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Items: 1 to 20 of 109

1.

Ribotoxic stress through p38 mitogen-activated protein kinase activates in vitro the human pyrin inflammasome.

Yu JW, Farias A, Hwang I, Fernandes-Alnemri T, Alnemri ES.

J Biol Chem. 2013 Apr 19;288(16):11378-83. doi: 10.1074/jbc.M112.448795. Epub 2013 Mar 11.

2.

Pyrin activates the ASC pyroptosome in response to engagement by autoinflammatory PSTPIP1 mutants.

Yu JW, Fernandes-Alnemri T, Datta P, Wu J, Juliana C, Solorzano L, McCormick M, Zhang Z, Alnemri ES.

Mol Cell. 2007 Oct 26;28(2):214-27.

3.

Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome.

Xu H, Yang J, Gao W, Li L, Li P, Zhang L, Gong YN, Peng X, Xi JJ, Chen S, Wang F, Shao F.

Nature. 2014 Sep 11;513(7517):237-41. doi: 10.1038/nature13449. Epub 2014 Jun 11.

PMID:
24919149
4.

Identification of multifaceted binding modes for pyrin and ASC pyrin domains gives insights into pyrin inflammasome assembly.

Vajjhala PR, Kaiser S, Smith SJ, Ong QR, Soh SL, Stacey KJ, Hill JM.

J Biol Chem. 2014 Aug 22;289(34):23504-19. doi: 10.1074/jbc.M114.553305. Epub 2014 Jul 8.

5.

Defect of suppression of inflammasome-independent interleukin-8 secretion from SW982 synovial sarcoma cells by familial Mediterranean fever-derived pyrin mutations.

Sugiyama R, Agematsu K, Migita K, Nakayama J, Mokuda S, Ogura F, Haraikawa K, Okumura C, Suehiro S, Morikawa S, Ito Y, Masumoto J.

Mol Biol Rep. 2014 Jan;41(1):545-53. doi: 10.1007/s11033-013-2890-y. Epub 2013 Dec 7.

PMID:
24318677
6.

The SPRY domain of Pyrin, mutated in familial Mediterranean fever patients, interacts with inflammasome components and inhibits proIL-1beta processing.

Papin S, Cuenin S, Agostini L, Martinon F, Werner S, Beer HD, Grütter C, Grütter M, Tschopp J.

Cell Death Differ. 2007 Aug;14(8):1457-66. Epub 2007 Apr 13.

7.

The effect of colchicine on pyrin and pyrin interacting proteins.

Taskiran EZ, Cetinkaya A, Balci-Peynircioglu B, Akkaya YZ, Yilmaz E.

J Cell Biochem. 2012 Nov;113(11):3536-46. doi: 10.1002/jcb.24231.

PMID:
22730186
8.

The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production.

Chae JJ, Wood G, Masters SL, Richard K, Park G, Smith BJ, Kastner DL.

Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9982-7. Epub 2006 Jun 19.

9.

The familial Mediterranean fever protein, pyrin, is cleaved by caspase-1 and activates NF-kappaB through its N-terminal fragment.

Chae JJ, Wood G, Richard K, Jaffe H, Colburn NT, Masters SL, Gumucio DL, Shoham NG, Kastner DL.

Blood. 2008 Sep 1;112(5):1794-803. doi: 10.1182/blood-2008-01-134932. Epub 2008 Jun 24.

11.

Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization.

Yu JW, Wu J, Zhang Z, Datta P, Ibrahimi I, Taniguchi S, Sagara J, Fernandes-Alnemri T, Alnemri ES.

Cell Death Differ. 2006 Feb;13(2):236-49.

12.

Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin-1-Syk and p62/SQSTM1.

Lee HM, Yuk JM, Kim KH, Jang J, Kang G, Park JB, Son JW, Jo EK.

Immunol Cell Biol. 2012 Jul;90(6):601-10. doi: 10.1038/icb.2011.72. Epub 2011 Aug 30.

13.

Pyrin Modulates the Intracellular Distribution of PSTPIP1.

Waite AL, Schaner P, Richards N, Balci-Peynircioglu B, Masters SL, Brydges SD, Fox M, Hong A, Yilmaz E, Kastner DL, Reinherz EL, Gumucio DL.

PLoS One. 2009 Jul 7;4(7):e6147. doi: 10.1371/journal.pone.0006147.

14.

Activation of the pyrin inflammasome by intracellular Burkholderia cenocepacia.

Gavrilin MA, Abdelaziz DH, Mostafa M, Abdulrahman BA, Grandhi J, Akhter A, Abu Khweek A, Aubert DF, Valvano MA, Wewers MD, Amer AO.

J Immunol. 2012 Apr 1;188(7):3469-77. doi: 10.4049/jimmunol.1102272. Epub 2012 Feb 24.

15.

Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages.

Budai MM, Varga A, Milesz S, Tőzsér J, Benkő S.

Mol Immunol. 2013 Dec;56(4):471-9. doi: 10.1016/j.molimm.2013.05.005. Epub 2013 Aug 1.

PMID:
23911403
16.

Multiple binding sites on the pyrin domain of ASC protein allow self-association and interaction with NLRP3 protein.

Vajjhala PR, Mirams RE, Hill JM.

J Biol Chem. 2012 Dec 7;287(50):41732-43. doi: 10.1074/jbc.M112.381228. Epub 2012 Oct 12.

17.

Activation of the Nlrp1b inflammasome by reduction of cytosolic ATP.

Liao KC, Mogridge J.

Infect Immun. 2013 Feb;81(2):570-9. doi: 10.1128/IAI.01003-12. Epub 2012 Dec 10.

18.

A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages.

Zheng Y, Lilo S, Brodsky IE, Zhang Y, Medzhitov R, Marcu KB, Bliska JB.

PLoS Pathog. 2011 Apr;7(4):e1002026. doi: 10.1371/journal.ppat.1002026. Epub 2011 Apr 21.

19.

Purification and analysis of the interactions of caspase-1 and ASC for assembly of the inflammasome.

Narayanan KB, Park HH.

Appl Biochem Biotechnol. 2015 Mar;175(6):2883-94. doi: 10.1007/s12010-014-1471-4. Epub 2015 Jan 8.

PMID:
25567507
20.

The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome.

Taxman DJ, Holley-Guthrie EA, Huang MT, Moore CB, Bergstralh DT, Allen IC, Lei Y, Gris D, Ting JP.

J Biol Chem. 2011 Jun 3;286(22):19605-16. doi: 10.1074/jbc.M111.221077. Epub 2011 Apr 12.

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