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Results: 1 to 20 of 137

1.

HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila.

Xiong Y, Zhao K, Wu J, Xu Z, Jin S, Zhang YQ.

Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):4604-9. doi: 10.1073/pnas.1207586110. Epub 2013 Mar 4.

PMID:
23487739
[PubMed - indexed for MEDLINE]
Free PMC Article
2.

Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy.

Brunden KR, Zhang B, Carroll J, Yao Y, Potuzak JS, Hogan AM, Iba M, James MJ, Xie SX, Ballatore C, Smith AB 3rd, Lee VM, Trojanowski JQ.

J Neurosci. 2010 Oct 13;30(41):13861-6. doi: 10.1523/JNEUROSCI.3059-10.2010.

PMID:
20943926
[PubMed - indexed for MEDLINE]
Free PMC Article
3.

The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice.

Zhang B, Carroll J, Trojanowski JQ, Yao Y, Iba M, Potuzak JS, Hogan AM, Xie SX, Ballatore C, Smith AB 3rd, Lee VM, Brunden KR.

J Neurosci. 2012 Mar 14;32(11):3601-11. doi: 10.1523/JNEUROSCI.4922-11.2012.

PMID:
22423084
[PubMed - indexed for MEDLINE]
Free PMC Article
4.

Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies.

Brunden KR, Ballatore C, Lee VM, Smith AB 3rd, Trojanowski JQ.

Biochem Soc Trans. 2012 Aug;40(4):661-6. doi: 10.1042/BST20120010. Review.

PMID:
22817712
[PubMed - indexed for MEDLINE]
Free PMC Article
5.

Histone deacetylase 6 interacts with the microtubule-associated protein tau.

Ding H, Dolan PJ, Johnson GV.

J Neurochem. 2008 Sep;106(5):2119-30. doi: 10.1111/j.1471-4159.2008.05564.x. Epub 2008 Jul 12.

PMID:
18636984
[PubMed - indexed for MEDLINE]
Free PMC Article
6.

Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027.

Barten DM, Fanara P, Andorfer C, Hoque N, Wong PY, Husted KH, Cadelina GW, Decarr LB, Yang L, Liu V, Fessler C, Protassio J, Riff T, Turner H, Janus CG, Sankaranarayanan S, Polson C, Meredith JE, Gray G, Hanna A, Olson RE, Kim SH, Vite GD, Lee FY, Albright CF.

J Neurosci. 2012 May 23;32(21):7137-45. doi: 10.1523/JNEUROSCI.0188-12.2012.

PMID:
22623658
[PubMed - indexed for MEDLINE]
Free Article
7.

Tau--an inhibitor of deacetylase HDAC6 function.

Perez M, Santa-Maria I, Gomez de Barreda E, Zhu X, Cuadros R, Cabrero JR, Sanchez-Madrid F, Dawson HN, Vitek MP, Perry G, Smith MA, Avila J.

J Neurochem. 2009 Jun;109(6):1756-66. doi: 10.1111/j.1471-4159.2009.06102.x. Epub 2009 May 7.

PMID:
19457097
[PubMed - indexed for MEDLINE]
8.

The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies.

Brunden KR, Yao Y, Potuzak JS, Ferrer NI, Ballatore C, James MJ, Hogan AM, Trojanowski JQ, Smith AB 3rd, Lee VM.

Pharmacol Res. 2011 Apr;63(4):341-51. doi: 10.1016/j.phrs.2010.12.002. Epub 2010 Dec 14.

PMID:
21163349
[PubMed - indexed for MEDLINE]
Free PMC Article
9.

Rescue of neurons from undergoing hallmark tau-induced Alzheimer's disease cell pathologies by the antimitotic drug paclitaxel.

Shemesh OA, Spira ME.

Neurobiol Dis. 2011 Jul;43(1):163-75. doi: 10.1016/j.nbd.2011.03.008. Epub 2011 Mar 13.

PMID:
21406229
[PubMed - indexed for MEDLINE]
10.

Microtubule destruction induces tau liberation and its subsequent phosphorylation.

Miyasaka T, Sato S, Tatebayashi Y, Takashima A.

FEBS Lett. 2010 Jul 16;584(14):3227-32. doi: 10.1016/j.febslet.2010.06.014. Epub 2010 Jun 17.

PMID:
20561519
[PubMed - indexed for MEDLINE]
Free Article
11.

A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics.

Rosenmann H, Grigoriadis N, Eldar-Levy H, Avital A, Rozenstein L, Touloumi O, Behar L, Ben-Hur T, Avraham Y, Berry E, Segal M, Ginzburg I, Abramsky O.

Exp Neurol. 2008 Jul;212(1):71-84. doi: 10.1016/j.expneurol.2008.03.007. Epub 2008 Mar 21.

PMID:
18490011
[PubMed - indexed for MEDLINE]
12.

HDAC6 inhibition results in tau acetylation and modulates tau phosphorylation and degradation in oligodendrocytes.

Noack M, Leyk J, Richter-Landsberg C.

Glia. 2014 Apr;62(4):535-47. doi: 10.1002/glia.22624. Epub 2014 Jan 24.

PMID:
24464872
[PubMed - indexed for MEDLINE]
13.

Taxol-stabilized microtubules promote the formation of filaments from unmodified full-length Tau in vitro.

Duan AR, Goodson HV.

Mol Biol Cell. 2012 Dec;23(24):4796-806. doi: 10.1091/mbc.E12-05-0374. Epub 2012 Oct 19.

PMID:
23087208
[PubMed - indexed for MEDLINE]
Free PMC Article
14.

Neuropathogenic role of adenylate kinase-1 in Aβ-mediated tau phosphorylation via AMPK and GSK3β.

Park H, Kam TI, Kim Y, Choi H, Gwon Y, Kim C, Koh JY, Jung YK.

Hum Mol Genet. 2012 Jun 15;21(12):2725-37. doi: 10.1093/hmg/dds100. Epub 2012 Mar 13.

PMID:
22419736
[PubMed - indexed for MEDLINE]
Free Article
15.

Drosophila models of human tauopathies indicate that Tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein.

Feuillette S, Miguel L, Frébourg T, Campion D, Lecourtois M.

J Neurochem. 2010 May;113(4):895-903. doi: 10.1111/j.1471-4159.2010.06663.x. Epub 2010 Feb 27.

PMID:
20193038
[PubMed - indexed for MEDLINE]
16.

Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease.

Shahpasand K, Uemura I, Saito T, Asano T, Hata K, Shibata K, Toyoshima Y, Hasegawa M, Hisanaga S.

J Neurosci. 2012 Feb 15;32(7):2430-41. doi: 10.1523/JNEUROSCI.5927-11.2012.

PMID:
22396417
[PubMed - indexed for MEDLINE]
Free Article
17.

Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo.

Planel E, Krishnamurthy P, Miyasaka T, Liu L, Herman M, Kumar A, Bretteville A, Figueroa HY, Yu WH, Whittington RA, Davies P, Takashima A, Nixon RA, Duff KE.

J Neurosci. 2008 Nov 26;28(48):12798-807. doi: 10.1523/JNEUROSCI.4101-08.2008.

PMID:
19036972
[PubMed - indexed for MEDLINE]
Free PMC Article
18.

Microtubule stabilization by peloruside A and paclitaxel rescues degenerating neurons from okadaic acid-induced tau phosphorylation.

Das V, Miller JH.

Eur J Neurosci. 2012 Jun;35(11):1705-17. doi: 10.1111/j.1460-9568.2012.08084.x. Epub 2012 May 17.

PMID:
22594877
[PubMed - indexed for MEDLINE]
19.

Neurofibrillary tangles and tau phosphorylation.

Brion JP, Anderton BH, Authelet M, Dayanandan R, Leroy K, Lovestone S, Octave JN, Pradier L, Touchet N, Tremp G.

Biochem Soc Symp. 2001;(67):81-8.

PMID:
11447842
[PubMed - indexed for MEDLINE]
20.

Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies.

Ballatore C, Brunden KR, Huryn DM, Trojanowski JQ, Lee VM, Smith AB 3rd.

J Med Chem. 2012 Nov 8;55(21):8979-96. doi: 10.1021/jm301079z. Epub 2012 Sep 28. Review.

PMID:
23020671
[PubMed - indexed for MEDLINE]
Free PMC Article

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