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Items: 1 to 20 of 110

1.

Endogenous lipid activated G protein-coupled receptors: emerging structural features from crystallography and molecular dynamics simulations.

Hurst DP, Schmeisser M, Reggio PH.

Chem Phys Lipids. 2013 Apr;169:46-56. doi: 10.1016/j.chemphyslip.2013.01.009. Epub 2013 Feb 26. Review.

2.

Lipid bilayer molecular dynamics study of lipid-derived agonists of the putative cannabinoid receptor, GPR55.

Kotsikorou E, Lynch DL, Abood ME, Reggio PH.

Chem Phys Lipids. 2011 Feb;164(2):131-43. doi: 10.1016/j.chemphyslip.2010.12.003. Epub 2010 Dec 24.

3.
4.

A computational study on cannabinoid receptors and potent bioactive cannabinoid ligands: homology modeling, docking, de novo drug design and molecular dynamics analysis.

Durdagi S, Papadopoulos MG, Zoumpoulakis PG, Koukoulitsa C, Mavromoustakos T.

Mol Divers. 2010 May;14(2):257-76. doi: 10.1007/s11030-009-9166-4. Epub 2009 Jun 18.

PMID:
19536636
5.

Structural basis for ligand binding and specificity in adrenergic receptors: implications for GPCR-targeted drug discovery.

Huber T, Menon S, Sakmar TP.

Biochemistry. 2008 Oct 21;47(42):11013-23. doi: 10.1021/bi800891r. Epub 2008 Sep 27.

PMID:
18821775
6.

X-ray structure breakthroughs in the GPCR transmembrane region.

Topiol S, Sabio M.

Biochem Pharmacol. 2009 Jul 1;78(1):11-20. doi: 10.1016/j.bcp.2009.02.012. Epub 2009 Feb 27. Review.

PMID:
19447219
7.

A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor.

Hurst DP, Grossfield A, Lynch DL, Feller S, Romo TD, Gawrisch K, Pitman MC, Reggio PH.

J Biol Chem. 2010 Jun 4;285(23):17954-64. doi: 10.1074/jbc.M109.041590. Epub 2010 Mar 10.

8.

Chemogenomic analysis of G-protein coupled receptors and their ligands deciphers locks and keys governing diverse aspects of signalling.

Wichard JD, Ter Laak A, Krause G, Heinrich N, Kühne R, Kleinau G.

PLoS One. 2011 Feb 4;6(2):e16811. doi: 10.1371/journal.pone.0016811.

9.

Structural features of the apelin receptor N-terminal tail and first transmembrane segment implicated in ligand binding and receptor trafficking.

Langelaan DN, Reddy T, Banks AW, Dellaire G, Dupré DJ, Rainey JK.

Biochim Biophys Acta. 2013 Jun;1828(6):1471-83. doi: 10.1016/j.bbamem.2013.02.005. Epub 2013 Feb 22.

10.

Rhodopsin: insights from recent structural studies.

Sakmar TP, Menon ST, Marin EP, Awad ES.

Annu Rev Biophys Biomol Struct. 2002;31:443-84. Epub 2001 Oct 25. Review.

PMID:
11988478
11.

Definition of the G protein-coupled receptor transmembrane bundle binding pocket and calculation of receptor similarities for drug design.

Gloriam DE, Foord SM, Blaney FE, Garland SL.

J Med Chem. 2009 Jul 23;52(14):4429-42. doi: 10.1021/jm900319e.

PMID:
19537715
12.

Comparative sequence and structural analyses of G-protein-coupled receptor crystal structures and implications for molecular models.

Worth CL, Kleinau G, Krause G.

PLoS One. 2009 Sep 16;4(9):e7011. doi: 10.1371/journal.pone.0007011.

13.

Modeling of ligand binding to G protein coupled receptors: cannabinoid CB1, CB2 and adrenergic β 2 AR.

Latek D, Kolinski M, Ghoshdastider U, Debinski A, Bombolewski R, Plazinska A, Jozwiak K, Filipek S.

J Mol Model. 2011 Sep;17(9):2353-66. doi: 10.1007/s00894-011-0986-7. Epub 2011 Mar 2.

PMID:
21365223
14.
15.

Action of molecular switches in GPCRs--theoretical and experimental studies.

Trzaskowski B, Latek D, Yuan S, Ghoshdastider U, Debinski A, Filipek S.

Curr Med Chem. 2012;19(8):1090-109. Review.

16.

Charged extracellular residues, conserved throughout a G-protein-coupled receptor family, are required for ligand binding, receptor activation, and cell-surface expression.

Hawtin SR, Simms J, Conner M, Lawson Z, Parslow RA, Trim J, Sheppard A, Wheatley M.

J Biol Chem. 2006 Dec 15;281(50):38478-88. Epub 2006 Sep 21.

17.

Chemokine receptors and other G protein-coupled receptors.

Lodowski DT, Palczewski K.

Curr Opin HIV AIDS. 2009 Mar;4(2):88-95. doi: 10.1097/COH.0b013e3283223d8d. Review.

18.

Homology modeling and molecular dynamics simulations of the mu opioid receptor in a membrane-aqueous system.

Zhang Y, Sham YY, Rajamani R, Gao J, Portoghese PS.

Chembiochem. 2005 May;6(5):853-9.

PMID:
15776407
19.

Observation of "ionic lock" formation in molecular dynamics simulations of wild-type beta 1 and beta 2 adrenergic receptors.

Vanni S, Neri M, Tavernelli I, Rothlisberger U.

Biochemistry. 2009 Jun 9;48(22):4789-97. doi: 10.1021/bi900299f.

PMID:
19378975
20.

Exploring a model of a chemokine receptor/ligand complex in an explicit membrane environment by molecular dynamics simulation: the human CCR1 receptor.

Shahlaei M, Madadkar-Sobhani A, Fassihi A, Saghaie L.

J Chem Inf Model. 2011 Oct 24;51(10):2717-30. doi: 10.1021/ci200261f. Epub 2011 Sep 28.

PMID:
21910472
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