun 21;5(6):e11241. doi: 10.1371/journal.pone.0011241.

5.

Oxygen sensing by the prolyl-4-hydroxylase PHD2 within the nuclear compartment and the influence of compartmentalisation on HIF-1 signalling.

Pientka FK, Hu J, Schindler SG, Brix B, Thiel A, Jöhren O, Fandrey J, Berchner-Pfannschmidt U, Depping R.

J Cell Sci. 2012 Nov 1;125(Pt 21):5168-76. doi: 10.1242/jcs.109041. Epub 2012 Sep 3.

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Expression of prolyl hydroxylases (PHDs) is selectively controlled by HIF-1 and HIF-2 proteins in nucleus pulposus cells of the intervertebral disc: distinct roles of PHD2 and PHD3 proteins in controlling HIF-1α activity in hypoxia.

Fujita N, Markova D, Anderson DG, Chiba K, Toyama Y, Shapiro IM, Risbud MV.

J Biol Chem. 2012 May 11;287(20):16975-86. doi: 10.1074/jbc.M111.334466. Epub 2012 Mar 26.

8.

Regulation of HIF prolyl hydroxylases by hypoxia-inducible factors.

Aprelikova O, Chandramouli GV, Wood M, Vasselli JR, Riss J, Maranchie JK, Linehan WM, Barrett JC.

J Cell Biochem. 2004 Jun 1;92(3):491-501. Erratum in: J Cell Biochem. 2004 Oct 15;93(3):639.

PMID:
15156561
9.

Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression.

McMahon S, Charbonneau M, Grandmont S, Richard DE, Dubois CM.

J Biol Chem. 2006 Aug 25;281(34):24171-81. Epub 2006 Jun 30.

10.

Src activates HIF-1α not through direct phosphorylation of HIF-1α specific prolyl-4 hydroxylase 2 but through activation of the NADPH oxidase/Rac pathway.

Lee HY, Lee T, Lee N, Yang EG, Lee C, Lee J, Moon EY, Ha J, Park H.

Carcinogenesis. 2011 May;32(5):703-12. doi: 10.1093/carcin/bgr034. Epub 2011 Feb 18.

11.

Leu-574 of human HIF-1alpha is a molecular determinant of prolyl hydroxylation.

Kageyama Y, Koshiji M, To KK, Tian YM, Ratcliffe PJ, Huang LE.

FASEB J. 2004 Jun;18(9):1028-30. Epub 2004 Apr 14.

12.

Hypoxia-inducible factor prolyl-hydroxylase-2 mediates transforming growth factor beta 1-induced epithelial-mesenchymal transition in renal tubular cells.

Han WQ, Zhu Q, Hu J, Li PL, Zhang F, Li N.

Biochim Biophys Acta. 2013 Jun;1833(6):1454-62. doi: 10.1016/j.bbamcr.2013.02.029. Epub 2013 Mar 1.

13.

Sequence determinants in hypoxia-inducible factor-1alpha for hydroxylation by the prolyl hydroxylases PHD1, PHD2, and PHD3.

Huang J, Zhao Q, Mooney SM, Lee FS.

J Biol Chem. 2002 Oct 18;277(42):39792-800. Epub 2002 Aug 13.

14.

Overexpression and nuclear translocation of hypoxia-inducible factor prolyl hydroxylase PHD2 in head and neck squamous cell carcinoma is associated with tumor aggressiveness.

Jokilehto T, Rantanen K, Luukkaa M, Heikkinen P, Grenman R, Minn H, Kronqvist P, Jaakkola PM.

Clin Cancer Res. 2006 Feb 15;12(4):1080-7.

15.

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.

Hewitson KS, Schofield CJ, Ratcliffe PJ.

Methods Enzymol. 2007;435:25-42.

PMID:
17998047
16.

A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove.

Percy MJ, Furlow PW, Beer PA, Lappin TR, McMullin MF, Lee FS.

Blood. 2007 Sep 15;110(6):2193-6. Epub 2007 Jun 19.

17.

Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha.

Chan DA, Sutphin PD, Yen SE, Giaccia AJ.

Mol Cell Biol. 2005 Aug;25(15):6415-26.

18.

Nitric oxide donor, (+/-)-S-nitroso-N-acetylpenicillamine, stabilizes transactive hypoxia-inducible factor-1alpha by inhibiting von Hippel-Lindau recruitment and asparagine hydroxylation.

Park YK, Ahn DR, Oh M, Lee T, Yang EG, Son M, Park H.

Mol Pharmacol. 2008 Jul;74(1):236-45. doi: 10.1124/mol.108.045278. Epub 2008 Apr 21.

19.

An activator of PHD2, KRH102140, decreases angiogenesis via inhibition of HIF-1α.

Nepal M, Gong YD, Park YR, Soh Y.

Cell Biochem Funct. 2011 Mar;29(2):126-34. doi: 10.1002/cbf.1732. Epub 2011 Feb 1.

PMID:
21287578
20.

Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling.

Wiley M, Sweeney KR, Chan DA, Brown KM, McMurtrey C, Howard EW, Giaccia AJ, Blader IJ.

J Biol Chem. 2010 Aug 27;285(35):26852-60. doi: 10.1074/jbc.M110.147041. Epub 2010 Jun 25.

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